bachelor's at Fisica from Pontifícia Universidade Católica de São Paulo (1982), master's at Physic from Universidade de São Paulo (1986) and doctorate at Physic from Universidade de São Paulo (1991). Full Professor at USP, has experience on Physics, focusing on Liquids and Solids Structure; crystallography, acting on the following subjects: saxs, model membranes, photodynamic therapy, protein-protein interaction and protein-lipid interaction. Nowadays, President of the Brazilian Biophysical Society and member of SAXS committee from synchrotron Elettra, Italy. (Source: Lattes Curriculum)
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The MSDP (Modified Scattering Density Profile) method for the analysis of Small-Angle X-ray Scattering (SAXS) experimental data of self-assembling systems, present in the GENFIT software in planar, cylindrical and spherical geometries, will be integrated by a database of the more common chemical groups constituting lipids and surfactants molecules. A knowledge transfer will be carried out…
In last few years, Kinoshita's (University of Southern Denmark - SDU) and Dr. Rosangela Itri's (University of São Paulo - USP) groups have been investigating the effect of photosensitizer-mediated oxidative stress of porphyrin in the red blood cell (RBC) membrane. Through scientific visits of both groups and by setting a micropipette manipulation system at IFUSP, RBC project developed qui…
Considering the previous studies on pterin derivatives, carried out as a cooperation project between the Argentinean and Brazilian groups, this project is aimed to expand the study of lipophilic type I photosensitizers to new compounds derived from lumazine. In this way, the alkyllumazines, recently synthesized by the Argentinean group, will be here investigated according to the following…
(Only some records are available in English at this moment)
The Scatter Density Profile (MSDP) Method will be used to simulate and analyze SAXS curves of symmetrical and asymmetrical model membranes (lipid bilayers), composed of different lipids including POPC, DOPC, sphingomyelin, cholesterol, POPE, POPS, simulating plasma membranes, and BMP simulating lysosomal membranes. For this, a database of chemical groups constituting the different lipids …
Supramolecular structures constructed by the self-assembly of biomolecules are of special interest in a range of areas, including bio nanotechnology and nanomedicine. The nucleobase guanosine and its derivatives form tetramers linked by Hoogsteen-type hydrogen bonds, in presence of cation as Na+ and K+. These tetramers, called G-quartets stack on top of one another to form elongated stru…
Generating reactive oxygen species (ROS) in specific intracellular targets is the best strategy to maximize the Photodynamic Therapy (PDT) efficiency, since the short lifetime and high reactivity limited the ROS distribution inside cells. During years literature indicated mitochondria as target-organelle for PDT, however reports more recents indicate lysosomes as organelle-key to enhanced…
Studying photosensitized oxidation of unsaturated phospholipids is of importance for understanding the basic processes underlying photodynamic therapy, photoaging and many other biological disfunctions. In this project we will use large unilamellar vesicles as simplified models of biological membranes, to investigate how in situ photogenerated oxidative species impart on the phospholipid …
(Only some records are available in English at this moment)
The oxidative stress cause the lipid peroxidation that cause damage in the membrane and triggers signal cascades inducing apoptosis. The aim of this project is study the role of lipid hydroperoxide and the lipid raft formation. The studies will be performed in binary and ternary mixtures of lipids in presence of oxidized lipids. The informations about domain formation and membrane propert…
With this project of post-doctorate abroad (BEPE) we intend to enhance and develop the study of photo protection of model membranes, in follow-up to the project being implemented by post-doctorate Omar Mertins. The work done so far has shown an effective protection of lipid membranes with the use of gallic acid in the dispersion medium of giant vesicles. Quantitative studies allowed us to…
| 22 / 19 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 11 | Completed scholarships in Brazil |
| 5 / 2 | Completed scholarships abroad |
| 48 / 33 | All research grants and scholarships |
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CV Lattes
ORCID