CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Biologia Modalidade Médica Biomedicina from Universidade Federal do Pará (1989), master's at Pós-Graduação em Genética from Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (1993) and doctorate at Genetics from Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (1999). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: bioinformática, polimorfismo de dna, polimorfismo, expressão gênica and diversidade genética. (Source: Lattes Curriculum)
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The project proposes the establishment of a Zebrafish Multiuser Facility (EMU-Zebrafish) at the Center for Biomedical Sciences Research (CPCBio) of the Ribeirão Preto Medical School at the University of São Paulo (FMRP-USP). Zebrafish is currently recognized as a highly relevant vertebrate model in genetics, developmental biology, neuroscience, pharmacology, immunology, oncology, and toxi…
The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
Penile cancer, although considered rare in developed countries, has high rates in developing countries. In Brazil, the state of Maranhão has the highest national and global incidence of the disease ever recorded, followed by the states of Pará and Amazonas. The lack of knowledge about its genetic and molecular basis and the absence of targeted therapies that prevent progression to lymph n…
(Only some records are available in English at this moment)
HOX genes are a subgroup of the Homeobox family characterized by high degree of conservation among fungi, plants and animals. In mammals, there are 39 HOX genes distributed in four groups or clusters: HOXA, HOXB, HOXC and HOXD, located on chromosomes 2, 7, 17 and 12, respectively. HOX genes are transcription factors that act during embryonic development, regulating fundamental biological …
The HOX genes are a subset of the homeobox family, which are characterized by the high degree of conservation among fungi, plants, and animals. In mammals, the HOX genes are divided into four groups or gene clusters named of HOXA, HOXB, HOXC, and HOXD, and located on chromosomes 2, 7, 17 and 12, respectively. To date, 39 HOX genes have been identified, which act during embryonic developme…
(Only some records are available in English at this moment)
Glioblastoma (GBM) is the most common and lethal neoplasm that affects astrocytic cells, with extremely aggressive and invasive growth. It is marked by low survival rates, usually just over a year. In this tumor, there is an intense deregulation in gene expression, highlighting the up regulation of 33 HOX genes. Of these, we found that high levels of expression of the HOXB2 gene are corre…
Ovarian cancer is the most lethal gynecologic cancer, and most patients have a survive rate of fewer than five years after diagnosis, due to lack of symptoms in its early stages. Therefore, there is an urgent need to develop biomarkers to help diagnose ovarian cancer earlier. MicroRNAs (miRNAs) are small noncoding RNA molecules that act regulating critical biological processes such as dev…
Melanoma is a malignancy caused by accumulation of genetic alterations in melanocytes, and it is the deadliest form of skin cancer due to its high metastatic potential. The genetic basis of melanoma is well characterized, and activating mutations in the RAF/RAS pathway (i.e. BRAFV600E) combined with other genetic mutations, i.e. PTEN silencing, have been shown to induce metastatic melanom…
(Only some records are available in English at this moment)