CV Lattes
Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1981), master's at Genetics from Universidade Estadual Paulista Júlio de Mesquita Filho (1985) and ph.d. at Genetics from Universidade Estadual Paulista Júlio de Mesquita Filho (1991). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: cancer gastrico, genetica, polimorfismos genéticos, fish and genetica molecular. (Source: Lattes Curriculum)
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Gastric adenocarcinoma is often associated with H. pylori infection, it induces an inflammatory and immune response in the host leading to the activation of pro- and anti-inflammatory mediators that produce reactive oxygen species (ROS) and nitrogen in the infected mucosa increasing oxidative stress, genotoxic and DNA damage. As a result, the occurrence of genetic instability, changes in …
H. pylori cause chronic inflammation favoring gastric carcinogenesis and its eradication may prevent malignant transformation. We evaluated whether H. pylori infection and its eradication modify the expression of inflammatory mediators in patients with chronic gastritis. Furthermore, we assessed whether microRNAs modulate inflammatory pathways induced by H. pylori and identified miRNA-gen…
Helicobacter pylori (Hp) is recognized by TLR4 and TLR2 receptors, which trigger the activation of genes involved in the host immune response. Thus, we evaluated the effect of eradication therapy on TLR2 and TLR4 mRNA and protein expression in H. pylori-infected chronic gastritis patients (CG-Hp+) and 3 months after treatment. A total of 37 patients CG-Hp+ were evaluated. The relative qua…
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Persistent infection by Helicobacter pylori causes chronic inflammation and consequent development of gastric lesions that may progress to intestinal type gastric cancer. The inflammatory response triggered by this pathogen is characterized by the induction of inflammatory cytokines expression, highlighting the tumor necrosis factor (TNF)-± as presenting tumor promoting function. TNF-± si…
Chronic inflammation provides a favorable microenvironment for neoplastic transformation, often due to persistent infection by pathogens. In this model, fits in gastric cancer as a result of infection by the bacterium Helicobacter pylori. Persistent infection by this bacterium promotes chronic inflammation, the main etiological factor for stomach cancer progression from atrophic gastritis…
Gastric cancer remains the second leading cause of cancer-related death worldwide, despite the reduction in its incidence. The main risk factors consist of premalignant lesions of the gastric mucosa, such as chronic gastritis, metaplasia and dysplasia, often initiated by chronic inflammation caused by the bacterium Helicobacter pylori. Gastric ulcer, a chronic injury of the gastric mucosa…
| 20 / 8 | Completed research grants |
| 11 / 3 | Completed scholarships in Brazil |
| 31 / 11 | All research grants and scholarships |
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