Elisa Mitiko Kawamoto Iwashe
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Farmácia Bioquímica from Universidade de São Paulo (1999), master's at Pharmacology from Universidade de São Paulo (2002), doctorate at Pharmacology from Universidade de São Paulo (2006) and doctorate at Estágio sanduíche from National Institute On Aging (2006). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: nf-kb, stress, na,k-atpase, envelhecimento and doença de alzheimer. (Source: Lattes Curriculum)
- Evaluation of physical exercise effects on cognition of neuronal-PTEN deleted animals, AP.R
Abstract
PTEN (Phosphatase and tensin homolog on chromosome ten) is known as a tumor suppressor with its roles related or not to its phosphatase activity. Studies have been focused to investigate mechanisms relating PTEN to tumorigenesis. However, due to the broad characteristics of this phosphatase which is able to influence cellular proliferation, survival and migration, PTEN seems also to pla...
- Evaluation of PTEN compartmentalization on neurogenesis and synaptic plasticity influenced by environmental factors, AP.JP
Abstract
Studies have suggested that both genetic and environmental factors can affect neurogenesis and synaptic plasticity. For example, dietary restriction and physical exercise have both shown to exert beneficial effects in processes associated with aging, as well as cardiovascular, neurodegenerative, and endocrine diseases (i.e. diabetes). A better understanding of the underlying signaling m...
- Wnt signaling and protein-induced amyloid-beta peptide neurotoxicity in primary hippocampal neuronal cultures, AP.PRIM
(Only some records are available in English at this moment)
- Study of the modulator role of Klotho protein in neuroinflammatory signaling in mice, BP.PD
Abstract
The increase in life expectancy of the world population creates the need for understanding the aging process. This process induces alterations in organic functions at different levels of biological complexity which are directly related to the appearance of diseases. In the 90s, the discovery of a deletion in the gene that encodes the Klotho protein, in rodents, was shown to drastically ...
- Evaluation of aerobic exercise effects on cognition of neuronal-PTEN deleted mice, BP.MS
Abstract
The objective of this project is to study the altered signaling pathway of PTEN (phosphatase and tensin homolog deleted on chromosome 10), related to some pathologies of the central nervous system (CNS), such as the Autism Spectrum Disorder (ASD), among others. The attention on ASD has been growing as more research is being made about it, demanding data gathering for improvement attempt...
- Evaluation of the effects of the Klotho protein on the neuronal morphological alteration characteristics of the lack of PTEN protein, BP.MS
Abstract
Previous data indicate that the lack of PTEN protein leads to morphological alterations, which generate dysfunction in the neuronal development that commits its normal function. Understanding these mechanisms and the pathways to reverse or retard this process can result in benefits in the treatment and prevention of diseases related to the Central Nervous System (CNS).PTEN (Phosphatase ...
- Evaluation of the effects of PTEN compartmentalization in human cells of glioblastoma (U87MG)SUBMITTED to a inflammatory stimuli, BP.MS
Abstract
Evidences have expanded the concept that neuroinflammation is a causal and exacerbating component of neurodegenerative diseases. As resident cell of immune system in central nervous system (CNS), microglia acts as sensitive element and primary defense line against pro-inflammatory stimuli. Is is now becoming clear that the release of pathological levels of cytotoxic substances, such as ...
- Evaluation of the PTEN signaling effects over neurogenesis and cognition of mice under a physical exercise regimen, BP.MS
Abstract
First characterized as a tumor suppressor, the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) on other cellular processes - such as proliferation, migration and survival - has been assessed more recently, showing a potential modulatory effect over neurogenesis and synaptic plasticity.The hippocampus is an important region for cognition - with a crucial function o...
(Only some records are available in English at this moment)
- Developing new tools to study the relationship between PTEN and Klotho expression by molecular biological approaches, BE.EP.MS
Abstract
PTEN, which is essential for embryonic development, is a protein capable of controlling cell growth and proliferation by acting through the PI3K/AKT pathway. Since it has several roles in the development of the central nervous system (CNS), PTEN deletion has been associated with some neurological disorders. In turn, Klotho is a protein associated with longevity that has received increas...
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 7 / 7 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 15 / 14 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 5 |
| Citations | 73 |
| Cit./Article | 14.6 |
| Data from Web of Science | |
CARARO-LOPES, MARINA MINTO; YOKOYAMA MAZUCANTI, CAIO HENRIQUE; SCAVONE, CRISTOFORO; KAWAMOTO, ELISA MITIKO; BERWICK, DANIEL CHARLES. The relevance of alpha-KLOTHO to the central nervous system: Some key questions. AGEING RESEARCH REVIEWS, v. 36, p. 137-148, JUL 2017. Web of Science Citations: 12. (13/10787-8, 16/07427-8, 11/21308-8, 14/14199-6)
GLEZER‚ I.; MUNHOZ‚ C.D.; KAWAMOTO‚ E.M.; MARCOURAKIS‚ T.; AVELLAR‚ M.C.W.; SCAVONE‚ C.. MK-801 and 7-Ni attenuate the activation of brain NF-[kappa] B induced by LPS. Neuropharmacology, v. 45, n. 8, p. 1120-1129, 2003. (02/03506-8)
VASCONCELOS, ANDREA R.; YSHII, LIDIA M.; VIEL, TANIA A.; BUCK, HUDSON S.; MATTSON, MARK P.; SCAVONE, CRISTOFORO; KAWAMOTO, ELISA M.. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. JOURNAL OF NEUROINFLAMMATION, v. 11, MAY 6 2014. Web of Science Citations: 59. (09/11915-4, 06/57729-9)
CABRAL-COSTA, J. V.; ANDREOTTI, D. Z.; MELLO, N. P.; SCAVONE, C.; CAMANDOLA, S.; KAWAMOTO, E. M.. Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice. SCIENTIFIC REPORTS, v. 8, JUN 5 2018. Web of Science Citations: 0. (16/22996-9, 13/20594-2, 15/25491-2, 11/21308-8, 14/18689-8)
KINOSHITA, PAULA F.; YSHII, LIDIA M.; ORELLANA, ANA MARIA M.; PAIXAO, AMANDA G.; VASCONCELOS, ANDREA R.; LIMA, LARISSA DE SA; KAWAMOTO, ELISA M.; SCAVONE, CRISTOFORO. Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. SCIENTIFIC REPORTS, v. 7, JUL 7 2017. Web of Science Citations: 2. (11/04327-9, 14/05026-0, 16/07376-4, 11/22844-0, 11/21308-8, 11/10303-5, 11/12255-8)
DE MOLLO, NATALIA PRUDENTE; ORELLANA, ANA MARIA; MAZUCANTI, CAIO HENRIQUE; LIMA, GEOVANNI DE MORALS; SCAVONE, CRISTOFORO; KAWAMOTO, ELISE MITIKO. Insulin and Autophagy in Neurodegeneration. FRONTIERS IN NEUROSCIENCE, v. 13, MAY 22 2019. Web of Science Citations: 0. (16/22996-9, 16/07427-8)