CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Medicina from Universidade Federal de São Paulo (1988), master's at Hematology from Universidade Federal de São Paulo (1993) and doctorate at Hematology from Universidade Federal de São Paulo (1995). Has experience in Medicine, focusing on Medicine, acting on the following subjects: metabolism and Ageing. (Source: Lattes Curriculum)
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Sarcopenia and neurocognitive disorder, including dementia and mild cognitive impairment (MCI), are common conditions among the elderly, with a high potential to cause disability, and loss of independence and autonomy. Although multifactorial, these conditions share pathophysiological factors that suggest a connection between them. The search for biomarkers that confirm this link and iden…
Bone marrow neoplasias are aggressive disorders with low healing potential. As the incidence of cancer increases with age, a growing number of older individuals are receiving therapy for cancer and frequently in intensive modalities. As these older patients tend to present comorbidities, treatment decisions can often become difficult due to their fragile physical state which may affect th…
The main objective of this proposal is the development of studies that aggressively seek possible biomarkers and therapeutic targets four frequent B-cell lymphoproliferative disorders: multiple myeloma (MM), diffuse large B-cell lymphomas (DLBCL), mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). The subproject 1 aims at identifying mutations JAK/STAT pathway genes and po…
The aims of this study are: 1) to correlate gene expression profiles with clinical staging at diagnosis, cytogenetic abnormalities, cell surface antigens and histology of bone marrow in MM patients; 2) to identify changes in gene expression profiles in MM patients induced by treatment with thalidomide; 3) to correlate eventual heterogeneity of gene expression at diagnosis with therapeutic…
Chronic myeloid leukemia is a myeloproliferative neoplasia which affects middle-aged people. Its physiopathology is related to the existence of a reciprocal translocation between chromosomes 9 and 22, creating a marker chromosome, the Philadelphia (Ph1), and the oncogene BCR-ABL. This gene has tyrosine kinase activity and the treatment is made with inhibitors of the enzime (TKi). Although…
Multiple myeloma (MM) is a malignant hematologic cancer characterized by infiltration of plasma tumor cells into the bone marrow (BM), synthesis and secretion of clonal immunoglobulins and tissue damage such as bone lesions, hypercalcemia, anemia and renal failure. Despite progress in treatment, the MM remains incurable due to high rate of relapse. The presence of cancer stem cells (CSCs)…
Multiple Myeloma (MM) is the second most prevalent hematological neoplasia in the United States. It is characterized by infiltration of tumor plasma cells in the bone marrow, synthesis of monoclonal immunoglobulins and tissue damages, such as osteolytic lesions. Despite of the progress achieved in the last decades regarding the frontline treatment for MM, this malignant neoplasia remains …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 8 / 3 | Completed research grants |
| 13 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 23 / 16 | All research grants and scholarships |
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