Alzir Azevedo Batista
CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Química from Universidade dos Povos Patrice Lumumba (1973), master's at Chemistry from Universidade de São Paulo (1978) and ph.d. at Chemistry from Universidade de São Paulo (1982). Has experience in Chemistry, focusing on Inorganic Chemistry, acting on the following subjects: ruthenium, rutênio, rutenio, eletroquímica and x-ray structure. (Source: Lattes Curriculum)
- Metal complexes with dirivative ligands of lawsone and acylthioureas, with anticancer potential activities: study in vitro and in vivo, AP.R
Abstract
AbstractIn the search for new coordination compounds with antitumor, and without toxicity, or with less toxicity than the platinum based-compounds, ruthenium compounds are very promising. Thus, it is necessary to evaluate the antitumor potentiality of these new compounds and try to understand the possible relationship between the intracelular localization of the compounds and their me...
- Cytotoxicity and mechanism of action of ruthenium complexes containing natural products or derivatives, AP.R
Abstract
The present project aims the syntheses of four series of ruthenium complexes containing diphosphines and diimines, as well natural products or derivatives as ligands.Series 1: Compounds with general formula [Ru(O-O)(dppb)(bipy)]PF6, where O-O = galic acid, cinamic acid, salicilic acid or 4-aminosalicilic acid and derivatives;Série 2: Compounds with general formula [Ru(O-O)(P-P)2]PF6 ...
- Search for ruthenium (II) complexes, with chemotherapeutic properties: evaluation of possible sinergistic effects and possible action mechanism, AP.R
Abstract
In this work we intend to synthesize complexes of general formula: [Ru(N-S)(bipy)(P-P)]PF6, [Ru(N-S)2(PPh3)2], [Ru(N-S)(fen)(P-P)]PF6 e [Ru(N-S)2(P-P)]; where (N-S = 2-mercaptotiozoline, 4,6-diamino-2-mercaptopirimidine, 2-mercaptoimadozol, 2-mercapto-1-metilimidazol, 6-mercaptopiridine-3-carboxílic acid; P-P = dppm = 1,1`-bis(diphenylphosphine)methane, dppe = 1,2-bis(diphenylphosphin...
- Study of apoptosis gene expression, celular cyclic, DNA repair and oxidative stress in cells of human lang carcinoma treated with complexes with general formula [Ru(AA)(dppb)(bipy)]PF6, AP.R
Abstract
Researches have demonstrated that ruthenium complexes present great specificity and selectivity by tumor cells than compounds based on platin. Two ruthenium complexes (NAMI and NAMI-A) completed clinic fase I, both with low level of side effects. Several ruthenium complexes have been synthesized and studied by our research group, in the Department of Chemistry/UFSCar, presenting signif...
(Only some records are available in English at this moment)
- Evaluation of anticancer properties of ruthenium(II)complexes containing lapachol and lawsone bioligands, BP.DR
Abstract
The present project centers on the synthesis of complexes of ruthenium (II) containing lapachol and lawsone bioligands, which may present the following formulas: [Ru(L-L)(bipy)(dppf)]PF6, [Ru(L-L)(bipy)(dppe)]PF6 and [Ru(L-L)(dppe)2]PF6, where L-L = lapachol and lawsone, bipy = 2,2'-bipyridine, dppf = 1,1'-bis(diphenylphosphino)ferrocene and dppe = 1,2'-bis (diphenylphosphino)ethane. Th...
- Structural modifications in biologically active Ru(II) complexes toward the design of new metallodrug candidates, BP.PD
Abstract
This research project is dedicated to obtaining and characterization of ruthenium(II) complexes containing ligands of biological interest, as new metallodrug candidates. In the first stage will be evaluated the best synthesis route, screening the feasibility of coordinating bioligands, which are derivatives of purines, pyrimidines, quinolines and derivatives of aciltioureas with rutheni...
- Ruthenium(II) complexes coordinated to dipyridophenazine and dipyridoquinoxaline ligands: cellular assays in tumor cell lines and study of the mechanism of action for their application in anticancer therapies, BP.PD
Abstract
This project aims at the synthesis of ruthenium(II) complexes coordinated to the ligands dppf (1,1'-diphenylphosphinoferrocene), dpq (dipyrido[3,2-f: 2',3'-h]quinoxaline), dppz (dipyrido[3,2-a:2 ', 3'-c]phenazine) dpqQX (dipyrido[3,2-f 2', 3'-h]quinoxaline[2,3-b]quinoxaline), dppzBTDZ (dipyrido[3,2-a: 2 ',3'-c]phenazine-10,11-(2,1,3-thiadiazole) and CO (carbonyl) and to study its physic...
(Only some records are available in English at this moment)
- Evaluation of the mechanism of action of ruthenium complexes containing bioactive natural products, BE.EP.DR
Abstract
Cancer is the second leading cause of death worldwide and, the forms of treatment of this disease has some limitations, by making necessary to develop new compounds that may be effective against this disease. The ruthenium complexes has been quite promising, showing metastatic properties. Therefore, in this project will be studied ruthenium complexes containing the lapachol as ligand, w...
- Effects of ruthenium compounds on the topoisomerase i enzyme as antitumoral mechanism, BE.EP.PD
Abstract
Cancer is predicted to be an increasingly important cause of morbidity and mortality in the next few decades. Because of therapeutic resistance and side effects, a wide range of studies are focused on the discovery of new drugs for cancer treatment. In view of this, transition metal-based compounds have been proposed as potential antitumor activity and antimestastatic behavior, in parti...
| 1 / 1 | Ongoing research grants |
| 29 / 13 | Completed research grants |
| 25 / 8 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 58 / 24 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 45 |
| Citations | 395 |
| Cit./Article | 8.8 |
| Data from Web of Science | |
PEREZ, H.; CORREA, R. S.; O'REILLY, B.; PLUTIN, A. M.; SILVA, C. C. P.; MASCARENHAS, Y. P.. Spectroscopic characterization and crystal structure of cis-Bis(N-(2-benzoyl)-N `,N `-diphenylthioureato-k O-2,S)nickel(II). JOURNAL OF STRUCTURAL CHEMISTRY, v. 53, n. 5, p. 921-926, SEP 2012. Web of Science Citations: 3. (09/08131-1)
CORREA, RODRIGO S.; BAROLLI, JOAO P.; RIBEIRO, LEANDRO; BATISTA, ALZIR A.; ELLENA, JAVIER; ANDRADE, MARCELO B.. Experimental and theoretical investigation of molecular structure and conformation of the 4-isopropylthioxanthone. Journal of Molecular Structure, v. 1000, n. 1-3, p. 155-161, AUG 10 2011. Web of Science Citations: 4. (09/08131-1)
BARBOSA, MARILIA I. F.; CORREA, RODRIGO S.; DE OLIVEIRA, KATIA MARA; RODRIGUES, CLAUDIA; ELLENA, JAVIER; NASCIMENTO, OTACIRO R.; ROCHA, VINICIUS P. C.; NONATO, FABIANA R.; MACEDO, TAIS S.; BARBOSA-FILHO, JOSE MARIA; et al. Antiparasitic activities of novel ruthenium/lapachol complexes. Journal of Inorganic Biochemistry, v. 136, p. 33-39, JUL 2014. Web of Science Citations: 30. (09/08131-1)
BARBOSA, MARILIA I. F.; CORREA, RODRIGO S.; POZZI, LUCAS V.; LOPES, ERICA DE O.; PAVAN, FERNANDO R.; LEITE, CLARICE Q. F.; ELLENA, JAVIER; MACHADO, SERGIO DE P.; VON POELHSITZ, GUSTAVO; BATISTA, ALZIR A.. Ruthenium(II) complexes with hydroxypyridinecarboxylates: Screening potential metallodrugs against Mycobacterium tuberculosis. Polyhedron, v. 85, p. 376-382, JAN 8 2015. Web of Science Citations: 17. (13/26559-4)
DE OLIVEIRA, TAMIRES D.; PLUTIN, ANA M.; LUNA-DULCEY, LIANY; CASTELLANO, EDUARDO E.; COMINETTI, MARCIA R.; BATISTA, ALZIR A.. Cytotoxicity of ruthenium-N,N-disubstituted-N `-acylthioureas complexes. Materials Science & Engineering C-Materials for Biological Applications, v. 115, OCT 2020. Web of Science Citations: 0. (18/05594-0, 18/19342-2)
CRIZOSTOMO KOCK, FLAVIO VINICIUS; COSTA, ANALU ROCHA; DE OLIVEIRA, KATIA MARA; BATISTA, ALZIR AZEVEDO; FERREIRA, ANTONIO GILBERTO; VENANCIO, TIAGO. A Supramolecular Interaction of a Ruthenium Complex With Calf-Thymus DNA: A Ligand Binding Approach by NMR Spectroscopy. FRONTIERS IN CHEMISTRY, v. 7, NOV 8 2019. Web of Science Citations: 0. (18/09145-5, 18/16040-5, 18/19342-2)
TAKARADA, JESSICA E.; GUEDES, ADRIANA P. M.; CORREA, RODRIGO S.; SILVEIRA-LACERDA, ELISANGELA DE P.; CASTELLI, SILVIA; IACOVELLI, FEDERICO; DEFLON, VICTOR MARCELO; BATISTA, ALZIR AZEVEDO; DESIDERI, ALESSANDRO. Ru/Fe bimetallic complexes: Synthesis, characterization, cytotoxicity and study of their interactions with DNA/HSA and human topoisomerase IB. Archives of Biochemistry and Biophysics, v. 636, p. 28-41, DEC 15 2017. Web of Science Citations: 8. (14/10516-7)
DE GRANDIS, RONE APARECIDO; DA SILVA DOS SANTOS, PATRICK WELLINGTON; DE OLIVEIRA, KATIA MARA; TOMAZELA MACHADO, ANA RITA; AISSA, ALEXANDRE FERRO; BATISTA, ALZIR AZEVEDO; GREGGI ANTUNES, LUSANIA MARIA; PAVAN, FERNANDO ROGERIO. Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells. BIOORGANIC CHEMISTRY, v. 85, p. 455-468, APR 2019. Web of Science Citations: 3. (16/16312-0, 16/22429-7, 18/00163-0)
VELOZO-SA, VIVIANNE S.; PEREIRA, LUCIANO R.; LIMA, ALINY P.; MELLO-ANDRADE, FRANCYELLI; REZENDE, MANUELA R. M.; GOVEIA, REBECA M.; PIRES, WANESSA C.; SILVA, MONIZE M.; OLIVEIRA, KATIA M.; FERREIRA, ANTONIO G.; et al. In vitro cytotoxicity and in vivo zebrafish toxicity evaluation of Ru(ii)/2-mercaptopyrimidine complexes. DALTON TRANSACTIONS, v. 48, n. 18, p. 6026-6039, MAY 14 2019. Web of Science Citations: 1. (16/16312-0, 14/04147-9)
PEREIRA, FLAVIA DE C.; LIMA, BENEDICTO A. V.; DE LIMA, ALINY P.; PIRES, WANESSA C.; MONTEIRO, THALLITA; MAGALHAES, LORENA F.; COSTA, WANDERSON; GRAMINHA, ANGELICA E.; BATISTA, ALZIR A.; ELLENA, JAVIER; et al. Cis-[RuCl(BzCN)(N-N)(P-P)WF6 complexes: Synthesis and in vitro antitumor activity (BzCN = benzonitrile; N-N=2,2 `-bipyridine; 1,10-phenanthroline; P-P=1,4-bis(diphenylphosphino) butane, 1,2-bis(diphenylphosphino)ethane, or 1,1 `-(diphenylphosphino)ferrocene). Journal of Inorganic Biochemistry, v. 149, p. 91-101, AUG 2015. Web of Science Citations: 14. (12/06013-4)
BECCENERI, AMANDA B.; FUZER, ANGELINA M.; PLUTIN, ANA M.; BATISTA, ALZIR A.; LELIEVRE, SOPHIE A.; COMINETTI, MARCIA R.. Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by the trans-[Ru(PPh3)(2)(N,N-dimethyl-N-thiophenyl-thioureato-k(2)O,S)(bipy) ]PF6 complex. INORGANIC CHEMISTRY FRONTIERS, v. 7, n. 16, p. 2909-2919, AUG 21 2020. Web of Science Citations: 0. (15/24940-8, 17/01287-2, 17/20055-5, 18/19342-2, 13/07600-3, 14/25121-8)
PIRES, WANESSA CARVALHO; VIEIRA LIMA, BENEDICTO AUGUSTO; PEREIRA, FLAVIA DE CASTRO; LIMA, ALINY PEREIRA; MELLO-ANDRADE, FRANCYELLI; SILVA, HUGO DELLEON; DA SILVA, MONIZE MARTINS; COLINA-VEGAS, LEGNA; ELLENA, JAVIER; BATISTA, ALZIR A.; et al. Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation. Molecular and Cellular Biochemistry, v. 438, n. 1-2, p. 199-217, JAN 2018. Web of Science Citations: 2. (14/10516-7)
DA SILVA, MONIZE M.; DE CAMARGO, MARIANA S.; CORREA, RODRIGO S.; CASTELLI, SILVIA; DE GRANDIS, RONE A.; TAKARADA, JESSICA E.; VARANDA, ELIANA A.; CASTELLANO, EDUARDO E.; DEFLON, VICTOR M.; COMINETTI, MARCIA R.; et al. Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding. DALTON TRANSACTIONS, v. 48, n. 39, p. 14885-14897, OCT 21 2019. Web of Science Citations: 0. (16/16312-0)
OLIVEIRA, KATIA M.; CORREA, RODRIGO S.; BARBOSA, MARILIA I. F.; ELLENA, JAVIER; COMINETTI, MARCIA R.; BATISTA, ALZIR A.. Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity Of lapachol. Polyhedron, v. 130, p. 108-114, JUL 7 2017. Web of Science Citations: 12. (14/04147-9)
MACEDO, TAIS S.; VILLARREAL, WILMER; COUTO, CAMILA C.; MOREIRA, DIOGO R. M.; NAVARRO, MARIBEL; MACHADO, MARTA; PRUDENCIO, MIGUEL; BATISTA, ALZIR A.; SOARES, MILENA B. P.. Platinum(II)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function. METALLOMICS, v. 9, n. 11, p. 1548-1561, NOV 1 2017. Web of Science Citations: 4. (14/10516-7)
DOS SANTOS, EDJANE R.; GRAMINHA, ANGELICA E.; SCHULTZ, MARIO S.; CORREIA, ISABEL; SELISTRE-DE-ARAUJO, HELOISA S.; CORREA, RODRIGO S.; ELLENA, JAVIER; LACERDA, ELISANGELA DE PAULA S.; PESSOA, JOAO COSTA; BATISTA, ALZIR A.. Cytotoxic activity and structural features of Ru(II)/phosphine/amino acid complexes. Journal of Inorganic Biochemistry, v. 182, p. 48-60, MAY 2018. Web of Science Citations: 6. (12/06013-4)
LIMA, ALINY PEREIRA; PEREIRA, FLAVIA CASTRO; PINHEIRO ALMEIDA, MARCIO AURELIO; SANTOS MELLO, FRANCYELLI MARIANA; PIRES, WANESSA CARVALHO; PINTO, THALLITA MONTEIRO; DELELLA, FLAVIA KARINA; FELISBINO, SERGIO LUIS; MORENO, VIRTUDES; BATISTA, ALZIR AZEVEDO; et al. Cytoxicity and Apoptotic Mechanism of Ruthenium(II) Amino Acid Complexes in Sarcoma-180 Tumor Cells. PLoS One, v. 9, n. 10, OCT 17 2014. Web of Science Citations: 24. (12/06013-4)
BENEDICTO A. V. LIMA; RODRIGO S. CORRÊA; ANGELICA E. GRAMINHA; ALEKSEY KUZNETSOV; JAVIER ELLENA; FERNANDO R. PAVAN; CLARICE Q. F. LEITE; ALZIR A. BATISTA. Anti-Mycobacterium tuberculosis and Cytotoxicity Activities of Ruthenium(II)/ Bipyridine/Diphosphine/Pyrimidine-2-thiolate Complexes: The Role of the Non- Coordinated N-Atom. Journal of the Brazilian Chemical Society, v. 27, n. 1, p. -, Jan. 2016. (13/26559-4, 12/06013-4)
ANA M. PLUTÍN; ANISLAY ALVAREZ; RAÚL MOCELO; RAÚL RAMOS; OSMAR C. SÁNCHEZ; EDUARDO E. CASTELLANO; MONIZE M. DA SILVA; WILMER VILLARREAL; LEGNA COLINA-VEGAS; FERNANDO R. PAVAN; et al. Structure/Activity of PtII/N,N-Disubstituted-N'-acylthiourea Complexes: Anti-Tumor and Anti-Mycobacterium tuberculosis Activities. Journal of the Brazilian Chemical Society, v. 29, n. 6, p. -, Jun. 2018. (14/10516-7)
MELLO-ANDRADE, FRANCYELLI; CARDOSO, CLEVER GOMES; RIBEIRO E SILVA, CAROLINA; CHEN-CHEN, LEE; DE MELO-REIS, PAULO ROBERTO; DE LIMA, ALINY PEREIRA; OLIVEIRA, RHAUL; MACHADO FERRAZ, IRVIN BRYAN; GRISOLIA, CESAR KOPPE; PINHEIRO ALMEIDA, MARCIO AURELIO; et al. Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos. BIOMEDICINE & PHARMACOTHERAPY, v. 107, p. 1082-1092, NOV 2018. Web of Science Citations: 5. (14/10516-7)
PLUTIN, ANA M.; ALVAREZ, ANISLAY; MOCELO, RAUL; RAMOS, RAUL; SANCHEZ, OSMAR C.; CASTELLANO, EDUARDO E.; DA SILVA, MONIZE M.; VILLARREAL, WILMER; COLINA-VEGAS, LEGNA; PAVAN, FERNANDO R.; et al. Structure/Activity of Pt-II/& IT;N & IT;,& IT;N & IT;-Disubstituted-& IT;N & IT;'-acylthiourea Complexes: Anti-Tumor and Anti-& IT;Mycobacterium tuberculosis & IT; Activities. Journal of the Brazilian Chemical Society, v. 29, n. 6, p. 1256-1267, JUN 2018. Web of Science Citations: 1. (14/10516-7)
LEITE, TAISE H. O.; GRAWE, GREGORY; HONORATO, JOAO; CUNHA, BEATRIZ N.; NASCIMENTO, OTACIRO R.; DE VARGAS, PAMELA S.; DONATONI, CAROLINA; OLIYEIRA, KLEBER T.; LOPES, JEFFERSON M. S.; BARBOSA NETO, NEWTON M.; et al. Remarkable Electronic Effect on the meso-Tetra(thienyl)porphyrins. Inorganic Chemistry, v. 58, n. 2, p. 1030-1039, JAN 21 2019. Web of Science Citations: 2. (15/21110-4, 18/00106-7, 16/16312-0)
BARBOSA, M. I. F.; CORREA, R. S.; BASTOS, T. M.; POZZI, L. V.; MOREIRA, D. R. M.; ELLENA, J.; DORIGUETTO, A. C.; SILVEIRA, R. G.; OLIVEIRA, C. R.; KUZNETSOV, A. E.; et al. Structural isomerism of Ru(II)-carbonyl complexes: synthesis, characterization and their antitrypanosomal activities. NEW JOURNAL OF CHEMISTRY, v. 41, n. 11, p. 4468-4477, JUN 7 2017. Web of Science Citations: 6. (14/10516-7)
OLIVEIRA, KATIA M.; LIANY, LUNA-DULCEY; CORREA, RODRIGO S.; DEFLON, VICTOR M.; COMINETTI, MARCIA R.; BATISTA, ALZIR A.. Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis. Journal of Inorganic Biochemistry, v. 176, p. 66-76, NOV 2017. Web of Science Citations: 18. (14/04147-9)
PEREZ, H.; CORREA, R. S.; O'REILLY, B.; PLUTIN, A. M.; SILVA, C. C. P.; MASCARENHAS, Y. P.. Spectroscopic characterization and crystal structure of cis-Bis(N-(2-benzoyl)-N `,N `-diphenylthioureato-k O-2,S)nickel(II). JOURNAL OF STRUCTURAL CHEMISTRY, v. 53, n. 5, p. 921-926, SEP 2012. Web of Science Citations: 3. (09/08131-1)
CORREA, RODRIGO S.; BAROLLI, JOAO P.; RIBEIRO, LEANDRO; BATISTA, ALZIR A.; ELLENA, JAVIER; ANDRADE, MARCELO B.. Experimental and theoretical investigation of molecular structure and conformation of the 4-isopropylthioxanthone. Journal of Molecular Structure, v. 1000, n. 1-3, p. 155-161, AUG 10 2011. Web of Science Citations: 4. (09/08131-1)
BARBOSA, MARILIA I. F.; CORREA, RODRIGO S.; DE OLIVEIRA, KATIA MARA; RODRIGUES, CLAUDIA; ELLENA, JAVIER; NASCIMENTO, OTACIRO R.; ROCHA, VINICIUS P. C.; NONATO, FABIANA R.; MACEDO, TAIS S.; BARBOSA-FILHO, JOSE MARIA; et al. Antiparasitic activities of novel ruthenium/lapachol complexes. Journal of Inorganic Biochemistry, v. 136, p. 33-39, JUL 2014. Web of Science Citations: 30. (09/08131-1)
BARBOSA, MARILIA I. F.; CORREA, RODRIGO S.; POZZI, LUCAS V.; LOPES, ERICA DE O.; PAVAN, FERNANDO R.; LEITE, CLARICE Q. F.; ELLENA, JAVIER; MACHADO, SERGIO DE P.; VON POELHSITZ, GUSTAVO; BATISTA, ALZIR A.. Ruthenium(II) complexes with hydroxypyridinecarboxylates: Screening potential metallodrugs against Mycobacterium tuberculosis. Polyhedron, v. 85, p. 376-382, JAN 8 2015. Web of Science Citations: 17. (13/26559-4)
DE OLIVEIRA, TAMIRES D.; PLUTIN, ANA M.; LUNA-DULCEY, LIANY; CASTELLANO, EDUARDO E.; COMINETTI, MARCIA R.; BATISTA, ALZIR A.. Cytotoxicity of ruthenium-N,N-disubstituted-N `-acylthioureas complexes. Materials Science & Engineering C-Materials for Biological Applications, v. 115, OCT 2020. Web of Science Citations: 0. (18/05594-0, 18/19342-2)
CRIZOSTOMO KOCK, FLAVIO VINICIUS; COSTA, ANALU ROCHA; DE OLIVEIRA, KATIA MARA; BATISTA, ALZIR AZEVEDO; FERREIRA, ANTONIO GILBERTO; VENANCIO, TIAGO. A Supramolecular Interaction of a Ruthenium Complex With Calf-Thymus DNA: A Ligand Binding Approach by NMR Spectroscopy. FRONTIERS IN CHEMISTRY, v. 7, NOV 8 2019. Web of Science Citations: 0. (18/09145-5, 18/16040-5, 18/19342-2)
BENEDICTO A. V. LIMA; RODRIGO S. CORRÊA; ANGELICA E. GRAMINHA; ALEKSEY KUZNETSOV; JAVIER ELLENA; FERNANDO R. PAVAN; CLARICE Q. F. LEITE; ALZIR A. BATISTA. Anti-Mycobacterium tuberculosis and Cytotoxicity Activities of Ruthenium(II)/ Bipyridine/Diphosphine/Pyrimidine-2-thiolate Complexes: The Role of the Non- Coordinated N-Atom. Journal of the Brazilian Chemical Society, v. 27, n. 1, p. -, Jan. 2016. (13/26559-4, 12/06013-4)
CORREA, RODRIGO S.; DE OLIVEIRA, KATIA M.; DELOLO, FABIO G.; ALVAREZ, ANISLAY; MOCELO, RAUL; PLUTIN, ANA M.; COMINETTI, MARCIA R.; CASTELLANO, EDUARDO E.; BATISTA, ALZIR A.. Ru(II)-based complexes with N-(acyl)-N `,N `-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells. Journal of Inorganic Biochemistry, v. 150, p. 63-71, SEP 2015. Web of Science Citations: 44. (14/04147-9, 13/26559-4)
RODRIGUES, M. V. N.; CORREA, R. S.; VANZOLINI, K. L.; SANTOS, D. S.; BATISTA, A. A.; CASS, Q. B.. Characterization and screening of tight binding inhibitors of xanthine oxidase: an on-flow assay. RSC ADVANCES, v. 5, n. 47, p. 37533-37538, 2015. Web of Science Citations: 6. (13/01710-1, 09/08131-1, 13/26559-4)
ALMEIDA, MARCIO A. P.; DO NASCIMENTO, FABIO B.; GRAMINHA, ANGELICA E.; FERREIRA, ANTONIO G.; ELLENA, JAVIER; MELLO, FRANCYELLI M. DOS S.; DE LIMA, ALINY P.; SILVEIRA-LACERDA, ELISANGELA DE P.; BATISTA, ALZIR A.. Structural features and cytotoxic activities of [Ru(AA-H)(dppb)(bipy)]PF6 complexes. Polyhedron, v. 81, p. 735-742, OCT 15 2014. Web of Science Citations: 10. (12/06013-4)
MUNDIM GUEDES, ADRIANA PEREIRA; MELLO-ANDRADE, FRANCYELLI; PIRES, WANESSA CARVALHO; MONTES DE SOUSA, MARIA ALICE; FAUSTINO DA SILVA, PAULA FRANCINETE; DE CAMARGO, MARIANA S.; GEMEINER, HENDRYK; AMAURI, MENEGARIO A.; CARDOSO, CLEVER GOMES; DE MELO REIS, PAULO ROBERTO; et al. Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets. METALLOMICS, v. 12, n. 4, p. 547-561, APR 1 2020. Web of Science Citations: 0. (16/16312-0)
PIRES, WANESSA CARVALHO; VIEIRA LIMA, BENEDICTO AUGUSTO; PEREIRA, FLAVIA DE CASTRO; LIMA, ALINY PEREIRA; MELLO-ANDRADE, FRANCYELLI; SILVA, HUGO DELLEON; DA SILVA, MONIZE MARTINS; COLINA-VEGAS, LEGNA; ELLENA, JAVIER; BATISTA, ALZIR A.; et al. Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation. Molecular and Cellular Biochemistry, v. 438, n. 1-2, p. 199-217, JAN 2018. Web of Science Citations: 2. (14/10516-7)
OLIVEIRA, KATIA M.; LIANY, LUNA-DULCEY; CORREA, RODRIGO S.; DEFLON, VICTOR M.; COMINETTI, MARCIA R.; BATISTA, ALZIR A.. Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis. Journal of Inorganic Biochemistry, v. 176, p. 66-76, NOV 2017. Web of Science Citations: 18. (14/04147-9)
OLIVEIRA, KATIA M.; CORREA, RODRIGO S.; BARBOSA, MARILIA I. F.; ELLENA, JAVIER; COMINETTI, MARCIA R.; BATISTA, ALZIR A.. Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity Of lapachol. Polyhedron, v. 130, p. 108-114, JUL 7 2017. Web of Science Citations: 12. (14/04147-9)
MACEDO, TAIS S.; VILLARREAL, WILMER; COUTO, CAMILA C.; MOREIRA, DIOGO R. M.; NAVARRO, MARIBEL; MACHADO, MARTA; PRUDENCIO, MIGUEL; BATISTA, ALZIR A.; SOARES, MILENA B. P.. Platinum(II)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function. METALLOMICS, v. 9, n. 11, p. 1548-1561, NOV 1 2017. Web of Science Citations: 4. (14/10516-7)
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