graduate in Dentistry at University of São Paulo (1982), , specilist in Periodontology(1985), Master(1990) and ph.d. in Sicences - Microbiology, University of São Paulo (1996). Pos Doctoral in the Dept of Microbiology, School of Dental Medicine, University of Pennsylvania (1996-1998). (Source: Lattes Curriculum)
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We aim to establish the bases for the development of new strategies for the control of periodontitis. Our hypothesis is that the balance between the oral microbiota-immune response, lost in periodontitis, could be obtained by favoring the colonization of the oral cavity with beneficial bacterial species and by modulating the immune response. The first project aims to test if saliva differ…
Although previous studies suggested an anti-inflammatory property of Brazilian red propolis (BRP), the mechanisms involved in the anti-inflammatory effects of BRP and its activity on macrophages were still not elucidated. This study aimed to evaluate whether BRP attenuates the inflammatory effect of LPS on macrophages and to investigate its underlying mechanisms. BRP was added to RAW 264.…
Aggregatibacter actinomycetemcomitans serotypes are clearly associated with periodontitis or health, which suggests distinct strategies for survival within the host. We investigated the transcription profile of virulence associated genes in A. actinomycetemcomitans serotype b (JP2 and SUNY465) strains associated with disease and a (ATCC 29523) serotype associated with health. Bacteria wer…
(Only some records are available in English at this moment)
Periodontitis is a chronic multifactorial inflammatory disease associated with a dysbiotic biofilm that leads to the progressive destruction of tooth support tissues, one of the main causes of tooth loss. Previous in vitro and in vivo studies carried out in this laboratory have shown the potential of the probiotic strain Lactobacillus acidophilus LA5 to affect oral colonization and modula…
The formation of the dental biofilm begins by the adhesion of first colonizers species on a conditioning film adsorbed to the surface of the tooth, called acquired pellicle (APE), followed by proliferation and aggregation to the organisms initially adhered to. Data from our group showed that the differences in oral microbiome among patients with localized aggressive periodontitis (PAgL) a…
The aim of this study is to test the hypothesis that distinct of P. gingivalis strains differ in capacity for colonisation of the oral cavity and distant sites and determine the effect of probiotic strains of the genus Lactobacillus on colonization systemic and oral of P. gingivalis capsulated and non-capsulated in experimental periodontitis model using two strains of P. gingivalis. The e…
The medical use of probiotics is widely known, but the mechanisms involved on the control of inflammatory diseases, such as periodontitis, are still poorly explored. Probiotic bacteria can promote the modulation of mucosal and systemic immune response, under health or disease conditions. Previous in vitro studies performed in our laboratory revealed that Lactobacillus probiotics are able …
(Only some records are available in English at this moment)
Initial adhesion of bacteria to the dental surface is dependent on the acquired enamel pellicle, formed by proteins present in whole saliva. Studies on the microbiology of aggressive periodontitis indicate an increased proportion of periodontopathogens such as A.actinomycetemcomitans and P. gingivalis, but also decreased proportions of early colonizers such as streptococci and other benef…
Despite an association between diabetes mellitus and periodontal disease, the microbial diversity in periodontal sites and mechanisms by which oral pathogens relate to glycemic control in diabetics are still not elucidated. This study aims to determine the diversity of the subgingival microbiota of patients with type 2 diabetes mellitus with appropriate and inappropriate glucose balance. …
Aggregatibacter actinomycetemcomitans is an important periodontal pathogen associated with periodontal diseases and extra-oral infections as endocarditis. A. actinomycetemcomitans has the ability to adhere and invade and epithelial cells, and to survive and perpetuate in infected tissues, produces many virulence factors, including the cytolethal distending toxin (Cdt). In our previous res…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 19 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 41 / 16 | Completed scholarships in Brazil |
| 7 / 4 | Completed scholarships abroad |
| 69 / 30 | All research grants and scholarships |
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CV Lattes
ORCID