CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina de Jundiaí (1983), master's at Clinical Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1993) and doctorate at Clinical Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1999). Has experience in Medicine, focusing on Clinical Medicine, acting on the following subjects: insuficiência cardíaca, rato, músculo papilar, função miocárdica and infarto do miocárdio. (Source: Lattes Curriculum)
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Background: Skeletal muscle wasting is often observed in heart failure (HF). The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis is impaired in HF. In this study, we evaluated the effects of GH on soleus muscle and cardiac remodeling in rats with aortic stenosis (AS)-induced HF. Methods: AS was created by placing a stainless-steel clip on the ascending aorta. After clinicall…
Oxidative stress is increased in skeletal muscle during heart failure (HF) and can contribute to HF-associated skeletal myopathy. However, sources of reactive oxygen species (ROS) and signaling pathways involved in ROS-induced skeletal muscle changes are not completely established. NADPH oxidase is an important source of ROS. Studies have suggested that the signaling pathways of mitogen-a…
(Only some records are available in English at this moment)
Heart failure induces fatigue and dyspnea. The symptoms are caused not only by cardiovascular and pulmonary abnormalities, but also by skeletal muscle changes, which have been extensively reported in cardiac failure and named heart failure-induced skeletal myopathy. More recently, the metabolism of sphingolipids has emerged as an important feature of muscular biology. Ceramide is associat…
Oxidative stress and imbalance between anabolic and catabolic processes are involved in heart failure-associated skeletal muscle changes. Several positive effects from aerobic exercise have been described in heart failure. However, despite recent studies reporting beneficial effects from resistive exercise, the mechanisms involved in its effects are not completely clear. Resistive exercis…
Chronic heart failure (HF) is characterized by a decreased exercise capacity with early fatigue and dyspnea. Several clinical and experimental studies have suggested that skeletal muscle abnormalities can contribute to these symptoms in heart failure patients. Changes of myosin heavy chain (MyHC) isoforms have been frequently observed in peripheral and respiratory muscles during heart fai…
(Only some records are available in English at this moment)
Several chronic diseases and conditions associated with prolonged muscle inactivity can induce muscle atrophy. Regardless the cause, skeletal muscle atrophy results in muscular weakness and a decreased quality of life. Mechanical unloading that occurs with limb casting, splinting, bed rest, and spaceflight result in a substantial loss of force generating capacity, linked to a decrease in …
| 13 / 7 | Completed research grants |
| 18 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 33 / 17 | All research grants and scholarships |
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 16 |
| Citations | 303 |
| Cit./Article | 18.9 |
| Data from Web of Science | |
MARIANA JANINI GOMES; LUANA URBANO PAGAN; MARINA POLITI OKOSHI. Non-Pharmacological Treatment of Cardiovascular Disease | Importance of Physical Exercise. Arquivos Brasileiros de Cardiologia, v. 113, n. 1, p. 9-10, Jul. 2019. (14/21972-3, 14/23592-3)
MARTINEZ, PAULA F.; OKOSHI, KATASHI; ZORNOFF, LEONARDO A. M.; OLIVEIRA, JR., SILVIO A.; CAMPOS, DIJON H. S.; LIMA, ALINE R. R.; DAMATTO, RICARDO L.; CEZAR, MARCELO D. M.; BONOMO, CAMILA; GUIZONI, DANIELE M.; et al. Echocardiographic detection of congestive heart failure in postinfarction rats. Journal of Applied Physiology, v. 111, n. 2, p. 543-551, AUG 2011. Web of Science Citations: 41.
DAMATTO, R. L.; LIMA, A. R. R.; MARTINEZ, P. F.; CEZAR, M. D. M.; OKOSHI, K.; OKOSHI, M. P.. Myocardial myostatin in spontaneously hypertensive rats with heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 215, p. 384-387, JUL 15 2016. Web of Science Citations: 10. (12/50512-5)
GUIZONI, DANIELE M.; OLIVEIRA-JUNIOR, SILVIO A.; NOOR, SEFORA L. R.; PAGAN, LUANA U.; MARTINEZ, PAULA F.; LIMA, ALINE R. R.; GOMES, MARIANA J.; DAMATTO, RICARDO L.; CEZAR, MARCELO D. M.; BONOMO, CAMILA; et al. Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 221, p. 406-412, OCT 15 2016. Web of Science Citations: 12. (10/02077-2, 12/21687-1)
LIMA, ALINE R. R.; PAGAN, LUANA U.; DAMATTO, RICARDO L.; CEZAR, MARCELO D. M.; BONOMO, CAMILA; GOMES, MARIANA J.; MARTINEZ, PAULA F.; GUIZONI, DANIELE M.; CAMPOS, DIJON H. S.; DAMATTO, FELIPE C.; et al. Effects of growth hormone on cardiac remodeling and soleus muscle in rats with aortic stenosis-induced heart failure. ONCOTARGET, v. 8, n. 47, p. 83009-83021, OCT 10 2017. Web of Science Citations: 2. (12/50512-5, 09/54102-3)
GOMES, MARIANA J.; PAGAN, LUANA U.; LIMA, ALINE R. R.; REYES, DAVID R. A.; MARTINEZ, PAULA F.; DAMATTO, FELIPE C.; PONTES, THIERRES H. D.; RODRIGUES, EDER A.; SOUZA, LIDIANE M.; TOSTA, INGRID F.; et al. Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 24, n. 9, APR 2020. Web of Science Citations: 1. (14/23592-3)
RUIZ LIMA, ALINE REGINA; MARTINEZ, PAULA FELIPPE; OKOSHI, KATASHI; GUIZONI, DANIELE MENDES; MAMEDE ZORNOFF, LEONARDO A.; SALOME CAMPOS, DIJON HENRIQUE; OLIVEIRA, JR., SILVIO ASSIS; BONOMO, CAMILA; DAL PAI-SILVA, MAELI; OKOSHI, MARINA POLITI. Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure. International Journal of Experimental Pathology, v. 91, n. 1, p. 54-62, FEB 2010. Web of Science Citations: 34.
MARTINEZ, PAULA F.; BONOMO, CAMILA; GUIZONI, DANIELE M.; OLIVEIRA JUNIOR, SILVIO A.; DAMATTO, RICARDO L.; CEZAR, MARCELO D. M.; LIMA, ALINE R. R.; PAGAN, LUANA U.; SEIVA, FABIO R.; BUENO, RENATA T.; et al. Modulation of MAPK and NF-kappa B Signaling Pathways by Antioxidant Therapy in Skeletal Muscle of Heart Failure Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 39, n. 1, p. 371-384, 2016. Web of Science Citations: 13. (12/07149-7, 12/21687-1)
GOMES, MARIANA JANINI; MARTINEZ, PAULA FELIPPE; SALOME CAMPOS, DIJON HENRIQUE; PAGAN, LUANA URBANO; BONOMO, CAMILA; RUIZ LIMA, ALINE REGINA; DAMATTO, RICARDO LUIZ; CEZAR, MARCELO D. M.; DAMATTO, FELIPE CEZAR; ROSA, CAMILA MORENO; et al. Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016. Web of Science Citations: 22. (12/22485-3, 12/21687-1)
RUIZ LIMA, ALINE REGINA; MARTINEZ, PAULA FELIPPE; DAMATTO, RICARDO LUIZ; MARIANO CEZAR, MARCELO DIARCADIA; GUIZONI, DANIELE MENDES; BONOMO, CAMILA; OLIVEIRA, JR., SILVIO ASSIS; SILVA, MAELI DAL-PAI; MAMEDE ZORNOFF, LEONARDO ANTONIO; OKOSHI, KATASHI; et al. Heart Failure-Induced Diaphragm Myopathy. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 34, n. 2, p. 333-345, 2014. Web of Science Citations: 20.
GOMES, MARIANA JANINI; MARTINEZ, PAULA FELIPPE; PAGAN, LUANA URBANO; DAMATTO, RICARDO LUIZ; MARIANO CEZAR, MARCELO DIACARDIA; RUIZ LIMA, ALINE REGINA; OKOSHI, KATASHI; OKOSHI, MARINA POLITI. Skeletal muscle aging: influence of oxidative stress and physical exercise. ONCOTARGET, v. 8, n. 12, p. 20428-20440, 2017. Web of Science Citations: 38. (14/21972-3, 14/23592-3, 15/17539-5)
CEZAR, MARCELO D. M.; DAMATTO, RICARDO L.; PAGAN, LUANA U.; LIMA, ALINE R. R.; MARTINEZ, PAULA F.; BONOMO, CAMILA; ROSA, CAMILA M.; CAMPOS, DIJON H. S.; CICOGNA, ANTONIO C.; GOMES, MARIANA J.; et al. Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 36, n. 4, p. 1453-1466, 2015. Web of Science Citations: 20. (09/54102-3)
MARTINEZ, PAULA F.; OKOSHI, KATASHI; ZORNOFF, LEONARDO A. M.; CARVALHO, ROBSON F.; OLIVEIRA JUNIOR, SILVIO A.; LIMA, ALINE R. R.; CAMPOS, DIJON H. S.; DAMATTO, RICARDO L.; PADOVANI, CARLOS R.; NOGUEIRA, CELIA R.; et al. Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatiory factors. Medical Science Monitor, v. 16, n. 12, p. BR374-BR383, DEC 2010. Web of Science Citations: 33.
DAMATTO, R. L.; MARTINEZ, P. F.; LIMA, A. R. R.; CEZAR, M. D. M.; CAMPOS, D. H. S.; OLIVEIRA JUNIOR, S. A.; GUIZONI, D. M.; BONOMO, C.; NAKATANI, B. T.; DAL PAI SILVA, M.; et al. Heart failure-induced skeletal myopathy in spontaneously hypertensive rats. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 167, n. 3, p. 698-703, AUG 10 2013. Web of Science Citations: 29.
MARTINEZ, PAULA F.; BONOMO, CAMILA; GUIZONI, DANIELE M.; OLIVEIRA JUNIOR, SILVIO A.; DAMATTO, RICARDO L.; CEZAR, MARCELO D. M.; LIMA, ALINE R. R.; PAGAN, LUANA U.; SEIVA, FABIO R.; FERNANDES, DENISE C.; et al. Influence of N-Acetylcysteine on Oxidative Stress in Slow-Twitch Soleus Muscle of Heart Failure Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 35, n. 1, p. 148-159, 2015. Web of Science Citations: 19.
REYES, DAVID R. A.; GOMES, MARIANA J.; ROSA, CAMILA M.; PAGAN, LUANA U.; DAMATTO, FELIPE C.; DAMATTO, RICARDO L.; DEPRA, IGOR; CAMPOS, DIJON H. S.; FERNANDEZ, ANA A. H.; MARTINEZ, PAULA F.; et al. N-Acetylcysteine Influence on Oxidative Stress and Cardiac Remodeling in Rats During Transition from Compensated Left Ventricular Hypertrophy to Heart Failure. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 44, n. 6, p. 2310-2321, 2017. Web of Science Citations: 3. (14/21972-3)
REYES, DAVID R. A.; GOMES, MARIANA J.; ROSA, CAMILA M.; PAGAN, LUANA U.; ZANATI, SILMEIA G.; DAMATTO, RICARDO L.; RODRIGUES, EDER A.; CARVALHO, ROBSON F.; FERNANDES, ANA A. H.; MARTINEZ, PAULA F.; et al. Exercise during transition from compensated left ventricular hypertrophy to heart failure in aortic stenosis rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 23, n. 2, p. 1235-1245, FEB 2019. Web of Science Citations: 6. (14/21972-3)
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Mariana Janini. Influência do exercício físico sobre o estresse oxidativo, as MAPK e o NF-kB no músculo sóleo de ratos com insuficiência cardíaca induzida por estenose aórtica. 65 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (12/22485-3)
LIMA, Aline Regina Ruiz. Estudo do músculo diafragma em ratos com insuficiência cardíaca crônica : composição das miosinas e expressão dos fatores de regulação miogênica. 64 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (07/57499-6)
BONOMO, Camila. Resistência à insulina, hormônios tireoidianos e expressão protéica de glut4 no músculo esquelético de ratos com insuficiência cardíaca. 46 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (09/13564-4)
MARTINEZ, Paula Felippe. Estresse oxidativo e sinalização pelas vias MAPK e NF-кB no músculo sóleo de ratos com insuficiência cardíaca crônica. 88 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (07/59500-1)
GUIZONI, Daniele Mendes. Influência do exercício físico na expressão da miostatina e folistatina no músculo sóleo de ratos com insuficiência cardíaca crônica. 63 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (10/02077-2)
BONOMO, Camila. Efeito da inibição da NADPH oxidase sobre o estresse oxidativo e o fenótipo muscular esquelético de ratos com insuficiência cardíaca crônica induzida por estenose aórtica. 59 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (11/22589-0)
MARTINEZ, Paula Felippe. Expressão dos fatores de regulação miogênica, composição das miosinas e trofismos no músculo esquelético periférico de ratos com insuficiência cardíaca crônica. 71 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (05/58294-3)