CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Bacharelado Em Ciências Biológicas from Universidade de São Paulo (1993), bachelor's at Licenciatura Em Ciências Biológicas from Universidade de São Paulo (1993) and doctorate at Physiology from Universidade de São Paulo (1998). Has experience in Pharmacology, acting on the following subjects: cytotoxicity, ecotoxicologia, citotoxicidade, lytechinus variegatus and atividade antitumoral. (Source: Lattes Curriculum)
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Marine Biotechnology studies are of strategic importance for the development of Brazil, a country that has the second largest continuous coastline in the world. In this context, technologies aimed at the sustainable use of marine ecosystem services involving biological, genetic, chemical and ecophysiological resources are essential for meeting the Sustainable Development Goals and other U…
Breast cancer is the most common malignancy in women globally. In general, 90% of primary and 50% of metastatic breast cancers respond to systemic agents initially but resistance to therapy is common. Tumours develop resistance to DNA-damaging chemotherapeutic agents, in part, due to enhanced DNA repair capacity. Combination therapies that induce DNA damage and disrupt the DNA damage repa…
Breast cancer is the most common malignancy in women globally. In general, 90% of primary and 50% of metastatic breast cancers respond to systemic agents initially but resistance to therapy is common. Tumours develop resistance to DNA-damaging chemotherapeutic agents, in part, due to enhanced DNA repair capacity. Combination therapies that induce DNA damage and disrupt the DNA damage repa…
Pharmaceuticals are considered emerging organic contaminants and concerns on their environmental impact have been raised in the last decades as they have been detected in the environment. Pharmaceuticals enter the aquatic environment mainly due to WWTP effluent discharges or after direct application for veterinary purposes, such as in aquaculture and animal-infection preventing. A commonl…
(Only some records are available in English at this moment)
Recently, marine biotechnology has assumed a prominent role with the institution of the Ocean Decade, by the UN, emerging as an important science field for the generation of socioeconomic development through the sustainable, creative, and inclusive use of marine biodiversity, as well as for the promotion of conservation programs for these ecosystems. Brazil, having the second largest cont…
Seriniquinone (SQ) and its derivatives comprise a group of substances with potent cytotoxic activity, showing selectivity for melanoma cell lines. These substances have presented a novel and distinct mechanism of action when compared to other quinones, through binding to dermcidin (DCD) and triggering autophagocytosis and apoptosis. One of the challenges for the advancement of SQ in the s…
Gliomas are tumors of the Central Nervous System that affect mainly the adult population, imposing a low survival rate, and the most frequent type, Glioblastoma, is characterized by high aggressiveness and a poor prognosis. The search for new therapies is essential in order to bring not only more drug options, but also the possibility of innovative treatments, including new therapeutic ta…
Cancer is the term used to designate a set of diseases that are characterized by the disordered growth of somatic cells, caused by an accumulation of multiple genetic and epigenetic mutations that give the cells the capacity for tissue invasion and metastasis. It is a multifactorial disease resulting from the interaction of different factors that promote carcinogenesis. Gliomas are Centra…
Cancer is a set of diseases characterized by the abnormal growth of cells in any tissue or organ, and represents the second cause of death in the world. In order to reduce this problem, the search for new antineoplastic drugs is still a major focus of research. In this context, marine natural products play a key role in the discovery of new substances with pharmacological potential, repre…
The most aggressive Skin Cancers is Melanoma, which has a high mortality rate and increasing incidence. The BRAFV600E protein ihibitors, the most recurrent mutation in Melanoma, came at the beginning of the decade as promising treatments, however, the high cost, adverse effects and frequent tumor resistance are limiting its therapeutic success. Given this, there is an urgent need to disco…
(Only some records are available in English at this moment)
Seriniquinone (SQ) and its derivatives are unique dermcidin (DCD) modulators. This protein seems to be involved in a range of cancer-related processes, including cell survival, migration, and cachexia. Despite its potential as a drug candidate, based on its promising in vitro efficacy data, little is known about the mechanism of action of SQ and the involvement of DCD in cancer biology. M…
Glioblastomas (GB) are neoplasms of the Central Nervous System characterised by diffusely infiltrative growth, high aggressiveness and poor prognosis, which mainly affect the adult population, imposing low survival rates. The unfolded protein response (UPR) could be an important mechanism that sustains GB cell survival and aggressiveness. Activated by a process related to ER stress, the U…
Melanoma is the one of the most aggressive and refractory type of cancer, with a remarkable ability to adapt to microenvironmental influences. Its high cellular plasticity and consequent acquired resistance is due by genetic and non-genetic mechanisms, resulting in a heterogeneous tumor with a phenotypic cell spectrum. Non-genetic alterations are associated with transcriptional reprogramm…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 13 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 31 / 27 | All research grants and scholarships |
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