CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Pharmacy and Biochemistry at Faculty of Pharmaceutical Sciences, University of São Paulo (2001), Visit fellow at the University of California, UCSD (2005), PhD at Pharmacology by the Institute of Biomedical Sciences, University of São Paulo - ICB/USP (2002-2006) and postdoctoral fellow at Department of Immunology, ICB/USP (2006-2010). Researcher at Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden (2010-2011). He is currently position as an Assistant Professor at Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo (FBC/FCF/USP). He has experience in Immunology and Cellular Biology, focus on the following subjects: insulin, cytokines, inflammation, signaling pathways and cellular immunology. (Source: Lattes Curriculum)
Obesity is a chronic metabolic disease that may be associated with physiological disorders, such as diabetes mellitus (DM) and hypertension (HTN). Some studies have shown common pathways linking obesity and diabetes to insulin resistance and the renin-angiotensin system (RAS), a leading regulator of blood pressure. Angiotensinogen (Agt) is the main precursor of RAS. Activation of Agt in a…
Obesity is a complex disease that increases mortality and associated comorbities such as diabetes and cardiovascular diseases. One of the critical pathways involved in obesity is the Renin Angiotensin System (RAS) which is classically known to regulate blood pressure and fluid balance is also expressed in adipose tissue. RAS contributes to inflammation in obesity and diabetes and is often…
Asthma is a complex disease that simultaneously involves the participation of several cells, cytokines and inflammatory mediators on which the initial phase is completely different from the late stage. In previous work, we used an experimental omdel developen in mice pre-immunized with ovalbumin (OVA) and found that insulin interferes with the production/release of cytokines, cell migrati…
Diabetic subjects are more susceptible to infections, which is at least partially due to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine release by macrophages stimulated with lipopolysaccharides (LPS) in diabetic C57BL/6 mice. Using bone marrow-derived macrophages (BMDM) from diabetic mice, we showed that LPS induced an increase in TNF-± and IL-6 re…
(Only some records are available in English at this moment)
Obesity is a chronic metabolic disease that may be associated with various medical disorders including, for example, Diabetes Mellitus (DM) and Hypertension (HTN). Some studies have shown common pathways linking obesity and diabetes to insulin resistance and the Renin-Angiotensin System (RAS),regulator of blood pressure. Angiotensinogen (Agt) is the main precursor of RAS, with angiotensin…
Introduction: In clinical situations, partial hepatectomy (PH) under ischaemia-reperfusion (I/R) is usually performed to control bleeding during parenchymal dissection. Diabetes is particularly associated with poor prognosis of ischemia reperfusion (I/R) injury. It is well known that I/R significantly reduces liver regeneration after hepatectomy. Fibroblast growth factor 21 (FGF21) is mem…
Vitamin D is a steroid hormone synthesized in the skin, which is involved in many physiological processes (homeostasis of phosphorus and calcium, modulation of the immune system) and pathological (autoimmune diseases such as type 1 diabetes mellitus). This disease is characterized by destruction of beta cells through the action of pancreatic B lymphocytes, macrophages, T cells, CD4 + and …
Vitamin D is a steroid hormone that acts in several mechanisms physiological (participating in the regulation of calcium homeostasis and immune system) and pathological (type 1 diabetes and tumors). Activation of vitamin D occurs through the effect of UVB rays on the skin with subsequent hydroxylations in liver and kidney. After activation, the interaction occurs with the Vitamin D Recept…
(Only some records are available in English at this moment)
Obesity is a chronic metabolic disease that may be associated with physiological disorders, such as diabetes mellitus (DM) and hypertension. Studies have shown common pathways linking obesity to insulin resistance and the renin-angiotensin system (RAS). Angiotensinogen (Agt) is the main precursor of RAS. Activation of Agt is often linked to dysfunctions in cellular processes, such as auto…
Introduction: In clinical condition, partial hepatectomy (PH) under ischemia-reperfusion (I/R) is commonly accomplished to control bleeding during hepatic resection. It is well known that I/R significantly reduces liver regeneration after hepatectomy. Diabetes mellitus (DM) is particularly associated with poor prognosis of I/R injury. Fibroblast growth factor 21 (FGF21) has beneficial me…
| 2 / 1 | Ongoing research grants |
| 11 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 26 / 18 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 47 |
| Cit./Article | 2.6 |
| Data from Web of Science | |
RAJASEKARAN, SUBU SURENDRAN; ILLIES, CHRISTOPHER; SHEARS, STEPHEN B.; WANG, HUANCHEN; AYALA, THAIS S.; MARTINS, JOILSON O.; DARE, ELISABETTA; BERGGREN, PER-OLOF; BARKER, CHRISTOPHER J.. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic beta-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. CELLULAR SIGNALLING, v. 42, p. 127-133, JAN 2018. Web of Science Citations: 1. (10/02272-0, 14/05214-1)
NOLASCO, EDUARDO L.; ZANONI, FERNANDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; FREITAS, LUIZA A.; SILVA, MARIANA C. F.; MARTINS, JOILSON O.. Insulin Modulates Liver Function in a Type I Diabetes Rat Model. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 36, n. 4, p. 1467-1479, 2015. Web of Science Citations: 7. (10/02272-0, 14/05214-1)
SUNAHARA, KAREN K. S.; NUNES, FERNANDA P. B.; BAPTISTA, MARISA A. P.; STRELL, CARINA; SANNOMIYA, PAULINA; WESTERBERG, LISA S.; MARTINS, JOILSON O.. Insulin Influences Autophagy Response Distinctively in Macrophages of Different Compartments. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 34, n. 6, p. 2017-2026, 2014. Web of Science Citations: 1. (10/02272-0)
CASAGRANDE, FELIPE BECCARIA; FERREIRA, SABRINA DE SOUZA; BARBOSA NUNES, FERNANDA PEIXOTO; DAL'MAS ROMERA, LAVINIA MARIA; DOS SANTOS, SUELEN SILVANA; GALVAO TESSARO, FERNANDO HENRIQUE; KNOX DE SOUZA, PAULA REGINA; ALMEIDA, SANDRO ROGERIO; MARTINS, JOILSON OLIVEIRA. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. JOURNAL OF DIABETES RESEARCH, 2018. Web of Science Citations: 0. (17/11540-7, 12/06652-7, 14/05214-1, 12/06617-7, 10/02272-0)
CASAGRANDE, FELIPE BECCARIA; FERREIRA, SABRINA DE SOUZA; ALHO DE SOUSA, EMANUELLA SARMENTO; TORRES GUIMARAES, JOAO PEDRO; DAL'MAS ROMERA, LAVINIA MARIA; GALVAO TESSARO, FERNANDO HENRIQUE; DE ALMEIDA, SANDRO ROGERIO; DE PAULA RODRIGUES, STEPHEN FERNANDES; MARTINS, JOILSON O.. Insulin Modulates Inflammatory Cytokine Release in Acute Stages and Augments Expression of Adhesion Molecules and Leukocytes in Lungs on Chronic Stages of Paracoccidioidomycosis. FRONTIERS IN IMMUNOLOGY, v. 11, NOV 18 2020. Web of Science Citations: 0. (17/11540-7, 14/05214-1)
FERREIRA, SABRINA S.; OLIVEIRA, MARIA A.; TSUJITA, MARISTELA; NUNES, FERNANDA P. B.; CASAGRANDE, FELIPE B.; GOMES, ELIANE; RUSSO, MOMTCHILO; TAVARES DE LIMA, WOTHAN; MARTINS, JOILSON O.. Insulin Modulates the Immune Cell Phenotype in Pulmonary Allergic Inflammation and Increases Pulmonary Resistance in Diabetic Mice. FRONTIERS IN IMMUNOLOGY, v. 11, FEB 11 2020. Web of Science Citations: 0. (14/05214-1, 17/11540-7)
BARROS, MICHELE S.; LARA, PRISCILA G.; FONSECA, MONIQUE T.; MORETTI, EDUARDO H.; FILGUEIRAS, LUCIANO R.; MARTINS, JOILSON O.; CAPURRO, MARGARETH L.; STEINER, ALEXANDRE A.; SA-NUNES, ANDERSON. Aedes aegypti saliva impairs M1-associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages. PARASITES & VECTORS, v. 12, MAY 16 2019. Web of Science Citations: 1. (16/04921-1, 15/22934-0, 13/12467-0, 17/11540-7)
MENDES-BRAZ, MARIANA; MARTINS, JOILSON O.. Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation. Mediators of Inflammation, 2018. Web of Science Citations: 4. (16/24992-0, 17/11540-7)
GALVAO TESSARO, FERNANDO HENRIQUE; AYALA, THAIS SOPRANI; BELLA, LEONARDO MENDES; MARTINS, JOILSON OLIVEIRA. Macrophages from a type 1 diabetes mouse model present dysregulated P13K/AKT, ERK 1/2 and SAPK/JNK levels. Immunobiology, v. 225, n. 2, MAR 2020. Web of Science Citations: 0. (14/05214-1, 17/11540-7, 10/02272-0)
KNOX DE SOUZA, PAULA R.; FERREIRA, SABRINA S.; NUNES, FERNANDA P. B.; CASAGRANDE, FELIPE B.; TESSARO, FERNANDO H. G.; SILVA, MARIANA C. F.; MIRANDA COSTA CRUZ, JOSE WALBER; MAMIZUKA, ELSA M.; MARTINS, JOILSON O.. Cytokine and Adhesion Molecule Expression Induced by Different Strains of Staphylococcus aureus in Type 1 Diabetic Rats: Role of Insulin. FRONTIERS IN IMMUNOLOGY, v. 9, JAN 17 2019. Web of Science Citations: 0. (17/11540-7, 12/06652-7, 14/05214-1, 10/02272-0)
AYALA, THAIS SOPRANI; GALVAO TESSARO, FERNANDO HENRIQUE; JANNUZZI, GRASIELLE PEREIRA; BELLA, LEONARDO MENDES; FERREIRA, KAREN SPADARI; MARTINS, JOILSON O.. High Glucose Environments Interfere with Bone Marrow-Derived Macrophage Inflammatory Mediator Release, the TLR4 Pathway and Glucose Metabolism. SCIENTIFIC REPORTS, v. 9, AUG 7 2019. Web of Science Citations: 0. (14/05214-1, 17/11540-7)
BELLA, LEONARDO M.; FIERI, ISIS; TESSARO, FERNANDO H. G.; NOLASCO, EDUARDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; AZEVEDO, CAROLINA B.; MARTINS, JOILSON O.. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BIOMED RESEARCH INTERNATIONAL, 2017. Web of Science Citations: 2. (10/02272-0, 14/05214-1, 13/20904-1, 12/23998-4)
TESSARO, FERNANDO H. G.; AYALA, THAIS S.; MARTINS, JOILSON O.. Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus. BIOMED RESEARCH INTERNATIONAL, 2015. Web of Science Citations: 20. (10/02272-0)
RAJASEKARAN, SUBU SURENDRAN; KIM, JAEYOON; GABOARDI, GIAN-CARLO; GROMADA, JESPER; SHEARS, STEPHEN B.; DOS SANTOS, KAREN TIAGO; NOLASCO, EDUARDO LIMA; FERREIRA, SABRINA DE SOUZA; ILLIES, CHRISTOPHER; KOHLER, MARTIN; et al. Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells. CELLULAR SIGNALLING, v. 46, p. 120-128, JUN 2018. Web of Science Citations: 3. (10/02272-0, 14/05214-1, 17/11540-7)
TESSARO, FERNANDO H. G.; AYALA, THAIS S.; NOLASCO, EDUARDO L.; BELLA, LEONARDO M.; MARTINS, JOILSON O.. Insulin Influences LPS-Induced TNF-alpha and IL-6 Release Through Distinct Pathways in Mouse Macrophages from Different Compartments. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 42, n. 5, p. 2093-2104, 2017. Web of Science Citations: 5. (10/02272-0, 14/05214-1, 17/15625-7, 12/23998-4)
FERREIRA, SABRINA S.; NUNES, FERNANDA P. B.; CASAGRANDE, FELIPE B.; MARTINS, JOILSON O.. Insulin Modulates Cytokine Release, Collagen and Mucus Secretion in Lung Remodeling of Allergic Diabetic Mice. FRONTIERS IN IMMUNOLOGY, v. 8, JUN 9 2017. Web of Science Citations: 2. (14/05214-1, 12/06617-7, 10/02272-0)
GUIMARAES, JOAO PEDRO TORRES; FILGUEIRAS, LUCIANO RIBEIRO; MARTINS, JOILSON OLIVEIRA; JANCAR, SONIA. Leukotriene Involvement in the Insulin Receptor Pathway and Macrophage Profiles in Muscles from Type 1 Diabetic Mice. Mediators of Inflammation, 2019. Web of Science Citations: 0. (13/15719-0, 17/11540-7)
BARKER, CHRISTOPHER J.; TESSARO, FERNANDO HENRIQUE GALVAO; FERREIRA, SABRINA DE SOUZA; SIMAS, RAFAEL; AYALA, THAIS S.; KOHLER, MARTIN; RAJASEKARAN, SUBU SURENDRAN; MARTINS, JOILSON O.; DARE, ELISABETTA; BERGGREN, PER-OLOF. XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush. Diabetes, v. 70, n. 1, p. 111-118, JAN 2021. Web of Science Citations: 1. (10/02272-0, 14/05214-1, 17/11540-7)