CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmácia from Universidade Federal do Maranhão (1999), master's at Biochemistry from Universidade Estadual de Campinas (2002) and ph.d. at Biochemistry from Universidade Estadual de Campinas (2005). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: anestésicos locais, lipossomas, ciclodextrinas, anestesia and bioquímica. (Source: Lattes Curriculum)
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Most biomedical applications of nanostructures rely on the correlation between their physicochemical properties and modulation of biological effects. Some nanocarriers can recover their structural features after physical stress, providing mechanical resistance and bioadhesion, which are advantageous for skin delivery. However, their colloidal stability and bioactive release depend on inte…
Microneedles (MNs) form a safe and non-invasive drug-delivery platform for topic and systemic applications. Biocompatibility, easy application, improved efficiency-controlled release, and low concentrations needed are among the main benefits of the technology. Technologies based on MNs can increase the population's access to cutting-edge therapies through reduced costs and increase the we…
The drug administration on skin offers numerous advantages compared to traditional pathways such as local drug release, easy application and patient compliance, avoiding first-pass biotransformation. However, the stratum corneum complex structural organization is one of the main limitations to drug absorption. On the other hand, morphofunctional changes on stratum corneum are responsible …
The development of new carrier systems and modified release formulations have allowed the possible modulation of physical-chemical, pharmacodynamic and pharmacokinetic properties, enhancing the therapeutic effects and promoting the clinical use of different molecules. Among the various carrier systems, the self-assembled micelles, such as those formed by copolymers known as poloxamers. Th…
Local anesthetics (LA) are amphiphile compounds that interact with the sodium channel protein reversibly blocking the action potential of excitable membranes. The more potent the anesthetic (as for instance bupivacaine, which is the drug-of-choice for surgical procedures) the more toxic it is to the Central Nervous and Cardiovascular systems. Our research group has been working in the dev…
(Only some records are available in English at this moment)
This project proposes the development of a dual ROS-responsive, antiproliferative delivery systemincorporating EGCG and CAL into hydrogel-based polymeric MNs for improved psoriasis treatment. The specificobjectives include: (i) preparing and characterizing ROS-responsive nanoparticles in terms of colloidal properties, drug¿loading efficiency, thermodynamics, supramolecular organization, m…
This proposal aims to synthesize polymeric-lipid nanoparticles to incorporate hydrophobic molecules, such as Licochalcone A (LicA). On the other hand, the dispersion of these nanoparticles in microneedles promotes the formation of a complex system with three-dimensional macromolecular networks capable of encapsulating amphiphilic molecules such as sulforaphane (SFN). Considering the poten…
The development of novel prophylactic therapies is one of the main strategies to limit complications associated to the ZIKV infection, as well as are of particular interest between the infection and fetal abnormalities during the early stages of development. Herein, we propose the design and development of thermosensitive liposomes considering their lipid composition and physico-chemical …
(Only some records are available in English at this moment)
Kojic acid (KA) is a secondary metabolite produced by fungi and bactéria in aerobic fermentation conditions, using carbohydrates as substrates, being applied in several fields, such as food, industrial, agricultural, cosmetics and health. KA has well- described biological properties such as the ability to inhibit the production of tyrosinase and, consequently, melanin, in the treatment fo…
Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bio…
Organogels (ORG) are semi-solid systems, where an organic phase is immobilized by a three-dimensional network composed of self-assembled systems, forming the aqueous phase. In general, ORG have advantages over conventional systems (creams, ointments, hydrogels) such as modulation of skin permeation rate, as well as high affinity to the site of administration, according to their compositio…
(Only some records are available in English at this moment)
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense itching and recurrent eczematous lesions. Although the pathogenesis of this disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune abnormalities. The current therapies fo…