Graduate in Pharmacy and Biochemistry at Faculty of Pharmaceutical Sciences, University of São Paulo (2001), Visit fellow at the University of California, UCSD (2005), PhD at Pharmacology by the Institute of Biomedical Sciences, University of São Paulo - ICB/USP (2002-2006) and postdoctoral fellow at Department of Immunology, ICB/USP (2006-2010). Researcher at Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden (2010-2011). He is currently position as an Assistant Professor at Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo (FBC/FCF/USP). He has experience in Immunology and Cellular Biology, focus on the following subjects: insulin, cytokines, inflammation, signaling pathways and cellular immunology. (Source: Lattes Curriculum)
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Aging is a natural and multifactorial process characterized by a gradual loss of physiological integrity, impaired normal and essential functions to survival of the body, and leading to the development of age-related diseases. In this context, autophagy, a process of intracellular content degradation, is regulated naturally by the mammalian target nutrient receptor of rapamycin (mTOR) or …
Obesity is a chronic metabolic disease that may be associated with physiological disorders, such as diabetes mellitus (DM) and hypertension (HTN). Some studies have shown common pathways linking obesity and diabetes to insulin resistance and the renin-angiotensin system (RAS), a leading regulator of blood pressure. Angiotensinogen (Agt) is the main precursor of RAS. Activation of Agt in a…
Obesity is a complex disease that increases mortality and associated comorbities such as diabetes and cardiovascular diseases. One of the critical pathways involved in obesity is the Renin Angiotensin System (RAS) which is classically known to regulate blood pressure and fluid balance is also expressed in adipose tissue. RAS contributes to inflammation in obesity and diabetes and is often…
Asthma is a complex disease that simultaneously involves the participation of several cells, cytokines and inflammatory mediators on which the initial phase is completely different from the late stage. In previous work, we used an experimental omdel developen in mice pre-immunized with ovalbumin (OVA) and found that insulin interferes with the production/release of cytokines, cell migrati…
(Only some records are available in English at this moment)
Autophagy is a catabolic process of stress response or a natural pathway that is directly related to cellular homeostasis, through the degradation of cellular components by the lysosomal pathway. Paracoccidioidomycosis (PCM) is a systemic mycosis and represents an important Public Health problem due to its high disabling potential, in addition to causing premature deaths, especially in im…
Asthma and Diabetes are complex diseases, with high incidence rates all over the world and show certain antagonism. Previous studies reported the process of autophagy is correlated with lung remodelling, pancreatic ² cell proliferation and differentiation of T and B cells. The present study intends to understand what role autophagy plays in asthma and diabetes. The asthma model proposed i…
Hyperglycemia is the main characteristic of diabetes mellitus (DM) and is associated with high mortality in affected individuals. In previous studies, we evaluated phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB, or Akt) and mitogen-activated protein kinase (MAPK) proteins in bone marrow-derived macrophages (BMDM) after lipopolysaccharide (LPS) stimulation, treated or not with…
Aging is a natural and multifactorial process obtained by the gradual loss of physiological integrity. In this context, autophagy, a process of intracellular content degradation, naturally regulated by the rapamycin target nutrient sensing receptor (mTOR) or chemically by the drug rapamycin (RAPA), has a direct relationship with cellular homeostasis and maintenance of the senescent phenot…
Autophagy is an essential metabolic pathway for cellular homeostasis process, which Perform a constitutive and active function in controlling the biosynthesis of proteins and organelles, furthermore, it is a genetically regulated and conserved cellular process. This pathway is naturally regulated by the nutrient sensing receptor denominated the mechanistic target of Rapamycin (mTOR) or ch…
Obesity is a chronic metabolic disease that may be associated with various medical disorders including, for example, Diabetes Mellitus (DM) and Hypertension (HTN). Some studies have shown common pathways linking obesity and diabetes to insulin resistance and the Renin-Angiotensin System (RAS),regulator of blood pressure. Angiotensinogen (Agt) is the main precursor of RAS, with angiotensin…
(Only some records are available in English at this moment)
Aging is a natural and multifactorial process characterized by a gradual loss of physiological integrity, impairing normal and essential functions to survival of the body, and leading to the development of age-related diseases, increasing the vulnerability to death of the organism. In this context, autophagy, a process of degradation of intracellular content, naturally regulated by the nu…
Obesity is a chronic metabolic disease that may be associated with physiological disorders, such as diabetes mellitus (DM) and hypertension. Studies have shown common pathways linking obesity to insulin resistance and the renin-angiotensin system (RAS). Angiotensinogen (Agt) is the main precursor of RAS. Activation of Agt is often linked to dysfunctions in cellular processes, such as auto…
Introduction: In clinical condition, partial hepatectomy (PH) under ischemia-reperfusion (I/R) is commonly accomplished to control bleeding during hepatic resection. It is well known that I/R significantly reduces liver regeneration after hepatectomy. Diabetes mellitus (DM) is particularly associated with poor prognosis of I/R injury. Fibroblast growth factor 21 (FGF21) has beneficial me…
| 1 / 1 | Ongoing research grants |
| 13 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 13 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 33 / 25 | All research grants and scholarships |
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CV Lattes
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