CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina de Jundiaí (1983), master's at Clinical Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1993) and doctorate at Clinical Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1999). Has experience in Medicine, focusing on Clinical Medicine, acting on the following subjects: insuficiência cardíaca, rato, músculo papilar, função miocárdica and infarto do miocárdio. (Source: Lattes Curriculum)
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The project aims to acquire equipment and accessories for the infrastructure and biosecurity of the Centralized Multi-User Unit of the Botucatu School of Medicine (FMB) of the São Paulo State University, UNESP, called the "Animal Experimentation Research Unit, UPEA". Since the creation of the FMB Experimental Laboratories in the 1970s, its researchers have worked in animal facilities and …
The project aims to acquire an echocardiograph to equip the Centralized Multi-User Laboratory of the Botucatu Medical School (FMB) of the University of Sao Paulo State, UNESP, called UNIPEX. The FMB has an Experimental Research Unit, UNIPEX, and an Animal Experimentation Research Unit, UPEA, financed with support from the public calls MCT/FINEP/Ação Transversal Pro-Infra 01/2007 and MCT/F…
Cardiovascular diseases have high morbidity and mortality rates, with heart failure (HF) being one of the main causes of death in the world. A 46% increase in the prevalence of HF is expected for the year 2030 in relation to 2012. HF is characterized by decreased capacity for daily activities and physical exercise due to the early occurrence of fatigue or dyspnea resulting from ventricula…
Despite advances in the treatment of acute myocardial infarction (AMI), the high morbidity and mortality after AMI suggest that pathophysiological mechanisms remain unknown. Myocyte necrosis triggers inflammation, which is followed by a chronic process of cardiac remodeling. The inflammatory process is initiated when pattern recognition receptors (PRRs) of innate immune and myocardial res…
Introduction: We compared the influence of aerobic and resistance exercise on cardiac remodeling, physical capacity, and skeletal muscle oxidative stress in rats with MI-induced heart failure. Methods: Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S-MI); aerobic exercised MI (A-MI); and resistance exercised MI (R-MI). Exercised rats traine…
(Only some records are available in English at this moment)
Cardiovascular diseases have high morbidity and mortality rates, with heart failure (HF) being one of the main causes of death in the world. A 46% increase in the prevalence of HF is expected for the year 2030 in relation to 2012. HF is characterized by decreased capacity for daily activities and physical exercise due to the early occurrence of fatigue or dyspnea resulting from ventricula…
Heart failure induces fatigue and dyspnea. The symptoms are caused not only by cardiovascular and pulmonary abnormalities, but also by skeletal muscle changes, which have been extensively reported in cardiac failure and named heart failure-induced skeletal myopathy. More recently, the metabolism of sphingolipids has emerged as an important feature of muscular biology. Ceramide is associat…
Na insuficiência cardíaca (IC) ocorre aumento do estresse oxidativo na musculatura esquelética. Entretanto, as fontes de geração de espécies reativas de oxigênio (EROs) e as vias de sinalização pelas quais o estresse oxidativo induz alterações da musculatura esquelética ainda não estão completamente esclarecidas. A NADPH oxidase constitui importante fonte geradora de EROs. Estudos sugerem…
(Only some records are available in English at this moment)
Several chronic diseases and conditions associated with prolonged muscle inactivity can induce muscle atrophy. Regardless the cause, skeletal muscle atrophy results in muscular weakness and a decreased quality of life. Mechanical unloading that occurs with limb casting, splinting, bed rest, and spaceflight result in a substantial loss of force generating capacity, linked to a decrease in …
Neste estudo, será avaliada a remodelação cardíaca que ocorre em ratos submetidos à redução aguda e crônica da carga de trabalho do coração. Após a introdução, na prática clínica, de sofisticados aparelhos para suporte hemodinâmico de pacientes com insuficiência cardíaca terminal, este assunto se tornou de grande interesse. A redução da carga cardíaca será induzida por transplante de cora…