Marcia Pinto Alves Mayer
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate in Dentistry at University of São Paulo (1982), , specilist in Periodontology(1985), Master(1990) and ph.d. in Sicences - Microbiology, University of São Paulo (1996). Pos Doctoral in the Dept of Microbiology, School of Dental Medicine, University of Pennsylvania (1996-1998). (Source: Lattes Curriculum)
- New strategies for the control of periodontitis, AP.TEM
Abstract
We aim to establish the bases for the development of new strategies for the control of periodontitis. Our hypothesis is that the balance between the oral microbiota-immune response, lost in periodontitis, could be obtained by favoring the colonization of the oral cavity with beneficial bacterial species and by modulating the immune response. The first project aims to test if saliva diff...
- Brazilian red propolis attenuates inflammatory signaling cascade in LPS-activated macrophages, PUB.ART
Abstract
Although previous studies suggested an anti-inflammatory property of Brazilian red propolis (BRP), the mechanisms involved in the anti-inflammatory effects of BRP and its activity on macrophages were still not elucidated. This study aimed to evaluate whether BRP attenuates the inflammatory effect of LPS on macrophages and to investigate its underlying mechanisms. BRP was added to RAW 26...
- 93rd General Session & Exhibition of the IADR 2015, AR.EXT
- Differential transcription of virulence genes in Aggregatibacter actinomycetemcomitans serotypes, PUB.ART
Abstract
Aggregatibacter actinomycetemcomitans serotypes are clearly associated with periodontitis or health, which suggests distinct strategies for survival within the host. We investigated the transcription profile of virulence associated genes in A. actinomycetemcomitans serotype b (JP2 and SUNY465) strains associated with disease and a (ATCC 29523) serotype associated with health. Bacteria w...
(Only some records are available in English at this moment)
- Determination of adhesion efficiency of A. actinomycetemcomitans, S. gordonii and S. oralis on the acquired pellicle formed with saliva from patients with localized aggressive periodontitis and controls with family related and not related, BP.IC
Abstract
The formation of the dental biofilm begins by the adhesion of first colonizers species on a conditioning film adsorbed to the surface of the tooth, called acquired pellicle (APE), followed by proliferation and aggregation to the organisms initially adhered to. Data from our group showed that the differences in oral microbiome among patients with localized aggressive periodontitis (PAgL)...
- Evaluation of the effect of probiotic bacteria on the imune response to A.actinomycetemcomitans: a study in gingival epithelial cells and in experimental model of infection in vivo, BP.DR
Abstract
The project aims to test the hypothesis that probiotic microorganisms or their products are able to control periodontitis induced by Aggregatibacter actinomycetemcomitans (Aa) by regulating the immune response to this pathogen. Initial results indicate that probiotics L.rhamnosus Lr32 and HN001 and L. acidophilus NCFM and La5 interfere with fimbria mediated biofilm formation of A. actin...
- Direct and immunomodulatory effects of probiotic bacteria on periodontal pathogens, BP.PD
Abstract
Periodontal disease (PD) is an infectious disease that affects approximately 25% of the world population. PD compromises the periodontal tissues supporting the tooth , causing loss of teeth. Besides these effects, PD may affect the health of the individuals, because it is associated with an increased risk of systemic disease. Microbial diversity studies have confirmed that some microorg...
(Only some records are available in English at this moment)
- Effect of probiotics on the genus Lactobacillus on oral colonization and spread of P. gingivalis systemic in experimental periodontitis model in mice, BP.IC
Abstract
The aim of this study is to test the hypothesis that distinct of P. gingivalis strains differ in capacity for colonisation of the oral cavity and distant sites and determine the effect of probiotic strains of the genus Lactobacillus on colonization systemic and oral of P. gingivalis capsulated and non-capsulated in experimental periodontitis model using two strains of P. gingivalis. The...
- Effect of probiotic lactobacilli on the modulation of inflammassome and alveolar bone loss promoted by experimental periodontitis in healthy mice, BP.MS
Abstract
The medical use of probiotics is widely known, but the mechanisms involved on the control of inflammatory diseases, such as periodontitis, are still poorly explored. Probiotic bacteria can promote the modulation of mucosal and systemic immune response, under health or disease conditions. Previous in vitro studies performed in our laboratory revealed that Lactobacillus probiotics are abl...
- Effect of Bifidobacterium probiotics on the modulation of immune response and alveolar bone loss in an experimental periodontitis model on normoglycemic and diabetic mice, BP.MS
Abstract
Although the use of probiotics is very common, their efficacy on the prevention and control of inflammatory diseases is strain-dependent. Our previous data have shown data probiotics belonging to the genus Bifidobacterium are able to reduce the formation of a multispecies biofilm including Porphyromonas gingivalis and Streptococcus species, and to interfere on the adhesion and invasion ...
(Only some records are available in English at this moment)
- Proteome of saliva and acquired pellicle and its correlation with the microbiome of supra and subgingival biofilms in aggressive periodontitis, BE.EP.DR
Abstract
Initial adhesion of bacteria to the dental surface is dependent on the acquired enamel pellicle, formed by proteins present in whole saliva. Studies on the microbiology of aggressive periodontitis indicate an increased proportion of periodontopathogens such as A.actinomycetemcomitans and P. gingivalis, but also decreased proportions of early colonizers such as streptococci and other ben...
- Analysis of data from 16SrRNA sequencing generated by high throughput of subgingival biofilm samples from diabetic patients, BE.EP.PD
Abstract
Despite an association between diabetes mellitus and periodontal disease, the microbial diversity in periodontal sites and mechanisms by which oral pathogens relate to glycemic control in diabetics are still not elucidated. This study aims to determine the diversity of the subgingival microbiota of patients with type 2 diabetes mellitus with appropriate and inappropriate glucose balance...
- Analysis of cytolethal distending toxin (CDT) effect in inflammasome activation, BE.EP.PD
Abstract
Aggregatibacter actinomycetemcomitans is an important periodontal pathogen associated with periodontal diseases and extra-oral infections as endocarditis. A. actinomycetemcomitans has the ability to adhere and invade and epithelial cells, and to survive and perpetuate in infected tissues, produces many virulence factors, including the cytolethal distending toxin (Cdt). In our previous r...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 19 / 8 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 37 / 12 | Completed scholarships in Brazil |
| 7 / 4 | Completed scholarships abroad |
| 68 / 29 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 28 |
| Citations | 394 |
| Cit./Article | 14.1 |
| Data from Web of Science | |
LONGO, PRISCILA L.; DABDOUB, SHAREEF; KUMAR, PURNIMA; ARTESE, HILANA P. C.; DIB, SERGIO A.; ROMITO, GIUSEPPE A.; ALVES MAYER, MARCIA PINTO. Glycaemic status affects the subgingival microbiome of diabetic patients. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 45, n. 8, p. 932-940, AUG 2018. Web of Science Citations: 4. (11/10057-4, 13/20537-9, 11/18618-5)
MATSUBARA, VICTOR H.; ISHIKAWA, KARIN H.; ANDO-SUGUIMOTO, ELLEN S.; BUENO-SILVA, BRUNO; NAKAMAE, ATLAS E. M.; MAYER, MARCIA P. A.. Probiotic Bacteria Alter Pattern-Recognition Receptor Expression and Cytokine Profile in a Human Macrophage Model Challenged with Candida albicans and Lipopolysaccharide. FRONTIERS IN MICROBIOLOGY, v. 8, NOV 29 2017. Web of Science Citations: 8. (15/18273-9)
KAWAMOTO, DIONE; ANDO-SUGUIMOTO, ELLEN S.; BUENO-SILVA, BRUNO; DIRIENZO, JOSEPH M.; MAYER, MARCIA P. A.. Alteration of Homeostasis in Pre-osteoclasts Induced by Aggregatibacter actinomycetemcomitans CDT. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 6, MAR 31 2016. Web of Science Citations: 0.
BUENO-SILVA, BRUNO; KAWAMOTO, DIONE; ANDO-SUGUIMOTO, ELLEN S.; ALENCAR, SEVERINO M.; ROSALEN, PEDRO L.; MAYER, MARCIA P. A.. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS One, v. 10, n. 12, DEC 14 2015. Web of Science Citations: 17. (12/14323-3, 12/01500-4)
BUENO-SILVA, BRUNO; KAWAMOTO, DIONE; ANDO-SUGUIMOTO, ELLEN S.; CASARIN, RENATO C. V.; ALENCAR, SEVERINO M.; ROSALEN, PEDRO L.; MAYER, MARCIA P. A.. Brazilian red propolis effects on peritoneal macrophage activity: Nitric oxide, cell viability, pro-inflammatory cytokines and gene expression. Journal of Ethnopharmacology, v. 207, p. 100-107, JUL 31 2017. Web of Science Citations: 11. (12/14323-3, 12/01500-4)
LONGO, P. L.; NUNES, A. C. R.; UMEDA, J. E.; MAYER, M. P. A.. Gene expression and phenotypic traits of Aggregatibacter actinomycetemcomitans in response to environmental changes. JOURNAL OF PERIODONTAL RESEARCH, v. 48, n. 6, p. 766-772, DEC 2013. Web of Science Citations: 6. (03/08598-0)
REBEIS, ESTELA SANCHES; ALBUQUERQUE-SOUZA, EMMANUEL; DA SILVA, MAIKE PAULINO; GIUDICISSI, MARCELA; MAYER, MARCIA P. A.; SARAIVA, LUCIANA. Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A-actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients. ORAL DISEASES, v. 25, n. 2, p. 569-579, MAR 2019. Web of Science Citations: 1. (10/16162-1, 12/05911-9, 13/26381-0)
FREIRES, IRLAN ALMEIDA; BUENO-SILVA, BRUNO; DE CARVALHO GALVAO, LIVIA CAMARA; TEIXEIRA DUARTE, MARTA CRISTINA; SARTORATTO, ADILSON; FIGUEIRA, GLYN MARA; DE ALENCAR, SEVERINO MATIAS; ROSALEN, PEDRO LUIZ. The Effect of Essential Oils and Bioactive Fractions on Streptococcus mutans and Candida albicans Biofilms: A Confocal Analysis. Evidence-based Complementary and Alternative Medicine, 2015. Web of Science Citations: 6. (11/15984-0, 12/01500-4, 11/14757-0, 09/12353-0)
MATARAZZO, FLAVIA; RIBEIRO, ADRIANA COSTA; FERES, MAGDA; FAVERI, MARCELO; ALVES MAYER, MARCIA PINTO. Diversity and quantitative analysis of Archaea in aggressive periodontitis and periodontally healthy subjects. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 38, n. 7, p. 621-627, JUL 2011. Web of Science Citations: 42. (07/56413-0)
GONCALVES, L. F. H.; FERMIANO, D.; FERES, M.; FIGUEIREDO, L. C.; TELES, F. R. P.; MAYER, M. P. A.; FAVERI, M.. Levels of Selenomonas species in generalized aggressive periodontitis. JOURNAL OF PERIODONTAL RESEARCH, v. 47, n. 6, p. 711-718, DEC 2012. Web of Science Citations: 25. (09/12358-1)
GONCALVES, L. F. H.; FERMIANO, D.; FERES, M.; FIGUEIREDO, L. C.; TELES, F. R. P.; MAYER, M. P. A.; FAVERI, M.. Levels of Selenomonas species in generalized aggressive periodontitis. JOURNAL OF PERIODONTAL RESEARCH, v. 47, n. 6, p. 711-718, DEC 2012. Web of Science Citations: 25. (09/12358-1)
BUENO-SILVA, BRUNO; KAWAMOTO, DIONE; ANDO-SUGUIMOTO, ELLEN S.; ALENCAR, SEVERINO M.; ROSALEN, PEDRO L.; MAYER, MARCIA P. A.. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS One, v. 10, n. 12, DEC 14 2015. Web of Science Citations: 17. (12/14323-3, 12/01500-4)
LONGO, P. L.; NUNES, A. C. R.; UMEDA, J. E.; MAYER, M. P. A.. Gene expression and phenotypic traits of Aggregatibacter actinomycetemcomitans in response to environmental changes. JOURNAL OF PERIODONTAL RESEARCH, v. 48, n. 6, p. 766-772, DEC 2013. Web of Science Citations: 6. (03/08598-0)
PINHEIRO, E. T.; KAWAMOTO, D.; OTA-TSUZUKI, C.; ALMEIDA, L. R. S.; NUNES, A. C. R.; LONGO, P. L.; WIKSTROM, M.; MAYER, M. P. A.. Analysis of genotypic variation in genes associated with virulence in Aggregatibacter actinomycetemcomitans clinical isolates. JOURNAL OF PERIODONTAL RESEARCH, v. 46, n. 3, p. 310-317, JUN 2011. Web of Science Citations: 5. (03/08598-0)
KAWAMOTO, D.; ANDO, E. S.; LONGO, P. L.; NUNES, A. C. R.; WIKSTROM, M.; MAYER, M. P. A.. Genetic diversity and toxic activity of Aggregatibacter actinomycetemcomitans isolates. Oral Microbiology and Immunology, v. 24, n. 6, p. 493-501, DEC 2009. Web of Science Citations: 23. (03/08598-0)
LOUREIRO TEIXEIRA, SILVIA REGINA; SOARES D'EPIRO, TALYTA THEREZA; PINHEIRO, ERICKA TAVARES; SIMIONATO, MARIA REGINA L.; TANIWAKI, NOEMI NOSOMI; KISIELIUS, JONAS JOSE; ALVES MAYER, MARCIA PINTO. Lineage variability in surface components expression within Porphyromonas gingivalis. Microbial Pathogenesis, v. 77, p. 100-104, DEC 2014. Web of Science Citations: 1. (09/13029-1)
LONGO, P. L.; OTA-TSUZUKI, C.; NUNES, A. C. R.; FERNANDES, B. L.; MINTZ, K.; FIVES-TAYLOR, P.; MAYER, M. P. A.. Aggregatibacter actinomycetemcomitans arcB INFLUENCES HYDROPHOBIC PROPERTIES, BIOFILM FORMATION AND ADHESION TO HYDROXYAPATITE. Brazilian Journal of Microbiology, v. 40, n. 3, p. 550-562, SEP 2009. Web of Science Citations: 2. (03/08598-0)
RIBEIRO, ADRIANA C.; MATARAZZO, FLAVIA; FAVERI, MARCELO; ZEZELL, DENISE M.; MAYER, MARCIA P. A.. Exploring Bacterial Diversity of Endodontic Microbiota by Cloning and Sequencing 16S rRNA. JOURNAL OF ENDODONTICS, v. 37, n. 7, p. 922-926, JUL 2011. Web of Science Citations: 26.
FAVERI, MARCELO; FIGUEIREDO, LUCIENE CRISTINA; DUARTE, POLIANA MENDES; MESTNIK, MARIA JOSEFA; ALVES MAYER, MARCIA PINTO; FERES, MAGDA. Microbiological profile of untreated subjects with localized aggressive periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 36, n. 9, p. 739-749, SEP 2009. Web of Science Citations: 91.
OTA-TSUZUKI, CLAUDIA; ALVES MAYER, MARCIA PINTO. Collagenase production and hemolytic activity related to 16S rRNA variability among Parvimonas micra oral isolates. Anaerobe, v. 16, n. 1, p. 38-42, FEB 2010. Web of Science Citations: 7.
BUENO-SILVA, BRUNO; FRANCHIN, MARCELO; ALVES, CLAUDINEY DE FREITAS; DENNY, CARINA; COLON, DAVID FERNANDO; CUNHA, THIAGO MATTAR; ALENCAR, SEVERINO MATIAS; NAPIMOGA, MARCELO HENRIQUE; ROSALEN, PEDRO LUIZ. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine, v. 23, n. 13, p. 1583-1590, DEC 1 2016. Web of Science Citations: 15. (12/22378-2, 12/01365-0, 12/01500-4)
CALANDRINI, C. A.; RIBEIRO, A. C.; GONNELLI, A. C.; OTA-TSUZUKI, C.; RANGEL, L. P.; SABA-CHUJFI, E.; MAYER, M. P. A.. Microbial composition of atherosclerotic plaques. ORAL DISEASES, v. 20, n. 3, p. e128-e134, APR 2014. Web of Science Citations: 25.
ANDO-SUGUIMOTO, ELLEN SAYURI; DA SILVA, MAIKE PAULINO; KAWAMOTO, DIONE; CHEN, CASEY; DIRIENZO, JOSEPH M.; ALVES MAYER, MARCIA PINTO. The cytolethal distending toxin of Aggregatibacter actinomycetemcomitans inhibits macrophage phagocytosis and subverts cytokine production. CYTOKINE, v. 66, n. 1, p. 46-53, MAR 2014. Web of Science Citations: 20.
LONGO, PRISCILA LARCHER; CARILLO ARTESE, HILANA PAULA; RABELO, MARIANA DE SOUSA; KAWAMOTO, DIONE; FOZ, ADRIANA MOURA; ROMITO, GIUSEPPE ALEXANDRE; DIB, SERGIO ATALA; ALVES MAYER, MARCIA PINTO. Serum levels of inflammatory markers in type 2 diabetes patients with chronic periodontitis. Journal of Applied Oral Science, v. 22, n. 2, p. 103-108, MAR-APR 2014. Web of Science Citations: 17. (11/18618-5)
UMEDA, JOSELY EMIKO; LONGO, PRISCILA LARCHER; LORENZETTI SIMIONATO, MARIA REGINA; ALVES MAYER, MARCIA PINTO. Differential transcription of virulence genes in Aggregatibacter actinomycetemcomitans serotypes. JOURNAL OF ORAL MICROBIOLOGY, v. 5, 2013. Web of Science Citations: 2. (03/08598-0)
ALBUQUERQUE-SOUZA, EMMANUEL; BALZARINI, DANILO; ANDO-SUGUIMOTO, ELLEN S.; ISHIKAWA, KARIN H.; SIMIONATO, MARIA R. L.; HOLZHAUSEN, MARINELLA; MAYER, MARCIA P. A.. Probiotics alter the immune response of gingival epithelial cells challenged by Porphyromonas gingivalis. JOURNAL OF PERIODONTAL RESEARCH, v. 54, n. 2, p. 115-127, APR 2019. Web of Science Citations: 0. (15/18273-9, 16/14687-6)
BUENO-SILVA, BRUNO; ROSALEN, PEDRO L.; ALENCAR, SEVERINO M.; MAYER, MARCIA P. A.. Anti-inflammatory mechanisms of neovestitol from Brazilian red propolis in LPS-activated macrophages. Journal of Functional Foods, v. 36, p. 440-447, SEP 2017. Web of Science Citations: 6. (12/14323-3, 12/01500-4)
PL LONGO; C OTA-TSUZUKI; ACR NUNES; BL FERNANDES; K MINTZ; P FIVES-TAYLOR; MPA MAYER. Aggregatibacter actinomycetemcomitansarcB influences hydrophobic properties, biofilm formation and adhesion to hydroxyapatite. Brazilian Journal of Microbiology, v. 40, n. 3, p. -, Set. 2009. (03/08598-0)
BUENO-SILVA, BRUNO; ROSALEN, PEDRO L.; ALENCAR, SEVERINO M.; MAYER, MARCIA P. A.. Vestitol drives LPS-activated macrophages into M2 phenotype through modulation of NF-kappa B pathway. International Immunopharmacology, v. 82, MAY 2020. Web of Science Citations: 0. (12/14323-3, 12/01500-4)
PRISCILA LARCHER LONGO; HILANA PAULA CARILLO ARTESE; MARIANADE SOUSA RABELO; DIONE KAWAMOTO; ADRIANA MOURA FOZ; GIUSEPPE ALEXANDRE ROMITO; SÉRGIO ATALA DIB; MARCIA PINTO ALVES MAYER. Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis. Journal of Applied Oral Science, v. 22, n. 2, p. -, Abr. 2014. (11/18618-5)
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Maike Paulino da. OMP29 de Aggregatibacter actinomycetemcomitans: análise filogenética, interação com proteínas de matriz e resposta de células epiteliais.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/18683-1)
ZI, Marcela Yang Hui. Efeitos da infecção experimental por Porphyromonas gingivalis e Aggregatibacter actinomycetemcomitans no padrão de prenhez de camundongos e em marcadores inflamatórios.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/10549-2)
UMEDA, Josely Emiko. Análise da expressão gênica após a interação entre Aggregatibacter actinomycetemcomitans e célula epitelial.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/58903-0)
MATARAZZO, Flávia. Diversidade e análise quantitativa de microrganismos do dominio Archaea em amostras de biofilme subgengival de individuos com periodontite agressiva e saúde periodontal.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/56509-8)
TEIXEIRA, Silvia Regina Loureiro. Análise da variabilidade de sistema de regulação de dois componentes FimSR e expressão do operon fimA em Porphyromonas gingivalis.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/50191-1)
D'EPIRO, Talyta Thereza Soares. Estrutura populacional, características fenotípicas e variabilidade do lócus de síntese do polissacarídeo capsular de amostras de Porphyromonas gingivalis.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/13029-1)
FAVERI, Marcelo de. Diversidade bacteriana por análise clonal de 16S rRNA e pela hidridação DNA-DNA em amostras de biofilme subgengival de indivíduos portadores de periodontite agressiva.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/59443-2)
LONGO, Priscila Larcher. Construção, análise do fenótipo e da transcrição gênica de uma amostra mutante de Aggregatibacter actinomycetemcomitans deficiente em arcB.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (03/01192-9)
OTA-TSUZUKI, Claudia. Análise dos fatores de virulência e genotipagem de isolados de Micromonas micros. 91 f. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (00/10047-4)
NUNES, Ana Carla Robatto. O papel de Aae na adesão às proteínas de matriz extracelular e sua influência nas propriedades hidrofóbicas e formação de biofilme por Aggregatibacter actinomycetemcomitans.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (03/11172-5)
USO DA COMBINAÇÃO NEOVESTITOL E VESTITOL PARA TRATAMENTO E PREVENÇÃO DA ATEROSCLEROSE BR1020170166031 - Universidade Estadual de Campinas (UNICAMP). Pedro Luiz Rosalen; Severino M. Alencar; Marcia Pinto Alves Mayer; Bruno Bueno Silva - August 2017, 02