CV Lattes
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Universidade de São Paulo (USP). Instituto de Física (IF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Fisica from Pontifícia Universidade Católica de São Paulo (1982), master's at Physic from Universidade de São Paulo (1986) and doctorate at Physic from Universidade de São Paulo (1991). Full Professor at USP, has experience on Physics, focusing on Liquids and Solids Structure; crystallography, acting on the following subjects: saxs, model membranes, photodynamic therapy, protein-protein interaction and protein-lipid interaction. Nowadays, IUPABs Council, editorail board of Biophysical Reviews and member of SAXS committee from synchrotron Elettra, Italy. (Source: Lattes Curriculum)
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The emergence of life diversity and complexity has been facilitated by intercellular communication, which is partially supported by a highly conserved pathway known as the conventional secretory pathway. This pathway involves the secretion of proteins containing a signal peptide through the endoplasmic reticulum-Golgi apparatus-final destination route. Although some questions remain open,…
A large fraction of the proteome of various organisms corresponds to polypeptides that do not form a defined three-dimensional structure. An entirely disordered polypeptide is known as an intrinsically disordered protein (IDP), and a segment of a protein that devoids a stable three-dimensional structure is called an intrinsically disordered region (IDR). It is increasingly recognized that…
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an abnormal CAG trinucleotide expansion within the first exon of the huntingtin gene. Specifically, pathological expansions above a critical CAG-repeat length of about 37 lead to the expression of a mutant huntingtin (mhtt) protein with an expanded polyglutamine (polyQ) domain, which ultimately forms amyloid-li…
The MSDP (Modified Scattering Density Profile) method for the analysis of Small-Angle X-ray Scattering (SAXS) experimental data of self-assembling systems, present in the GENFIT software in planar, cylindrical and spherical geometries, will be integrated by a database of the more common chemical groups constituting lipids and surfactants molecules. A knowledge transfer will be carried out…
(Only some records are available in English at this moment)
This PhD project aims to investigate the structure and function of disordered proteins in the cellular context, characterizing them in solution and examining their interaction with phospholipid bilayers that simulate the plasma membrane and other organelles. To this end, advanced and consolidated techniques for the study of nanostructures will be used, including low angle scattering (SAS)…
The Scatter Density Profile (MSDP) Method will be used to simulate and analyze SAXS curves of symmetrical and asymmetrical model membranes (lipid bilayers), composed of different lipids including POPC, DOPC, sphingomyelin, cholesterol, POPE, POPS, simulating plasma membranes, and BMP simulating lysosomal membranes. For this, a database of chemical groups constituting the different lipids …
Supramolecular structures constructed by the self-assembly of biomolecules are of special interest in a range of areas, including bio nanotechnology and nanomedicine. The nucleobase guanosine and its derivatives form tetramers linked by Hoogsteen-type hydrogen bonds, in presence of cation as Na+ and K+. These tetramers, called G-quartets stack on top of one another to form elongated stru…
(Only some records are available in English at this moment)
The Scattering Density Profile (MSDP) method will be used to simulate SAXS and SANS curves of symmetrical and asymmetrical model membranes (lipid bilayers) with respect to the lipid composition of the inner and outer membranes.Different lipid compositions will be investigated by simulating plasma membranes and extending to organelle membranes.This internship will be carried out at Prof. F…
The oxidative stress cause the lipid peroxidation that cause damage in the membrane and triggers signal cascades inducing apoptosis. The aim of this project is study the role of lipid hydroperoxide and the lipid raft formation. The studies will be performed in binary and ternary mixtures of lipids in presence of oxidized lipids. The informations about domain formation and membrane propert…
With this project of post-doctorate abroad (BEPE) we intend to enhance and develop the study of photo protection of model membranes, in follow-up to the project being implemented by post-doctorate Omar Mertins. The work done so far has shown an effective protection of lipid membranes with the use of gallic acid in the dispersion medium of giant vesicles. Quantitative studies allowed us to…
| 2 / 2 | Ongoing grants |
| 24 / 21 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 22 / 13 | Completed scholarships in Brazil |
| 6 / 3 | Completed scholarships abroad |
| 55 / 40 | All research grants and scholarships |
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