Graduate at Farmácia e Bioquímica from Universidade Federal de Alfenas (1977), master's at Pharmacy from Universidade de São Paulo (1983) and PhD at Science and Technology of the Food from Universidade de São Paulo (1985). Has experience in Pharmacy, acting on the following subjects: polimorphism, atherosclerose, PCR, PCR and real time RT-PCR. (Source: Lattes Curriculum)
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Obesity prevalence has increased dramatically in at least threefold in last three decades becoming a very important problem in health public. Obesity is epidemiologically determinate as a high-risk factor for developing diseases, including cardiovascular diseases (CVDs). The complexity multifactor etiology of these diseases needs the application of Integrative tool interplaying environmen…
Familial hypercholesterolemia (FH) is an autosomal dominant disease with genetic basis not fully understood yet. This study aims to investigate the genomics, epigenomics and pharmacogenomics bases of monogenic and polygenic FH. Patients with FH diagnosed phenotypically will be recruited in six research centers from different regions of Brazil. The methods include: (i) Ultra deep DNA seque…
Dead cells as a result of tissue damage are quickly engulfed, but before disappearing, warn the surrounding cells so that repair programs are activated. The recognition of cell damage by the innate immune system contributes to the development of inflammatory immune responses and tissue repair, but may also exacerbate tissue injuries. In some cases, uncontrolled cell death can trigger a ca…
Sudden cardiac death (SCD) is a major health problem with an incidence of 30-200/100000 people each year. Atherosclerosis and acquired forms of cardiomyopathies are the most frequent findings in adults with SCD whereas in people under 35 years old, non ischemic diseases are responsible for a large number of cases. Particularly, an important number of previously healthy young people who di…
Tuberculosis (TB) is responsible for the annual death of two to three million people in the world, and since 1960, no new specific drug was discovered against M. tuberculosis. For the viability of this new drug, it should shorten the treatment time to be active against strains resistant and/or MDR and be active against latent bacilli. In this sense, compounds of thiosemicarbazones and hyd…
Tuberculosis treatment is cumbersome and requires at least six months for completion. There are a reduced number of drugs available for the treatment and the acquisition of resistance became a world public health problem. The ability to survive in harsh environments, including macrophages, for long periods of time has been described as one of the most import ability of Mycobacterium tuber…
(Only some records are available in English at this moment)
Statins are currently the most prescribed drug against dyslipidemia. However, considered safe, statins are associated with several adverse effects, especially those related to myalgia, rhabdomyolysis and other muscle symptoms related to the use of statins (SMRE), which account for about 65% of cases of low adherence to treatment. This low adherence to treatment, consequently, leads to inc…
Familial hypercholesterolemia (FH) is an autosomal dominant disease, present in all ethnic groups, that affects cholesterol metabolism, reducing the catabolism of LDL particles and resulting in high plasma concentrations of these particles, with genetic bases not yet fully understood. In recent years, more comprehensive technologies have been used for the genotypic research of HF in the w…
Familial hypercholesterolemia (FH) is a genetic disease characterized by high concentrations of low-density protein cholesterol (LDL-c), increasing cardiovascular risk. The molecular diagnosis of HF is based on analyzing genes that cause autosomal dominant HF. However, although several functional mutations associated with HF have already been described in the LDLR, APOB, and PCSK9, other …
(Only some records are available in English at this moment)
Familial hypercholesterolemia (FH) is an autosomal dominant disease, present in all ethnic groups, that affects cholesterol metabolism, reducing the catabolism of LDL particles and resulting in high plasma concentrations of these particles, with genetic bases not yet fully understood. In recent years, more comprehensive technologies have been used for the genotypic research of HF in the w…
Currently, only the clinical evaluation of patients with high levels of serum cholesterol has been shown to be insufficient for the correct identification of FH cases. Thus, to increase the diagnostic accuracy of this condition, molecular diagnostic tools have proved to be adequate and important strategies. This pathology is characterized by genetic variants found in four main genes, LDLR…
The molecular bases of monogenic hypercholesterolemia are associated with: 1. reduced activity of the low-density lipoprotein (LDLR) receptor, consequently with low LDL plasma clearance. 2. The conformational alterations of Apolipoprotein B 100 (ApoB-100), the main LDL protein, responsible for binding to the receptor, which alters affinity, which also leads to low plasma removal of LDL (A…
(Only some records are available in English at this moment)
Statins are one of the most prescribed drugs worldwide. Despite being considered safe, they are associated with several side effects, mainly those related to muscle symptoms, which represent up to 65% of low adherence cases. Statin-associated muscle symptoms (SAMS) are largely studied, but molecular mechanisms are not yet fully understood. Most studies focused on skeletal muscle and some …
Familial Hypercholesterolemia (FH) is a hereditary disorder characterized by elevated low-density lipoprotein (LDL) cholesterol and premature cardiovascular disease, which has genetic basis not fully understood yet. Exosomes molecular content can be useful for diagnostic purposes. Particularly proteins and miRNAs has been identified in exosomes purified from different biological fluids an…
The ability to survive in harsh environments, including within macrophages, has been described as one of the most important abilities of Mycobacterium tuberculosis. Although important, the gene expression of persistent M. Tuberculosis is still not fully elucidated. In this project we are assessing the global gene expression of M. Tuberculosis strains within multinucleated giant macropha…
| 3 / 3 | Ongoing research grants |
| 25 / 15 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 23 / 21 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 59 / 47 | All research grants and scholarships |
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CV Lattes
ORCID