Priscila Gava Mazzola in research grants and scholarships supported by FAPESP.
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Pressure ulcers are injuries to the skin or tissue that usually occur as a result of other diseases that lead to the patient's loss of mobility, which is bedridden, leading to pressure in a specific area and decreased blood circulation. These lesions have different levels of depth of damage caused to the skin, which can affect muscles and bones. This problem causes serious pain, impairing…
Burns present varying levels of tissue loss, leading to impairment of skin's functional integrity. Clinically, burns are classified in first, second and third degree lesions, according to the depth of tissue involvement. Adequate management of these lesions, mainly with the use of topical antimicrobial therapy, is of fundamental importance to avoid complications and to improve the surviva…
(Only some records are available in English at this moment)
This project seeks to develop a new system of natural preservatives, using coffee and rosemary extracts, to apply it in a pharmacopeic emulsion and compare its effectiveness with parabens. Parabens are preservatives widely used in the pharmaceutical industry, due to their broad-spectrum antimicrobial activity, compatibility with other ingredients and great cost-effectiveness. However, in …
Baru nuts (Dipteryx alata) and chia seeds (Salvia hispanica L.) are rich in antioxidant compounds such as polyphenols, tocopherols and triterpenes, unsaturated fatty acids and triacylglycerides. The production of baru and chia oils by mechanical extraction generates waste, which could be reused for the production of plant extracts and, in this way, reduce waste and environmental impact. T…
New release systems with permeation promoters for topical delivery are needed for the treatment of persistent diseases, where oral therapy causes adverse effects. Liposomes are promoters of biocompatible permeation and are successful on the market, but have the limitation of being subject to the oxidation of lipid membranes. Vegetable oils such as baru (Dipteryx alata Vog.) and chia (Salv…
(Only some records are available in English at this moment)
Burns are very common injuries in society and have varying levels of tissue loss, which can compromise the skin's functional integrity. In Brazil, they are recorded among the main external causes of death, and this is mainly due to infections that evolve with septicemia. Thus, proper management of these lesions is important, and an example is topical antimicrobial therapy in order to avoi…
Nanoparticles can be a carrier system of natural compounds, such as black pepper extract, effective and promising for helping and facilitating the bioavailability of compounds and encapsulated drugs. The black pepper extract is widely used in cooking, however it has a great medicinal potential already known in India for presenting healing, antioxidant, antimicrobial and antiparasitic prop…
The increased incidence of ultraviolet rays promoted the use of sunscreens to protect the skin. Studies point to the preventive potential of this cosmetic under the incidence of skin diseases. However, components of the sunscreens have high absorptive capacity, due to their molecular composition, and the adverse effects that such components could cause in the body are investigated. The ob…
(Only some records are available in English at this moment)
This proposal aims to develop fluconazole nanocrystals and incorporate them into foamable microemulsions, for the treatment of vaginal fungal infections. Antifungal treatments available can be long, uncomfortable, and do not reach the whole affected area, leave residues, and sometimes cause adverse effects as burning, itching, swelling, given the currently formulations developed. Keeping …
Radiotherapy is largely used in breast cancer treatment. However, in 98% of the patients, accumulation of ionizing radiation may occur in the skin, causing radiodermatitis. Therefore, it may be necessary to interrupt the treatment due to the impact on patient's quality of life. Besides, this wound can become a favorable environment for proliferation of pathogens. Thinking about that, usin…
The purpose of this proposal is to develop foamable microemulsions with fluconazole and nystatin complexed with beta-cyclodextrin as active pharmaceutical ingredients. Foamable microemulsions will be characterized for their physicochemical and foaming properties, release profile and antifungal activity as novel intravaginal treatments for vulvovaginal candidiasis (VVC). Current treatments…
This study aims to design, fabricate and characterize sponges containing polysaccharide microspheres loaded with Spondias mombin L. seed extract for treatment of pressure ulcer. Pressure ulcer is a skin damage that impairs the quality of life of patients, affecting their physical, emotional, mental and social well-being. Porous biomicrospheres (beads) and sponges will be developed using c…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 11 / 11 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 25 / 22 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 12 / 12 | Completed scholarships abroad |
| 55 / 52 | All research grants and scholarships |
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