bachelor's at Medicina from Faculdade de Ciências da Saúde da Universidade de Brasília (1986), master's at Medicina from Faculdade de Medicina de Ribeirão Preto-USP (1994) and doctorate at Medicina from Faculdade de Medicina de Ribeirão Preto-USP (1999). Has experience in Medicine, focusing on Medicine, acting on the following subjects: insuficiência cardíaca, cintilografia de perfusão miocárdica, isquemia miocárdica, cardiopatia chagásica crônica and reserva contrátil. (Source: Lattes Curriculum)
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This thematic proposal encompasses 13 investigations to be carried out by a group of 26 clinical, basic research scientists and post-graduate students, from 8 academic institutions, on the pathogenesis, pathophysiology and therapeutic aspects related to the chronic Chagas cardiomyopathy (CCC). The investigations will be performed in humans and in Syrian hamsters experimentally infected wi…
Rational foundation: Several physiopathogenetic aspects of the Chronic Chagas Cardiomyopathy (CCC) are still unclear, mainly the mechanisms leading to the late development of the myocardial tissue damage, arising 2 to 3 decades after the acute phase. Beyond the 2 main mechanisms, i.e. persistent parasitism and exacerbated inflammatory aggression, myocardial ischemia due to microvascular d…
A study recently conducted in our research group showed that 4 months of aerobic exercise training promoted significant improvement of myocardial perfusion and chest pain in patients with coronary microvascular dysfunction. These original results suggested that.aerobic exercise training could be a effective therapeutic intervention in patients with coronary microvascular dysfunction. The …
The pathophysiology of the chronic Chagas cardiomiopathy (CCC) presents several unknown aspects. The main point is the recognition of the mechanisms involved in the genesis of the myocardial damage appearing only 2 to 3 decades after the acute phase of the disease. The central role of a low-grade relentless parasitism and the auto-immune aggression is clearly defined. However, several cli…
(Only some records are available in English at this moment)
Several pathophysiological aspects of Chronic Chagasic Cardiomyopathy (CCC) still need more elucidation, especially the mechanisms that determine the appearance of chronic myocardial injury in the late phase, 2 to 3 decades after the acute phase. In addition to the persistence of the parasite in cardiac tissue and the exacerbated inflammatory response associated with aspects of autoimmuni…
Several pathophysiological aspects of chronic chagasic cardiomyopathy (CCC) still need more elucidation, especially the mechanisms that determine the appearance of chronic myocardial injury in the late phase, 2 to 3 decades after the acute phase. In addition to the persistence of the parasite in cardiac tissue and the exacerbated inflammatory response associated with aspects of autoimmuni…
Several pathophysiological aspects of chronic Chagas cardiomyopathy (CCC) still need elucidation, especially the mechanisms that determine the development of chronic myocardial injury only in late stage 2-3 decades after the acute phase. Besides the persistence of the parasite in the cardiac tissue and exacerbate inflammatory response by autoimmunity, experimental and clinical evidences s…
(Only some records are available in English at this moment)
Several pathophysiological aspects of chronic Chagas cardiomyopathy (CCC) still need elucidation, especially the mechanisms that determine the development of chronic myocardial injury only in late stage 2-3 decades after the acute phase. Besides the persistence of the parasite in the cardiac tissue and exacerbate inflammatory response by autoimmunity, experimental and clinical evidences s…
| 1 / 1 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 10 / 5 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 22 / 14 | All research grants and scholarships |
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CV Lattes
ORCID