Valeria Cristina Sandrim in research grants and scholarships supported by FAPESP.
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Preeclampsia is the main cause of mortality and morbidity among pregnant women in Brazil and in several countries. The pathophysiology of this disease is complex and involves several processes. One of them is related to deficiency of the nitric oxide (NO). A possible cause of this deficiency could be the high expression of the enzyme arginase, which competes for the substrate (L-arginine)…
Myeloperoxidase is a proinflammatory enzyme found to be increased in patients with established preeclampsia but never investigated before the disease onset. Here we examined myeloperoxidase concentration and activity in plasma and urine samples from pregnant women who remained normotensive throughout pregnancy and those who developed preeclampsia in order to assess its potential to predic…
(Only some records are available in English at this moment)
Preeclampsia (PE) is a hypertensive disorder that occurs after 20 weeks of gestation, whose main symptoms include proteinuria, liver damage, impaired clotting, among other signs and symptoms. Few treatment fronts are available and pregnant women who do not respond to antihypertensive therapy develop the worst clinical outcomes. Therefore, understanding the mechanisms by which endothelial …
Preeclampsia (PE) stands out as the main gestational hypertensive syndrome responsible for high rates of morbidity and mortality in Brazil and worldwide. The disease is characterized by hypertension (e140 / 90 mmHg), which in turn is often accompanied by proteinuria, in addition to dysfunction of target organs, such as kidneys and liver. The pathophysiology of PE is not yet fully elucidat…
Preeclampsia (PE) is a complex syndrome responsible for high maternal and perinatal morbidity and mortality in Brazil and worldwide. The causes and mechanisms by which this disease sets in have not been fully elucidated, however, it is believed that an abnormal implantation and placentation are responsible for generating a placental ischemia leading to a generalized endothelial dysfunctio…
Preeclampsia (PE) is a specific syndrome of a human pregnancy, being one of the main causes of maternal death in Brazil. The pathophysiology of PE has not been fully clarified, but it is known that placental ischemia is of fundamental importance to the process, since the release of products resulting from malperfusion in maternal circulation can lead to systemic endothelial dysfunction. A…
(Only some records are available in English at this moment)
Preeclampsia (PE) is a specific syndrome of human pregnancy and the clinical parameters that define it are well understood. However, given the severity for the mother and fetus and the confirmation of the diagnosis only after the twentieth week of gestation, many studies have evaluated the use of biomarkers, such as the ratio between sFlt-1 (soluble vascular endothelial growth factor rece…
| 1 / 0 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 11 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 25 / 20 | All research grants and scholarships |
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