CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Licenciatura/Bacharelado em Ciências Biológicas from Centro Universitário Fundação Santo André (2006), master's at Microbiology from Universidade Federal de São Paulo (2010) and doctorate at Immunology from Universidade de São Paulo (2014). Has experience in Immunology, focusing on Imunogenetics (Source: Lattes Curriculum)
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Animal experimentation models are the starting point of good scientific work, just as animal facilities with top-quality infrastructure contribute to the quality and reproducibility of research results. UFABC has been growing and consolidating its research groups in various areas of knowledge, particularly those involving the use of animal models, mostly rodents. The increasing demand fro…
Intestinal homeostasis is a product of a complex and regulated network among diet, microbiota, gut epithelial cells and the immune system. The great challenge for the gastrointestinal tract is to respond to pathogens and to food antigen while it needs to keep its function, such as nutrient absorption, and to tolerate foreign antigens. Any disturb between these interactions unleashes an in…
Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), are chronic disorders characterized by inflammation of the gastrointestinal tract, resulting in debilitating symptoms such as diarrhea, abdominal pain, and weight loss, significantly impacting patients' quality of life. The intestine plays a crucial role in both digestion and immune response, act…
Ulcerative colitis (UC) is currently the most common type of inflammatory bowel disease (IBD), with a prevalence of 5 million cases worldwide. Characterized by a dysregulated immune response, microbiota imbalance and damage to the intestinal epithelium, UC affects the colon and rectum. Macrophages are crucial for orchestrating immune responses in the intestinal epithelium and ensure intes…
Inflammatory bowel diseases have an increased incidence worldwide. They can occur due to several factors, from genetic to after infections by pathogenic microorganisms. Furthermore, intestinal inflammation may be associated with the development of colorectal cancer. Thus, it becomes important to understand the processes and components related to intestinal homeostasis as well as those rel…
Epidemiological studies have shown an association between obesity and autoimmune diseases. However, the immunologic mechanisms that explain this association have not been elucidated. The small intestine is one of the most important organs for the induction of peripheral tolerance; the intestinal immune system maintains the function of the organ while it responds to antigens from diet, pat…
Enteroendocrine hormones are hormones released from the activation of enteroendocrine cells (CEE), cells that reside in the epithelial layer of the gastrointestinal tract. CEEs release these hormones from the presence of nutrients. Among these hormones are the incretins GIP (Gastric Inhibitory Polypeptide) and GLP-1 (Glucagon-like Polypeptide 1). These two hormones have the ability to rel…
(Only some records are available in English at this moment)
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a leading cause of chronic kidney disease (CKD). Data from my PhD project indicate that chronic DSS-induced intestinal inflammation reduces the number of enteroendocrine cells (EECs) in the colon and predisposes to acute kidney injury (AKI) in an ischemia-reperfusion model. Several studies have highlighted a strong…
Short Chain Fatty Acids (SCFA) are end-products produced from the fermentation of complex carbohydrates by intestinal microbiota. It has been reported that AGCCs have anti-inflammatory properties, protecting from colitis as well as acting in modulation of neutrophil's function and in the maturation and activation of dendritic cells. However, their role in the function of T CD4 + cells, cr…