Ph.D. (General Physiology) by USP in 1998. Postdoctoral at Universidad de Cádiz (1998-1999) and Euskal Herriko Unibertsitatea (1999-2000). Executive coordinator and supervisor of projects for scientific and technological innovation, postgraduate's teacher and supervisor, social entrepreneur, and ad hoc advisor of funding agencies, scientific publications and for the National Evaluation System of Higher Education (MEC/INEP) in biomedical area, acting as Scientific Researcher VI of the Instituto Butantan, in the areas of Translational Physiology, Pharmacology and Toxinology, with emphasis on Experimental Endocrinology. Leadership of the institutional research group on Pharmacology and Translational and Endocrine Physiology, which is certificated by CNPq. (Source: Lattes Curriculum)
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Problem under study: Exenatide is the unique molecule derived from animal venom (Gila monster, Heloderma suspectum) that is among the most recent pharmacological resources for diabetes mellitus (DM) type 2. This drug presents agonism on glucagon-like peptide-1 hormone (GLP-1) receptor (R) and resistance to the hydrolysis by dipeptidyl-peptidase IV. There are evidences that GLP-1 and exena…
Metabolic syndrome is close related to diabetes mellitus type 2, obesity and neurodegenerative processes, being a serious public health problem. In turn, muscarinic receptors in the hippocampus participate decisively in the modulation of cognitive functions, learning and memory, which are compromised in neurodegenerative processes. Among the most recent pharmacological resources for diabe…
Metabolic disorders, such as obesity and anorexia, change the reserve of energy and functionality of adipocytes. The discovery of insulin-regulated aminopeptidase, which hydrolyses peptides such as oxytocin and vasopressin and binds angiotensin IV, highlights the importance of studying the involvement of peptidases in the endocrine function of adipose tissue. Peptide YY, neuropeptide Y, b…
(Only some records are available in English at this moment)
Problem under study: Among the most recent pharmacological resources for diabetes mellitus (DM) type 2 there is the exenatide, which was developed from a peptide isolated from the Gila monster (Heloderma suspectum) venom and presenting agonism on glucagon-like peptide-1 hormone receptor and resistance to the hydrolysis by dipeptidyl-peptidase IV. There are evidences that this drug can be …
Rheumatoid arthritis affects about 1% of the worldwide population. It is characterised by cellular infiltration in the synovium, progressive erosion of cartilage and bone and pannus formation in the affected joints, as well the immune response to cartilage components and the presence of rheumatoid factors. Several mechanisms are involved in the disease establishment and chronicicity, as t…
Metabolic syndrome is close related to diabetes mellitus type II and visceral obesity, being a serious public health problem. Vildagliptin and sitagliptin, inhibitors of dipeptidyl-peptidase IV (DPP-IV) (EC 3.4.14.5), the enzyme responsible for the cleavage of glucagon-like peptide-1 hormone (GLP-1), as well exenatide, which was developed from Heloderma suspectum lizard venom, and liraglu…
(Only some records are available in English at this moment)
| 13 / 10 | Completed research grants |
| 8 / 5 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 22 / 15 | All research grants and scholarships |
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CV Lattes
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