CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Wilma De Grava Kempinas is a biologist graduated from USP, where she also developed a postgraduate course in Morphology - Cell Biology at the Ribeirão Preto Medical School. The Post-Doctorate was completed in 1998, in the field of Reproductive Toxicology and Epididymal Biology, by the United States Environmental Protection Agency (US EPA). She worked as a Professor at UNESP from 1988 to 2019 (Full Professor in Embryology since 2011). Since retirement, she has had a formal relationship with UNESP as a Senior Professor at the Institute of Biosciences of Botucatu (IBB), coordinating the Laboratory of Biology and Toxicology of Reproduction and Development (Reprotox). She advises the Postgraduate Program in General and Applied Biology at IBB. She is a member of the Society of Toxicology (SOT). In addition to acting as Associate Editor of the international journals "Reproductive Toxicology" and "Drug and Chemical Toxicology", she belongs to the Editorial Board of important journals in the fields of Toxicology and Reproduction: Journal of Toxicology and Environmental Health, Toxicology, Journal of Applied Toxicology, Current Research in Toxicology, Birth Defects Research, and Animal Reproduction. She maintains scientific exchanges with researchers in Brazil, Argentina, USA and Canada. The work carried out by the team she coordinates aims to investigate normal morphofunctional aspects and the effects of potentially toxic agents on the male and female reproductive systems, fertility, prenatal and postnatal development, using especially rodents as an experimental model. In an entrepreneurial approach, with the objective of collaborating with the social and environmental well-being, the generation of jobs and the sustainable economic development of the country, it develops research for the population control of animals, with the filing of a patent application at the INPI. The list of abstracts presented at scientific events and the journals for which ad hoc opinions are issued is not updated in CV Lattes. (Source: Lattes Curriculum)
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Surgical castration is the method used in the population control of domestic, experimental and production animals. However, it is not indicated in the control of synanthropic animals. Thus, chemical agents that can promote infertility, are being studied and developed in order to fill this gap. Ethane dimethanesulfonate (EDS) is an alkylating ester that acts directly on Leydig cells promot…
(Only some records are available in English at this moment)
The overpopulation of synanthropic and stray animals creates a chaotic scenario for the application of effective population control strategies. These animals, including rodents, circulate freely in urban centers, reproduce, in addition to contributing to the transmission of zoonotic pathogens and causing accidents. Surgical contraceptive methods in these cases are unfeasible, leading to p…
Surgical castration is the method used in the population control of domestic, experimental and production animals. However, it is not indicated in the control of synanthropic animals. Thus, chemical agents that can promote infertility, are being studied and developed in order to fill this gap. Ethane dimethanesulfonate (EDS) is an alkylating ester that acts directly on Leydig cells promot…
Corticotherapy has been widely used in obstetric practice in pregnant women at risk of preterm birth, promoting fetal lung maturation, consequently, decreasing the incidence of respiratory distress syndrome, mortality and neonatal morbidity. Studies conducted in our Laboratory have demonstrated that prenatal exposure to betamethasone promoted changes in the histophysiological aspect of th…
(Only some records are available in English at this moment)
Ethane dimethanesulfonate (EDS) is a molecule with known selective cytotoxicity on adult Leydig cells after gavage, intraperitoneal, and intratesticular injections, which leads to male androgen deprivation and infertility. After EDS exposure in adult male rats, the adult Leydig cells repopulate the testis from the stem Leydig cell pool and start to produce androgen hormones again. In vitr…
Obesity is a public health problem that is growing worldwide in recent years. This disease, characterized by presenting cardiovascular risk factors such as dyslipidemia, is intrinsically associated with several morbidities such as diabetes, metabolic syndrome and cancer. Several drugs have been used in the treatment of obese patients, such as statins and bupropion. Statins have been highl…
Endocrine Disrupting Chemicals (EDCs) are substances that may interfere with the homeostasis of natural hormones in the body. Among several classes of EDCs, important examples of these compounds are parabens and phthalates, both widely used in a variety of products and frequently found as contaminant in human tissues. Parabens are preservatives widely used in pharmaceutical products, food…
(Only some records are available in English at this moment)
| 22 / 13 | Completed research grants |
| 65 / 30 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 91 / 47 | All research grants and scholarships |
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