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Rafael Victorio Carvalho Guido

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Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Associate professor at the Physics Institute of São Carlos (IFSC) of the University of São Paulo (USP). He received his PhD in biomolecular physics from the University of São Paulo and the University of Marburg in 2008, and completed two years of postdoctoral work in medicinal chemistry and structural biology at the University of São Paulo. He is a specialist in structure-based drug design and in the integration of computational and experimental methods. His research is focused on the structural elucidation of relevant molecular targets and the application of this knowledge toward the discovery and development of new drugs and agrochemicals for human and plant diseases. He is the coordinator of a Young Research Grant from Serrapilheira Institute, whose scientific approach consists of the use of a variety of advanced methods for agrochemical and drug design. He has published 69 scientific papers and 6 book chapters. He is associated investigator of the Center for Research and Innovation in Biodiversity and Drugs (CIBFar-CEPID-FAPESP). He was the Chair (2016-2018) and Vice-Chair (2014-2016) of the Medicinal Chemistry Division of the Brazilian Chemical Society. Currently, he was an Affiliated Member of The World Academy of Sciences (TWAS) (2105-2020) and an Young Scientist of the World Economic Forum (WEF). (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated February 15, 2020
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (17)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

SOUZA-MOREIRA, TATIANA M.; ALVES, THAS B.; PINHEIRO, KARINA A.; FELIPPE, LIDIANE G.; DE LIMA, GUSTAVO M. A.; WATANABE, TATIANA F.; BARBOSA, CRISTINA C.; SANTOS, VANIA A. F. F. M.; LOPES, NORBERTO P.; VALENTINI, SANDRO R.; et al. Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 9. (12/21005-8, 14/03819-3, 13/07600-3, 11/10379-1, 12/09584-2, 13/15306-8)

CORNELIO, VIVIAN E.; MALUF, FERNANDO V.; FERNANDES, JOAO B.; DA SILVA, MARIA FATIMA G. F.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; VIEIRA, PAULO C.. Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation. Journal of the Brazilian Chemical Society, v. 28, n. 3, SI, p. 512-519, . Web of Science Citations: 7. (09/17538-8, 13/07600-3)

FAGUNDEZ, CATHERINE; SELLANES, DIVER; PENA, STELLA; SCARONE, LAURA; AGUIAR, ANNA C. C.; DE SOUZA, JULIANA O.; GUIDO, RAFAEL V. C.; STEWART, LINDSAY; YARDLEY, VANESSA; OTTILIE, SABINE; et al. Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents. ACS Medicinal Chemistry Letters, v. 10, n. 1, p. 137-141, . Web of Science Citations: 1. (13/07600-3)

MALUF, FERNANDO V.; ANDRICOPULO, ADRIANO D.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.. A pharmacophore-based virtual screening approach for the discovery of Trypanosoma cruzi GAPDH inhibitors. Future Medicinal Chemistry, v. 5, n. 17, p. 2019-2035, . Web of Science Citations: 17. (13/07600-3)

BUENO, RENATA; DAWSON, ALICE; HUNTER, WILLIAM N.. An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 75, n. 3, p. 148-152, . Web of Science Citations: 0. (16/16038-5)

GODOY, ANDRE S.; LIMA, GUSTAVO M. A.; OLIVEIRA, KETLLYN I. Z.; TORRES, NAIARA U.; MALUF, FERNANDO V.; GUIDO, RAFAEL V. C.; OLIVA, GLAUCIUS. Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. NATURE COMMUNICATIONS, v. 8, . Web of Science Citations: 42. (16/19712-9, 13/07600-3, 15/16811-3, 16/17153-2)

MACIEL, LARISSA G.; OLIVEIRA, ANDREW A.; ROMAO, TATIANY P.; LEAL, LAYLLA L. L.; GUIDO, RAFAEL V. C.; SILVA-FILHA, MARIA HELENA N. L.; DOS ANJOS, JANAINA V.; SOARES, THEREZA A.. Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti. Bioorganic & Medicinal Chemistry, v. 28, n. 2, . Web of Science Citations: 0. (13/07600-3)

DE SOUZA, GUILHERME EDUARDO; BUENO, RENATA VIEIRA; DE SOUZA, JULIANA OLIVEIRA; ZANINI, CAMILA LIMA; CRUZ, FABIO CARDOSO; OLIVA, GLAUCIUS; CARVALHO GUIDO, RAFAEL VICTORIO; CAMPOS AGUIAR, ANNA CAROLINE. Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies. Malaria Journal, v. 18, n. 1, . Web of Science Citations: 0. (16/09772-4, 13/07600-3, 15/18192-9)

MARTELLI, LORENA S. R.; VIEIRA, LUCAS C. C.; PAIXAO, MARCIO W.; ZUKERMAN-SCHPECTOR, JULIO; DE SOUZA, JULIANA O.; AGUIAR, ANNA CAROLINE C.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; CORREA, ARLENE G.. Organocatalytic asymmetric vinylogous 1,4-addition of alpha,alpha-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity. Tetrahedron, v. 75, n. 25, p. 3530-3542, . Web of Science Citations: 0. (14/50249-8, 13/07600-3, 17/26679-0)

AGUIAR, ANNA CAROLINE; DE SOUSA, LORENA R. F.; GARCIA, CELIA R. S.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.. New Molecular Targets and Strategies for Antimalarial Discovery. Current Medicinal Chemistry, v. 26, n. 23, p. 4380-4402, . Web of Science Citations: 6. (11/51295-5, 13/07600-3)

CARBALLEIRA, NESTOR M.; BWALYA, ANGELA GONO; ITOE, MAURICE AYAMBA; ANDRICOPULO, ADRIANO D.; CORDERO-MALDONADO, MARIA LORENA; KAISER, MARCEL; MOTA, MARIA M.; CRAWFORD, ALEXANDER D.; GUIDO, RAFAEL V. C.; TASDEMIR, DENIZ. 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & Medicinal Chemistry Letters, v. 24, n. 17, p. 4151-4157, . Web of Science Citations: 5. (13/07600-3)

CHUNG, MAN-CHIN; GUIDO, RAFAEL VICTÓRIO CARVALHO; MARTINELLI, TATIANE FAVARATO; GONÇALVES, MARINEI FERREIRA; POLLI, MICHELLE CARNEIRO; BOTELHO, KATIA CIRLENE ALVES; VARANDA, ELIANA APARECIDA; COLLI, WALTER; MIRANDA, M. TERÊSA M.; FERREIRA, ELIZABETH IGNE. Synthesis and in vitro evaluation of potential antichagasic hydroxymethyinitrofurazone (NFOH-121): A new nitrofurazone prodrug. Bioorganic & Medicinal Chemistry, v. 11, n. 22, p. 4779-4783, . (95/04562-3, 01/01192-3)

PARRA, LIZBETH L. L.; BERTONHA, ARIANE F.; SEVERO, IVAN R. M.; AGUIAR, ANNA C. C.; DE SOUZA, GUILHERME E.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; GRAZZIA, NATHALIA; COSTA, TABATA R.; MIGUEL, DANILO C.; et al. Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis. Journal of Natural Products, v. 81, n. 1, p. 188-202, . Web of Science Citations: 3. (13/50228-8, 15/24595-9, 14/21129-4, 13/07600-3)

ALVES, EDUARDO; MALUF, FERNANDO V.; BUENO, VANIA B.; GUIDO, RAFAEL V. C.; OLIVA, GLAUCIUS; SINGH, MANEESH; SCARPELLI, PEDRO; COSTA, FAHYME; SARTORELLO, ROBSON; CATALANI, LUIZ H.; et al. Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2 alpha) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 6. (11/51295-5, 13/07600-3, 11/21442-6)

FRANCESCHINI SARRIA, ANDRE LUCIO; SILVA, TAYNARA LOPES; DE OLIVEIRA, JULIANA MAGALHAES; RODRIGUES DE OLIVEIRA, MILENE APARECIDA; FERNANDES, JOAO BATISTA; DAS GRACAS FERNANDES DA SILVA, MARIA FATIMA; VIEIRA, PAULO CEZAR; VENANCIO, TIAGO; ALVES FILHO, ELENILSON DE GODOY; BATISTA, JR., JOAO M.; et al. Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors. Phytochemistry, v. 154, p. 31-38, . Web of Science Citations: 3. (15/07089-2, 13/07600-3, 06/58043-3, 09/01847-1, 14/25222-9)

DE GODOY, ANDRE SCHUTZER; FERNANDES, RAFAELA SACHETTO; CAMPOS AGUIAR, ANNA CAROLINE; BUENO, RENATA VIEIRA; DE MORAES ROSO MESQUITA, NATHALYA CRISTINA; CARVALHO GUIDO, RAFAEL VICTORIO; OLIVA, GLAUCIUS. Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases. CURRENT OPINION IN STRUCTURAL BIOLOGY, v. 59, p. 65-72, . Web of Science Citations: 0. (16/19712-9, 18/05130-3, 13/07600-3, 15/18192-9)

CAMPOS AGUIAR, ANNA CAROLINE; PANCIERA, MICHELE; SIMAO DOS SANTOS, ERIC FRANCISCO; SINGH, MANEESH KUMAR; GARCIA, MARIANA LOPES; DE SOUZA, GUILHERME EDUARDO; NAKABASHI, MYNA; COSTA, JOSE LUIZ; GARCIA, CELIA R. S.; OLIVA, GLAUCIUS; et al. Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity. Journal of Medicinal Chemistry, v. 61, n. 13, p. 5547-5568, . Web of Science Citations: 7. (11/51295-5, 15/18192-9, 13/07600-3, 13/25613-5, 14/25770-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BUENO, Renata Vieira. Estudos estruturais e funcionais da enzima N5, N10 - metilenotetrahidrofolato-desidrogenase-ciclohidrolase de Xanthomonas albilineans aplicados à descoberta de candidatos a inibidores para o tratamento da escaldadura das folhas. 2018. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

SOUZA, Guilherme Eduardo de. Descoberta de derivados de hidrazinobenzimidazol como inibidores de Plasmodium falciparum: Síntese orgânica, atividade biológica e relação estrutura-atividade. 2018. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

GARCIA, Mariana Lopes. Estudos computacionais da enzima N-miristoiltransferase de Plasmodium falciparum e seus inibidores como candidatos a agentes antimaláricos. 2017. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

GUIDO, Rafael Victorio Carvalho. Planejamento de inibidores da enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi: biologia estrutural e química medicinal. 2008. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

MALUF, Fernando Vasconcelos. Estudos estruturais e de química medicinal aplicados às enzimas da via glicolítica de protozoários: enolase de Plasmodium falciparum e gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi. 2015. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

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