Abstract
In order to discover new therapeutic targets, our research group selected hyperexpressed genes in glioblastomas (GBMs) compared to pilocytic astrocytoma (AGI) by microarray analysis. Among the selected genes, the gene called protein kinase MELK (Maternal Embryonic Leucine Zipper Kinase) showed a higher expression in GBMs compared to AGI. The increased expression of MELK was proportional t…