Graduate at Ciências Biológicas from Universidade Federal do Espírito Santo (1996), master's at Biochemistry from Universidade Federal de São Paulo (2000) and ph.d. at Biochemistry from Universidade Federal de São Paulo (2004). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: endothelial cell, celula endotelial, ej-ras, proteoglycans and heparam sulfato. (Source: Lattes Curriculum)
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During cancer progression, some events are important to trigger the metastasis process, such as extracellular matrix remodeling for survival after the absence of cell-extracellular matrix interaction, in a process denominated anoikis resistance. Previous work from our group has shown that anoikis-resistant endothelial cells show an increased in the sindecan-4 expression, a heparan sulfate…
The resistance of tumor cells to cell death by adhesion loss (anoikis) is a major cellular feature that contributes to tumor progression and metastasis. As a functional phenomenon, anoikis resistance is an important event in the metastatic cascade, a prerequisite for colonization and spread to distant sites. However, the mechanisms involved in anoikis regulation resistance are not fully e…
Syndecan-4 can act as co-receptor for growth factors and proteins of the extracellular matrix (ECM), increasing the affinity of these molecules to their specific receptors. Syndecan-4 participates in cell adhesion at focal contacts with integrins and FAK (focal adhesion kinase), connecting the ECM to cytoskeleton. Changes in the expression of syndecan-4 have been found in tumor cells, ind…
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Anoikis is a type of regulated cell death that occurs due to lack of cell adhesion to the extracellular matrix (ECM). Many tumor cells are resistant to anoikis, facilitating their invasion and contributing to tumor metastasis. Previous data from our laboratory showed that endothelial cells resistant to anokis show morphological changes, high proliferation rate, low adhesion to fibronectin…
Anoikis is a type of regulated cell death that occurs due to lack of adhesion or improper adhesion of the cell to the extracellular matrix (ECM). Many tumor cells are anoikis resistant; this facilitates the invasion of these cells and contributes to tumor metastasis. Previous data from our laboratory showed that anoikis-resistant endothelial cells show morphological changes, high prolifer…
Anoikis is a type of regulated cell death that occurs due to lack of adhesion or inadequate adhesion of the cell to the extracellular matrix (ECM). Many tumor cells are resistant to anoikis and this facilitates the invasion of these cells contributing to tumor metastasis. Although it is an important process, the mechanisms involved in regulating resistance to anoikis have not yet been ful…
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 9 / 8 | All research grants and scholarships |
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CV Lattes
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