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Yara Cury

CV Lattes ResearcherID


Secretaria da Saúde (São Paulo - Estado). Instituto Butantan  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Dr. Cury holds a Master and a Doctorate in Sciences (Pharmacology, 1982 and 1986, respectively), from the University of São Paulo, Brazil. Her thesis focused on the hormonal control of the inflammatory response. Dr. Cury has been a Senior Researcher at the Butantan Institute, São Paulo, Brazil, since 1987 and Direct0r of the Scientific Development Division of Butantan Institute from 12/2012-04/2017. She has been studying the inflammatory/antiinflamatory and nociceptive/antinociceptive effects of animal venoms and toxins for long, aiming (i) to characterize the mechanisms involved in inflammation and pain observed in human envenomations, (ii) to use these toxins as tools for the understanding of the pathophysiology of pain and inflammation and their control, and also as tools for the development of experimental models for the study of both phenomena, (iii) to use these toxins as models for the development/design of new drugs for the treatment of pain and inflammation. Dr. Cury activities emphasize basic research and development. She also provides supervision for undergraduated and graduated students. She has published book chapters, review articles and more than 60 articles in peer-reviewed journals. Other activities include: member of the Research Council of Butantan Institute (1995-1997; and then since the beginning of 2012), member of the Ethics Committee for the Use of Animals in Research, Butantan Institute (CEUAIB) (2004-2011), Toxicon?s Mini-review editor, Member of the Board of Directors of the Brazilian Society on Toxinology (2009-2015), Councilor of the Brazilian Society on Toxinology (1999-2000; 2006-2009), Councilor of the Brazilian Society on Pharmacology and Experimental Therapeutics (2005-2011), Member of the Board of Directors of the Brazilian Society on Pharmacology and Experimental Therapeutics (2012-2014), Councilor of the International Society on Toxinology (since 2009). Dr. Cury is the Scientific Advisor of the MBA course in Gestão da Inovação em Saude, Butantan Institute. (Source: Lattes Curriculum)

Research grants
Scholarships in Brazil
Scholarships abroad
FAPESP support in numbers * Updated September 26, 2020
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (19)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications10
Citations172
Cit./Article17.2
Data from Web of Science

ZAHARENKO, ANDRE J.; PICOLO, GISELE; FERREIRA, JR., WILSON A.; MURAKAMI, TAKANORI; KAZUMA, KOHEI; HASHIMOTO, MASARU; CURY, YARA; DE FREITAS, JOSE C.; SATAKE, MOTOYOSHI; KONNO, KATSUHIRO. Bunodosine 391: An Analgesic Acylamino Acid from the Venom of the Sea Anemone Bunodosoma cangicum. Journal of Natural Products, v. 74, n. 3, p. 378-382, . Web of Science Citations: 18. (09/08089-5, 08/01988-1)

CHACUR, M.; LONGO, I.; PICOLO, G.; GUTIÉRREZ, J. M.; LOMONTE, B.; GUERRA, J. L.; TEIXEIRA, C. F. P.; CURY, Y.. Hyperalgesia induced by Asp49 and Lys49 phospholipases A(2) from Bothrops asper snake venom: pharmacological mediation and molecular determinants. Toxicon, v. 41, n. 6, p. 667-678, .

ZAHARENKO, ANDRE JUNQUEIRA; SCHIAVON, EMANUELE; FERREIRA, JR., WILSON ALVES; LECCHI, MARZIA; DE FREITAS, JOSE CARLOS; RICHARDSON, MICHAEL; WANKE, ENZO. Characterization of selectivity and pharmacophores of type 1 sea anemone toxins by screening seven Na-v sodium channel isoforms. Peptides, v. 34, n. 1, SI, p. 158-167, . Web of Science Citations: 7.

GUTIERREZ, VANESSA P.; ZAMBELLI, VANESSA O.; PICOLO, GISELE; CHACUR, MARUCIA; SAMPAIO, SANDRA C.; BRIGATTE, PATRICIA; KONNO, KATSUHIRO; CURY, YARA. The peripheral L-arginine-nitric oxide-cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic pain in rats. Behavioural Pharmacology, v. 23, n. 1, p. 14-24, . Web of Science Citations: 18. (98/14307-9, 07/02478-4, 07/00135-2, 08/57898-0)

CHACUR‚ M.; PICOLO‚ G.; TEIXEIRA‚ CFP; CURY‚ Y.. Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom. Toxicon, v. 40, n. 7, p. 1047-1051, .

CHACUR‚ M.; GUTIÉRREZ‚ J. M.; MILLIGAN‚ E. D.; WIESELER-FRANK‚ J.; BRITTO‚ L. R. G.; MAIER‚ S. F.; WATKINS‚ L. R.; CURY‚ Y.. Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators. Pain, v. 111, n. 1-2, p. 65-76, .

FERREIRA JUNIOR, WILSON ALVES; ZAHARENKO, ANDRE JUNQUEIRA; KAZUMA, KOHEI; PICOLO, GISELE; GUTIERREZ, VANESSA PACCIARI; DE FREITAS, JOSE CARLOS; KONNO, KATSUHIRO; CURY, YARA. Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391. TOXINS, v. 10, n. 1, . Web of Science Citations: 1. (09/08089-5, 11/01183-6, 13/07467-1)

VANESSA OLZON ZAMBELLI; LUCIMARA CHIOATO; VANESSA PACCIARI GUTIERREZ; RICHARD JOHN WARD; YARA CURY. Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 23, p. -, .

ZAMBELLI, VANESSA OLZON; DE OLIVEIRA FERNANDES, ANA CAROLINA; GUTIERREZ, VANESSA PACCIARI; BATISTA FERREIRA, JULIO CESAR; PARADA, CARLOS AMILCAR; MOCHLY-ROSEN, DARIA; CURY, YARA. Peripheral Sensitization Increases Opioid Receptor Expression and Activation by Crotalphine in Rats. PLoS One, v. 9, n. 3, . Web of Science Citations: 10. (07/00135-2, 08/57898-0)

ZAMBELLI, VANESSA O.; GROSS, ERIC R.; CHEN, CHE-HONG; GUTIERREZ, VANESSA P.; CURY, YARA; MOCHLY-ROSEN, DARIA. Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Science Translational Medicine, v. 6, n. 251, . Web of Science Citations: 32. (11/08873-8, 13/07467-1, 12/05035-4)

KONNO, KATSUHIRO; PICOLO, GISELE; GUTIERREZ, VANESSA P.; BRIGATTE, PATRICIA; ZAMBELLI, VANESSA O.; CAMARGO, ANTONIO C. M.; CURY, YARA. Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus. Peptides, v. 29, n. 8, p. 1293-1304, . Web of Science Citations: 39. (07/00135-2)

GUTIERREZ, VANESSA PACCIARI; KONNO, KATSUHIRO; CHACUR, MARUCIA; SAMPAIO, SANDRA COCCUZZO; PICOLO, GISELE; BRIGATTE, PATRICIA; ZAMBELLI, VANESSA OLZON; CURY, YARA. Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors. European Journal of Pharmacology, v. 594, n. 1-3, p. 84-92, . Web of Science Citations: 31. (07/00135-2)

G. PICOLO; M. CHACUR; J.M. GUTIÉRREZ; C.F.P. TEIXEIRA; Y. CURY. Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms. Brazilian Journal of Medical and Biological Research, v. 35, n. 10, p. 1221-1228, .

CHACUR‚ M.; PICOLO‚ G.; GUTIÉRREZ‚ JM; TEIXEIRA‚ CFP; CURY‚ Y.. Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. Toxicon, v. 39, n. 8, p. 1173-1181, .

TEIXEIRA, C. F. P.; LANDUCCI, E. C. T.; ANTUNES, E.; CHACUR, M.; CURY, Y.. Inflammatory effects of snake venom myotoxic phospholipases A(2). Toxicon, v. 42, n. 8, p. 947-962, .

ZAMBELLI, VANESSA OLZON; CHIOATO, LUCIMARA; GUTIERREZ, VANESSA PACCIARI; WARD, RICHARD JOHN; CURY, YARA. Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A(2). Journal of Venomous Animals and Toxins including Tropical Diseases, v. 23, n. 1, . Web of Science Citations: 5.

BRESSAN, ELISANGELA; TOUSKA, FILIP; VETTER, IRINA; KISTNER, KATRIN; KICHKO, TATJANA I.; TEIXEIRA, NATHALIA B.; PICOLO, GISELE; CURY, YARA; LEWIS, RICHARD J.; FISCHER, MICHAEL J. M.; et al. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, v. 157, n. 11, p. 2504-2516, . Web of Science Citations: 11. (13/07467-1, 08/57898-0, 12/51458-4, 98/14307-9)

CHACUR‚ M.; MILLIGAN‚ E.D.; SLOAN‚ E.M.; WIESELER-FRANK‚ J.; BARRIENTOS‚ R.M.; MARTIN‚ D.; POOLE‚ S.; LOMONTE‚ B.; GUTIÉRREZ‚ J.M.; MAIER‚ S.F.; et al. Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia‚ proinflammatory cytokines and nitric oxide. Pain, v. 108, n. 1, p. 180-191, .

ZANCHET‚ E.M.; LONGO‚ I.; CURY‚ Y.. Involvement of spinal neurokinins‚ excitatory amino acids‚ proinflammatory cytokines‚ nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom. Brain Research, v. 1021, n. 1, p. 101-111, .

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CHACUR, Marucia. Efeito nociceptivo induzido por fosfolipases A2 (FLA2 variantes Lys49 e Asp49) isoladas do veneno de serpentes Bothrops asper: caracterização dos mecanismos centrais e determinantes moleculares.  195 f. Tese (Doutorado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (00/12303-8

ZARZANA, Eduardo Cesar. Crotoxina: uma nova abordagem na inflamação alérgica pulmonar em ratos.. Tese (Doutorado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (06/04667-6

ZAMBELLI, Vanessa Olzon. Avaliação da expressão e ativação de receptores opióides após injúria periférica em ratos.. Tese (Doutorado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (07/00135-2

Patent applications

ANALGESIC PEPTIDES DERIVED FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUSS SNAKES CA2565731 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 06

ANALGESIC COMPOUNDS CA2685720 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Laboratório Biosintética Ltda; Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno - April 2008, 30

ANALGESIC PEPTIDES DERIVED FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUSS SNAKES CN200580021319 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 06

ANALGESIC COMPOUNDS CN200880023231 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Laboratório Biosintética Ltda; Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno - April 2008, 30

ANALGESIC PEPTIDES DERIVED FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUSS SNAKES EP20050738454 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 06

ANALGESIC COMPOUNDS EP20080733530 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Laboratório Biosintética Ltda; Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno - April 2008, 30

COMPUESTOS ANÁLOGOS DE PÉPTIDOS ANALGÉSICOS DERIVADOS DEL VENENO DE SERPIENTES CROTALUS DURISSUS TERRIFICUS, SUS USOS, COMPOSICIONES, PROCEDIMIENTOS DE PREPARACIÓN Y PURIFICACIÓN ES2377635 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 06

ANALGESIC PEPTIDES DERIVED FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUSS SNAKES PCT/BR2005/000073 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 06

ANALGESIC COMPOUNDS PCT/BR2008/000127 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Laboratório Biosintética Ltda; Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno - April 2008, 30

COMPOSTOS ANÁLOGOS A PEPTÍDEOS ANALGÉSICOS DERIVADOS DE VENENO DE SERPENTES CROTALUS DURISSUS TERRIFICUS, SEUS USOS, COMPOSIÇÕES, MÉTODOS DE PREPARAÇÃO E DE PURUFICAÇÃO PI0502399-8 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 02

PROCESSO DE SINTESE E COMPOSIÇÕES FARMACÊUTICAS DE PEPTÍDEOS E ANÁLOGOS, DERIVADOS DO VENENO DE SERPENTES POR EXEMPLO, DO GÊNERO CROTALUS, COM ATIVIDADE ANALGÉSICA, USOS E PRODUTOS ASSOCIADOS PI0401702-1 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Laboratório Biosintética Ltda; Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno - May 2004, 06

ANALGESIC PEPTIDES DERIVED FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUSS SNAKES US11/579,615 - Biosintética Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Yara Cury. Yara Cury; Gisele Picolo; Katsuhiro Konno; Renata Giorgi; Patrícia Brigatte; Vanessa Pacciari Gutierrez; Antônio Carlos Martins de Camargo - May 2005, 06

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