CV Lattes
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Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP) (Institutional affiliation from the last research proposal) Birthplace: Itália
graduate at Química from Universidade de São Paulo (1985), master's at Biochemistry from Universidade de São Paulo (1989) and Ph.D. at Biochemistry from Universidade de São Paulo (1993). Has experience in Byophysics, focusing on Biophysics of Processes and Systems, acting on the following subjects: fosfatase alcalina, na,k-atpase, proteolipossomos, cinetica enzimatica and lipossomos. (Source: Lattes Curriculum)
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Despite the remarkable regenerative capacity of bone, pathological conditions and critical-sized injuries can hinder its efficient repair. In this context, bone tissue engineering has emerged as a crucial research area in regenerative medicine. Recently, extracellular matrix vesicles (MVs), utilized as a cell-free therapy, have emerged as a promising strategy for regenerative medicine. Ho…
Extracellular vesicles (EVs) has been related to a wide kind of function like developments in immunology, angiogenesis, and stem-cells biology, as well as several pathologies. EVs are bioactive organelles that can carry genetic information, lipids, proteins, and nucleic acids between cells, inducing many molecular functions associated with signalization and regulation of gene expression i…
Extracellular Vesicles (EVs) have been related to a wide kind of function like developments in immunology, angiogenesis, and stem-cells biology, as well as several pathologies. EVs are bioactive organelles that can carry genetic information, lipids, proteins, and nucleic acids between cells, inducing many molecular functions associated with signalization and regulation of gene expression …
The FFCLRP has radically changed the RTI resource funding investment, according to the guidelines from the FAPESP advice in previous requests investing without fragmenting the funds and in fact, focusing in collective investments with interdepartamental scope and consequently intercisciplinary. As of knowledge, FFCLRP is a heterogeneous unit, composed since 2010 of seven departaments (bio…
The FFCLRP has radically changed the RTI resource funding investment, according to the guidelines from the FAPESP advice in previous requests investing without fragmenting the funds and in fact, focusing in collective investments with interdepartamental scope and consequently intercisciplinary. As of knowledge, FFCLRP is a heterogeneous unit, composed since 2010 of seven departaments (bio…
The FFCLRP has radically changed the RTI resource funding investment, according to the guidelines from the FAPESP advice in previous requests investing without fragmenting the funds and in fact, focusing in collective investments with interdepartamental scope and consequently intercisciplinary. As of knowledge, FFCLRP is a heterogeneous unit, composed since 2010 of seven departaments (bio…
(Only some records are available in English at this moment)
Osteocompetent cells, such as hypertrophic chondrocytes, osteoblasts and odontoblasts, release a special class of extracellular vesicles called matrix vesicles (MVs) that are involved in the deposition of apatite minerals at the sites of bone and tooth calcification. During the formation of physiological and pathological calcifications, MVs are believed to be released by outward budding o…
Due to long periods in space and exposure to considerable doses of radiation, astronauts sent on long-term missions tend to have bone problems when they return to the planet. Furthermore, osteoradionecrosis is a common sequelae of radiotherapy for head and neck cancer. One of the main problems described is the decrease in bone density, which can result in fragility and fractures. Despite …
Despite the remarkable regenerative capacity of bone, pathological conditions and critical-sized injuries can hinder its efficient repair. In this context, bone tissue engineering has emerged as a crucial research area in regenerative medicine. Recently, extracellular matrix vesicles (MVs), utilized as a cell-free therapy, have emerged as a promising strategy for regenerative medicine. Ho…
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
Mineralization of bone tissue is a highly ordered process that begins with the release of matrix vesicles (MV) from the plasma membrane of osteogenic cells, which are responsible for providing the necessary conditions for the nucleation and growth of the first calcium phosphate crystals, which are subsequently released into the organic matrix to propagate mineralization. Little is known a…
The biomineralization process occurs through the accumulation of mineral constituted mainly by phosphate and calcium ions which form the calcium phosphate salt with the structure of the hydroxiapatite. This process is mediated by osteoblasts, cells responsible for the beginning of the biomineralization process, mediated by release of the matrix vesicles (MVs). These vesicles arise from th…
| 3 / 3 | Ongoing grants |
| 20 / 11 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 17 / 12 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 49 / 35 | All research grants and scholarships |
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