Graduated in Dentistry from UNICAMP, holds a Masters degree in Cariology from UNICAMP, a PhD in Microbiology and Immunology from UNICAMP with a sandwich internship at the Forsyth Institute (Boston, USA), and a postdoctoral degree in Immunopharmacology from the Ribeirão Preto Medical School - USP. He has been a CNPq Research Productivity Fellow Level 2 since 2011. Since 2011, he has served as the Director of Postgraduate and Research at São Leopoldo Mandic College, the coordinator of the Professional Masters Program in Dentistry (2011 to present), and the PhD Program in Dental Sciences (2011 to 2019). He was an evaluator of Dentistry undergraduate programs for the Brazilian Ministry of Education (MEC) from 2007 to 2017. Elected as a member of the Advisory Council of SBPqO (2013-2015; 2015-2017; 2017-2019). Winner of the E.H. Hatton Scientific Award (2005 and 2018) granted by the Brazilian division (SBPqO) of the International Association for Dental Research (IADR). Representative of the private higher education institutions segment in the Forum of Pro-Rectors of Postgraduate Studies and Research (FOPROP) from 2018 to 2020, and Southeast regional representative in 2021. Named in the ranking published by the journal *Plos Biology* in 2020 as one of the 100,000 scientists with the most influential careers worldwide. Listed among the top 2 of the most influential scientists in the world in the Elsevier/Stanford 2024 ranking. (Source: Lattes Curriculum)
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Our research group has recently concluded the Thematic Research Grant (#17/22334-9), in which, through various published articles, we demonstrated that the inhibition of the soluble epoxide hydrolase (sEH) enzyme has anti-inflammatory effects, thereby hindering the progression of inflammatory osteolytic diseases. sEH inhibition was able to increase the systemic production of Specialized P…
Use of technical reserve funds to purchase equipment for 3 laboratories of the institution and for the Vivarium. (AU)
This project proposes the use of two drug release systems, the polymer nanoparticles and the microneedles patch, for the development and applicability of two formulations with immunomodulatory and neuroprotective potential. Epoxy-eicosatrienoic acid (EET) is a product of arachidonic acid metabolism catalyzed by cytochrome P450 epoxygenases. These small molecules are lipid mediators, which…
This project deals with the institutional technical reserve of FAPESP provided to SLMandic. (AU)
(Only some records are available in English at this moment)
The microneedles-coated is as a promising therapeutic proposal for the release of drugs in the control of inflammatory pain. Developed by Dr. Harvinder Singh Gill, Micro-Nano Medicine Immuno-Engineering Laboratory of the Texas Institute of Technology, Texas Tech University (Lubbock, USA), the microneedle patch contains 57 micro-needles (700 ¼m) allowing the transport of proteins troghout…
Recently the mucoadhesive systems for drug delivery have been highlighted due to the direction and more specific retention of the drug incorporated into the system. These formulations when combined with nanotechnology enable the control of drug release, and are used as a strategy to increase the bioavailability. The buccal route for drug delivery has shown to be very attractive as the maj…
Recently pharmacological agonists of Peroxisome Proliferator-Activated Receptor (PPAR-gama) and its natural agonist 15d- prostaglandin J2 (15d- PGJ2) are showing excellent results in experimental inflammatory models such as pancreatitis, sepsis and rheumatoid arthritis , and also its potent analgesic action. The 15d- PGJ2 has anti -inflammatory properties and have been reported to mediate…
(Only some records are available in English at this moment)
Specialized Pro-resolving lipid Mediators (SPMs) are metabolites of polyunsaturated fatty acids (PUFA), including arachidonic acid (AA) and the omega-3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This class of lipid mediators possesses physiological activity that limits the onset of inflammation and actively resolves chronic inflammation through binding to specific re…
| 1 / 1 | Ongoing grants |
| 11 / 11 | Completed research grants |
| 7 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 20 / 17 | All research grants and scholarships |
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CV Lattes
ORCID