CV Lattes
Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba (FOP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor of Microbiology and Immunology at Piracicaba Dental School, Unicamp and Associate Professor of Periodontology at the Faculté de Medecine Dentaire, Université Laval, Quebec, Canada. He has degree in dentistry from the Unicamp (1987), specializing in Endodontics by the FOP-Unicamp (1989), master's degree in Biology Pathology Bucco-Dental Unicamp (1994) and PhD in Microbiology by the Federal University of Rio de Janeiro (1998). He has done a post doctoral training in the Forsyth Institute, Boston, USA (2002-2005). He has experience in the field of dentistry, with emphasis on Oral Microbiology and Immunology, acting mainly on the following themes: endodontic and periodontal infection, caries, biofilm, bacterial diversity, antimicrobial activity and immune response. (Source: Lattes Curriculum)
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It is estimated that only 50% of oral bacteria can be cultivated and it is possible that pathogenic microorganisms are also found among non cultivated ones. The main model for studying microbial diversity is amplifying the 16S rDNA gene, cloning of the amplicons in Escherichia coli, and sequencing the cloned inserts. Besides, the technique of denaturating gradient gel electrophoresis (DGG…
Human antimicrobial peptides have a broad spectrum of bactericidal activity against to Gram-positive and Gram-negative bacteria, fungi and enveloped viruses. They appear to be engaged in the regulation of both innate and adaptive immune functions in oral cavity. In the present proposal, taking advantage of specific polyclonal antibodies developed against these antimicrobial peptides, we w…
Streptococcus mutans is the main etiologic agent of the dental caries. The synthesis of lactic acid, the acid tolerance and the formation of dental biofilm by glucosiltransferases enzymes and glucan binding proteins, are virulence factors of this microorganism involved in the process of development of the dental caries. The search for new antimicrobial natural agents capable to inhibit su…
Human antimicrobial peptides as LL37 presents a broad spectrum of bactericidal activity against to Gram-positive and Gram-negative bacteria, fungi and enveloped viruses, thus, represent an important defense mechanism against the pathogenic microorganisms invasion. They appear to be engaged in the regulation of both innate and adaptive immune functions in oral cavity. Our aims are to evalu…
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