CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina de Jundiaí (1983), master's at Clinical Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1993) and doctorate at Clinical Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1999). Has experience in Medicine, focusing on Clinical Medicine, acting on the following subjects: insuficiência cardíaca, rato, músculo papilar, função miocárdica and infarto do miocárdio. (Source: Lattes Curriculum)
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The project aims to acquire an echocardiograph to equip the Centralized Multi-User Laboratory of the Botucatu Medical School (FMB) of the University of Sao Paulo State, UNESP, called UNIPEX. The FMB has an Experimental Research Unit, UNIPEX, and an Animal Experimentation Research Unit, UPEA, financed with support from the public calls MCT/FINEP/Ação Transversal Pro-Infra 01/2007 and MCT/F…
Cardiovascular diseases have high morbidity and mortality rates, with heart failure (HF) being one of the main causes of death in the world. A 46% increase in the prevalence of HF is expected for the year 2030 in relation to 2012. HF is characterized by decreased capacity for daily activities and physical exercise due to the early occurrence of fatigue or dyspnea resulting from ventricula…
Despite advances in the treatment of acute myocardial infarction (AMI), the high morbidity and mortality after AMI suggest that pathophysiological mechanisms remain unknown. Myocyte necrosis triggers inflammation, which is followed by a chronic process of cardiac remodeling. The inflammatory process is initiated when pattern recognition receptors (PRRs) of innate immune and myocardial res…
Background: Skeletal muscle wasting is often observed in heart failure (HF). The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis is impaired in HF. In this study, we evaluated the effects of GH on soleus muscle and cardiac remodeling in rats with aortic stenosis (AS)-induced HF. Methods: AS was created by placing a stainless-steel clip on the ascending aorta. After clinicall…
Oxidative stress is increased in skeletal muscle during heart failure (HF) and can contribute to HF-associated skeletal myopathy. However, sources of reactive oxygen species (ROS) and signaling pathways involved in ROS-induced skeletal muscle changes are not completely established. NADPH oxidase is an important source of ROS. Studies have suggested that the signaling pathways of mitogen-a…
(Only some records are available in English at this moment)
Cardiovascular diseases have high morbidity and mortality rates, with heart failure (HF) being one of the main causes of death in the world. A 46% increase in the prevalence of HF is expected for the year 2030 in relation to 2012. HF is characterized by decreased capacity for daily activities and physical exercise due to the early occurrence of fatigue or dyspnea resulting from ventricula…
Heart failure induces fatigue and dyspnea. The symptoms are caused not only by cardiovascular and pulmonary abnormalities, but also by skeletal muscle changes, which have been extensively reported in cardiac failure and named heart failure-induced skeletal myopathy. More recently, the metabolism of sphingolipids has emerged as an important feature of muscular biology. Ceramide is associat…
Oxidative stress and imbalance between anabolic and catabolic processes are involved in heart failure-associated skeletal muscle changes. Several positive effects from aerobic exercise have been described in heart failure. However, despite recent studies reporting beneficial effects from resistive exercise, the mechanisms involved in its effects are not completely clear. Resistive exercis…
Chronic heart failure (HF) is characterized by a decreased exercise capacity with early fatigue and dyspnea. Several clinical and experimental studies have suggested that skeletal muscle abnormalities can contribute to these symptoms in heart failure patients. Changes of myosin heavy chain (MyHC) isoforms have been frequently observed in peripheral and respiratory muscles during heart fai…
(Only some records are available in English at this moment)
Several chronic diseases and conditions associated with prolonged muscle inactivity can induce muscle atrophy. Regardless the cause, skeletal muscle atrophy results in muscular weakness and a decreased quality of life. Mechanical unloading that occurs with limb casting, splinting, bed rest, and spaceflight result in a substantial loss of force generating capacity, linked to a decrease in …
| 3 / 3 | Ongoing grants |
| 13 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 18 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 37 / 21 | All research grants and scholarships |
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