CV Lattes
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ORCID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Enfermagem from Universidade de São Paulo (1983), master's at Bioquímica from Faculdade de Medicina de Ribeirão Preto (1987) and doctorate at Bioquímica from Faculdade de Medicina de Ribeirão Preto (1992). Has experience in Morphology, acting on the following subjects: melanoma, miosina-va, myosin-v, myosin-va and miosina-v. (Source: Lattes Curriculum)
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Long non-coding RNAs (lncRNAs) constitute a large and diverse class of functional RNAs. We identified the lncRNA RMEL3 as an enriched transcript in melanoma, particularly in those carrying the BRAFV600E mutation and with a markedly invasive phenotype. The data indicate that RMEL3 functions as a positive regulator of the MAPK and PI3K pathways and a negative regulator of cell cycle inhibit…
RMEL genes, first described by our group in 2010, are potential lncRNAs with expression restricted to melanoma. High expression of RMELs 2, 3 and 4 (HCCAT5) is associated with the presence of BRAFV600E, the major driver mutation of tumorigenesis in melanoma and other cancers. Ongoing research in our laboratory demonstrates that RMEL3 is a target of MAPK and PI3K pathways, and the transcri…
Papillary Thyroid Cancer (PTC) is an endocrine malignancy in which BRAFV600E oncogenic mutation induces the most aggressive phenotype. In this way, considering that lncRNAs are arising as key players in oncogenesis, it is of high interest the identification of BRAFV600E-associated long noncoding RNAs, which can provide possible candidates for secondary mechanisms of BRAF-induced malignanc…
Previous work identified RMEL3 as a lncRNA with enriched expression in melanoma. Analysis of The Cancer Genome Atlas (TCGA) data confirmed RMEL3 enriched expression in melanoma and demonstrated its association with the presence of BRAFV600E. RMEL3 siRNA-mediated silencing markedly reduced (95%) colony formation in different BRAFV600E melanoma cell lines. Multiple genes of the MAPK and PI3…
(Only some records are available in English at this moment)
RAS proteins are small GTPases that regulate a number of signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway. To perform this function, RAS proteins must associate with the plasma membrane. All RAS isoforms (HRAS, NRAS and, KRAS) are post-translationally modified at a C-terminal CaaX motif to gain affinity for cell membranes. Prominent among these post-transl…
Long non-coding RNAs (lncRNA) constitute a class of RNAs with function in the regulation of gene expression and cell signaling. Several lncRNAs play roles in cancer and one of them, RMEL3 (Restricted to Melanoma 3), was identified by our laboratory in melanoma, a cancer originated from melanocytes, pigment cells of the skin. RMEL3 is overexpressed in melanomas carrying the BRAFV600E mutat…
(Only some records are available in English at this moment)
Twelve years ago, genetic and biochemical interaction studies revealed an abundant and evolutionarily conserved protein complex that resides in the endoplasmic reticulum membrane (ER) and was named ER membrane protein complex (EMC). More recent studies suggest a role for EMC during membrane protein biogenesis. Biochemical reconstitution experiments show that EMC can directly mediate the i…
The endoplasmic reticulum is an essential organelle for the functioning of the eukaryotic cell. It is responsible for various processes, such as protein synthesis, folding and post-translational modification. Although most of these cellular processes are well known, there are many proteins identified or predicted in important cell pathways that remain uncharacterized. The transmembrane pr…
Mitochondrial architecture is involved in several crucial functions for cell viability, as proliferation, senescence and signaling. Mutations that affect these processes are common causes of neurologic, muscular and metabolic disorders and cancer. In particular, the mitochondrial dynamics through the balance between fusion and fission, and the mitophagy to remove damaged mitochondria, pla…
(Only some records are available in English at this moment)
The RAS proteins are small GTPases that regulate a number of signaling pathways including the mitogen-activated protein kinase (MAPK) pathway. To perform this function, RAS proteins must associate with the plasma membrane (PM). All RAS isoforms (HRAS, NRAS and, KRAS) are post-translational modified at a C-terminal CaaX motif to gain affinity for cellular membranes. Prenylation (lipidation…
Mitochondrial morphology and quality control are dependent on the mitochondrial fission and fusion dynamics, which requires dynamin-like GTPases, coordinated activity of mitochondria- ER contact sites and the actin cytoskeleton, along with actin regulatory proteins and molecular motors. Impairment of the balance between fission and fusion results in aging, neurodegenerative diseases and t…
Melanoma is the most aggressive form of skin cancer. Targeted therapies against BRAFV600 mutations, which are present in ~60% of melanomas, achieve impressive initial clinical responses, but the development of acquired resistance to these agents is almost universal. The identification of additional melanoma oncogenic mechanisms initiated by oncogenic BRAF will facilitate the development o…
Focal adhesion turnover is crucial for cell migration. Through this process, focal complexes disassemble and their components reassemble into new focal contacts. Focal adhesion disassembly occurs through clathrin-dependent endocytosis of integrin and also requires microtubule and FAK. Endocytosed integrins entering early endosomal vesicles (Rab5) end up eventually to late endosomes, but m…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 15 / 10 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 41 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 67 / 36 | All research grants and scholarships |
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