CV Lattes
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ORCID
Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmácia from Universidade Federal do Maranhão (1999), master's at Biochemistry from Universidade Estadual de Campinas (2002) and ph.d. at Biochemistry from Universidade Estadual de Campinas (2005). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: anestésicos locais, lipossomas, ciclodextrinas, anestesia and bioquímica. (Source: Lattes Curriculum)
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The drug administration on skin offers numerous advantages compared to traditional pathways such as local drug release, easy application and patient compliance, avoiding first-pass biotransformation. However, the stratum corneum complex structural organization is one of the main limitations to drug absorption. On the other hand, morphofunctional changes on stratum corneum are responsible …
The development of new carrier systems and modified release formulations have allowed the possible modulation of physical-chemical, pharmacodynamic and pharmacokinetic properties, enhancing the therapeutic effects and promoting the clinical use of different molecules. Among the various carrier systems, the self-assembled micelles, such as those formed by copolymers known as poloxamers. Th…
Local anesthetics (LA) are amphiphile compounds that interact with the sodium channel protein reversibly blocking the action potential of excitable membranes. The more potent the anesthetic (as for instance bupivacaine, which is the drug-of-choice for surgical procedures) the more toxic it is to the Central Nervous and Cardiovascular systems. Our research group has been working in the dev…
(Only some records are available in English at this moment)
Kojic acid (KA) is a secondary metabolite produced by fungi and bactéria in aerobic fermentation conditions, using carbohydrates as substrates, being applied in several fields, such as food, industrial, agricultural, cosmetics, and health. KA has well-described biological properties such as the ability to inhibit the production of tyrosinase and, consequently, melanin, in the treatment of…
Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bio…
Organogels (ORG) are semi-solid systems, where an organic phase is immobilized by a three-dimensional network composed of self-assembled systems, forming the aqueous phase. In general, ORG have advantages over conventional systems (creams, ointments, hydrogels) such as modulation of skin permeation rate, as well as high affinity to the site of administration, according to their compositio…
Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bio…
(Only some records are available in English at this moment)
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense itching and recurrent eczematous lesions. Although the pathogenesis of this disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune abnormalities. The current therapies fo…
| 5 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 11 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 18 / 17 | All research grants and scholarships |
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