CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation for the last research proposal) Birthplace: Brazil
Ph.D. (General Physiology) by USP in 1998. Postdoctoral at Universidad de Cádiz (1998-1999) and Euskal Herriko Unibertsitatea (1999-2000). Executive coordinator and supervisor of projects for scientific and technological innovation, postgraduate's teacher and supervisor, social entrepreneur, and ad hoc advisor of funding agencies, scientific publications and for the National Evaluation System of Higher Education (MEC/INEP) in biomedical area, acting as Scientific Researcher VI of the Instituto Butantan, in the areas of Translational Physiology, Pharmacology and Toxinology, with emphasis on Experimental Endocrinology. Leadership of the institutional research group on Pharmacology and Translational and Endocrine Physiology, which is certificated by CNPq. (Source: Lattes Curriculum)
Problem under study: Exenatide is the unique molecule derived from animal venom (Gila monster, Heloderma suspectum) that is among the most recent pharmacological resources for diabetes mellitus (DM) type 2. This drug presents agonism on glucagon-like peptide-1 hormone (GLP-1) receptor (R) and resistance to the hydrolysis by dipeptidyl-peptidase IV. There are evidences that GLP-1 and exena…
Metabolic syndrome is close related to diabetes mellitus type 2, obesity and neurodegenerative processes, being a serious public health problem. In turn, muscarinic receptors in the hippocampus participate decisively in the modulation of cognitive functions, learning and memory, which are compromised in neurodegenerative processes. Among the most recent pharmacological resources for diabe…
Metabolic disorders, such as obesity and anorexia, change the reserve of energy and functionality of adipocytes. The discovery of insulin-regulated aminopeptidase, which hydrolyses peptides such as oxytocin and vasopressin and binds angiotensin IV, highlights the importance of studying the involvement of peptidases in the endocrine function of adipose tissue. Peptide YY, neuropeptide Y, b…
(Only some records are available in English at this moment)
Problem under study: Among the most recent pharmacological resources for diabetes mellitus (DM) type 2 there is the exenatide, which was developed from a peptide isolated from the Gila monster (Heloderma suspectum) venom and presenting agonism on glucagon-like peptide-1 hormone receptor and resistance to the hydrolysis by dipeptidyl-peptidase IV. There are evidences that this drug can be …
Metabolic syndrome is close related to diabetes mellitus type II and visceral obesity, being a serious public health problem. Vildagliptin and sitagliptin, inhibitors of dipeptidyl-peptidase IV (DPP-IV) (EC 3.4.14.5), the enzyme responsible for the cleavage of glucagon-like peptide-1 hormone (GLP-1), as well exenatide, which was developed from Heloderma suspectum lizard venom, and liraglu…
Rheumatoid arthritis affects about 1% of the worldwide population. It is characterised by cellular infiltration in the synovium, progressive erosion of cartilage and bone and pannus formation in the affected joints, as well the immune response to cartilage components and the presence of rheumatoid factors. Several mechanisms are involved in the disease establishment and chronicicity, as t…
(Only some records are available in English at this moment)
| 13 / 10 | Completed research grants |
| 8 / 5 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 22 / 15 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 100 |
| Cit./Article | 5.6 |
| Data from Web of Science | |
BARONE, JULIANA MARTON; FREZZATTI, RODRIGO; SILVEIRA, PAULO FLAVIO. Effects of N-acetyl-L-cysteine on redox status and markers of renal function in mice inoculated with Bothrops jararaca and Crotalus durissus terrificus venoms. Toxicon, v. 79, p. 1-10, MAR 1 2014. Web of Science Citations: 3. (06/06926-9)
ALPONTI, RAFAELA FADONI; VIANA, LUCIANA GODOY; YAMANOUYE, NORMA; SILVEIRA, PAULO FLAVIO. Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity. JOURNAL OF MOLECULAR ENDOCRINOLOGY, v. 55, n. 1, p. 1-8, AUG 2015. Web of Science Citations: 3. (10/01385-5)
MENDES, MARIANA TRIVILIN; SILVEIRA, PAULO FLAVIO. The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats. BIOMED RESEARCH INTERNATIONAL, 2014. Web of Science Citations: 4. (09/17613-0)
ALVES, PATRICIA LUCIO; FRANCIS ABDALLA, FERNANDO MAURICIO; ALPONTI, RAFAELA FADONI; SILVEIRA, PAULO FLAVIO. Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster. Toxicon, v. 135, p. 1-11, SEP 1 2017. Web of Science Citations: 1. (12/12105-9)
ALPONTI, RAFAELA FADONI; NOGUEIRA, MARIA INES; MENDES, MARIANA TRIVILIN; DE ABREU, CINTYA; SILVEIRA, PAULO FLAVIO. APM/CD13 and FOS in the hypothalamus of monosodium glutamate obese and food deprived rats. Regulatory Peptides, v. 166, n. 1-3, p. 98-104, JAN 17 2011. Web of Science Citations: 5. (05/04699-2)
ALPONTI, RAFAELA F.; SILVEIRA, PAULO F.. Neutral Aminopeptidase and Dipeptidyl Peptidase IV Activities in Plasma of Monosodium Glutamate Obese and Food-deprived Rats. OBESITY, v. 18, n. 7, p. 1312-1317, JUL 2010. Web of Science Citations: 9. (05/04699-2)
MARINHO, CAMILA EDUARDO; ALMEIDA-SANTOS, SELMA MARIA; CARNEIRO, SYLVIA MENDES; YAMASAKI, SIMONE CRISTINA; SILVEIRA, PAULO FLAVIO. Peptidase activities in Crotalus durissus terrificus semen. Reproduction, v. 136, n. 6, p. 767-776, DEC 2008. Web of Science Citations: 2. (05/03745-0, 07/06829-6)
MARINHO‚ C.E.; OLIVO‚ R.A.; ZAMBOTTI-VILLELA‚ L.; RIBEIRO-DE-ANDRADE‚ T.N.; FERNANDES‚ C.M.; SILVEIRA‚ P.F.. Renal and macrophage aminopeptidase activities in cyclosporin-treated mice. International Immunopharmacology, v. 6, n. 3, p. 415-425, 2006.
SILVEIRA, P. F.; BRENO, M. C.; MARTÍN DEL RÍO, M. P.; MANCERA, J. M.. The distribution of vasotocin and mesotocin immunoreactivity in the brain of the snake, Bothrops jararaca. Journal of Chemical Neuroanatomy, v. 24, n. 1, p. 15-26, 2002.
ALEGRE, VALTER DE SOUSA; BARONE, JULIANA MARTON; YAMASAKI, SIMONE CRISTINA; ZAMBOTTI-VILLELA, LEONARDO; SILVEIRA, PAULO FLAVIO. Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice. Toxicon, v. 56, n. 3, p. 402-410, SEP 1 2010. Web of Science Citations: 11. (06/06926-9)
IRAZUSTA‚ J.; SILVEIRA‚ P. F.; GIL‚ J.; VARONA‚ A.; CASIS‚ L.. Effects of hydrosaline treatments on prolyl endopeptidase activity in rat tissues. Regulatory Peptides, v. 101, n. 1/3, p. 141-147, 2001.
ALPONTI, RAFAELA FADONI; SILVEIRA, PAULO FLAVIO. Adipocyte aminopeptidases in obesity and fasting. Molecular and Cellular Endocrinology, v. 415, n. C, p. 24-31, NOV 5 2015. Web of Science Citations: 1. (10/01385-5)
ALPONTI, RAFAELA FADONI; ALVES, PATRICIA LUCIO; SILVEIRA, PAULO FLAVIO. Novel adipocyte aminopeptidases are selectively upregulated by insulin in healthy and obese rats. Journal of Endocrinology, v. 228, n. 2, p. 97-104, FEB 2016. Web of Science Citations: 0. (10/01385-5)
YAMASAKI, SIMONE C.; MENDES, MARIANA T.; ALPONTI, RAFAELA F.; SILVEIRA, PAULO F.. Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: A comparison with methotrexate. Toxicon, v. 98, p. 75-88, MAY 2015. Web of Science Citations: 1. (07/08311-4)
MENDES, MARIANA TRIVILIN; MURARI-DO-NASCIMENTO, STEPHANIE; TORRIGO, ISIS ROSSETTI; ALPONTI, RAFAELA FADONI; YAMASAKI, SIMONE CRISTINA; SILVEIRA, PAULO FLAVIO. Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis. Regulatory Peptides, v. 167, n. 2-3, p. 215-221, APR 11 2011. Web of Science Citations: 4. (09/17613-0)
GASPARELLO-CLEMENTE‚ E.; CASIS‚ L.; VARONA‚ A.; GIL‚ J.; IRAZUSTA‚ J.; SILVEIRA‚ P.F.. Aminopeptidases in visceral organs during alterations in body fluid volume and osmolality. Peptides, v. 24, n. 9, p. 1367-1372, 2003.
FREZZATTI, RODRIGO; SILVEIRA, PAULO FLAVIO. Allopurinol Reduces the Lethality Associated with Acute Renal Failure Induced by Crotalus durissus terrificus Snake Venom: Comparison with Probenecid. PLoS Neglected Tropical Diseases, v. 5, n. 9, p. e1312, 2011. Web of Science Citations: 10. (09/00509-5)
YAMASAKI, SIMONE CRISTINA; MURARI-DO-NASCIMENTO, STEPHANIE; SILVEIRA, PAULO FLAVIO. Neutral aminopeptidase and dipeptidyl peptidase IV in the development of collagen II-induced arthritis. Regulatory Peptides, v. 173, n. 1-3, p. 47-54, JAN 10 2012. Web of Science Citations: 5. (07/08311-4)
SILVEIRA, P. F.; BRENO, M. C.; MARTÍN DEL RÍO, M. P.; MANCERA, J. M.. The distribution of vasotocin and mesotocin immunoreactivity in the brain of the snake, Bothrops jararaca. Journal of Chemical Neuroanatomy, v. 24, n. 1, p. 15-26, 2002.
MARINHO, CAMILA EDUARDO; ALMEIDA-SANTOS, SELMA MARIA; CARNEIRO, SYLVIA MENDES; YAMASAKI, SIMONE CRISTINA; SILVEIRA, PAULO FLAVIO. Peptidase activities in Crotalus durissus terrificus semen. Reproduction, v. 136, n. 6, p. 767-776, DEC 2008. Web of Science Citations: 2. (05/03745-0, 07/06829-6)
ALEGRE, VALTER DE SOUSA; BARONE, JULIANA MARTON; YAMASAKI, SIMONE CRISTINA; ZAMBOTTI-VILLELA, LEONARDO; SILVEIRA, PAULO FLAVIO. Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice. Toxicon, v. 56, n. 3, p. 402-410, SEP 1 2010. Web of Science Citations: 11. (06/06926-9)
MARINHO‚ C.E.; OLIVO‚ R.A.; ZAMBOTTI-VILLELA‚ L.; RIBEIRO-DE-ANDRADE‚ T.N.; FERNANDES‚ C.M.; SILVEIRA‚ P.F.. Renal and macrophage aminopeptidase activities in cyclosporin-treated mice. International Immunopharmacology, v. 6, n. 3, p. 415-425, 2006.
ALPONTI, RAFAELA FADONI; NOGUEIRA, MARIA INES; MENDES, MARIANA TRIVILIN; DE ABREU, CINTYA; SILVEIRA, PAULO FLAVIO. APM/CD13 and FOS in the hypothalamus of monosodium glutamate obese and food deprived rats. Regulatory Peptides, v. 166, n. 1-3, p. 98-104, JAN 17 2011. Web of Science Citations: 5. (05/04699-2)
ALPONTI, RAFAELA F.; SILVEIRA, PAULO F.. Neutral Aminopeptidase and Dipeptidyl Peptidase IV Activities in Plasma of Monosodium Glutamate Obese and Food-deprived Rats. OBESITY, v. 18, n. 7, p. 1312-1317, JUL 2010. Web of Science Citations: 9. (05/04699-2)
ALVES, PATRICIA LUCIO; FRANCIS ABDALLA, FERNANDO MAURICIO; ALPONTI, RAFAELA FADONI; SILVEIRA, PAULO FLAVIO. Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster. Toxicon, v. 135, p. 1-11, SEP 1 2017. Web of Science Citations: 1. (12/12105-9)
ALPONTI, RAFAELA FADONI; VIANA, LUCIANA GODOY; YAMANOUYE, NORMA; SILVEIRA, PAULO FLAVIO. Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity. JOURNAL OF MOLECULAR ENDOCRINOLOGY, v. 55, n. 1, p. 1-8, AUG 2015. Web of Science Citations: 3. (10/01385-5)
BARONE, JULIANA MARTON; FREZZATTI, RODRIGO; SILVEIRA, PAULO FLAVIO. Effects of N-acetyl-L-cysteine on redox status and markers of renal function in mice inoculated with Bothrops jararaca and Crotalus durissus terrificus venoms. Toxicon, v. 79, p. 1-10, MAR 1 2014. Web of Science Citations: 3. (06/06926-9)
MENDES, MARIANA TRIVILIN; SILVEIRA, PAULO FLAVIO. The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats. BIOMED RESEARCH INTERNATIONAL, 2014. Web of Science Citations: 4. (09/17613-0)