bachelor's at medicina from FACULDADE DE MEDICINA DO TRIANGULO MINEIRO (1979), master's at Clínica Médica from Universidade de São Paulo (1985) and doctorate at Clínica Médica from Universidade de São Paulo (1988). He is currently full professor at Universidade Estadual de Campinas. Has experience in Medicine, focusing on Endocrinology, acting on the following subjects: insulina, insulin, insulinica, resistencia a insulina and diabetes. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| The mystery behind diabetes |
| Una trama que subyace en la diabetes |
| Visceral connections |
| Conexiones viscerales |
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| News published in Agência FAPESP Newsletter about the researcher |
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| Articles published in other media outlets ( ): |
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| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Obesity is characterized by a chronic low-grade inflammation in body tissues, especially in adipose tissue, where there is an increase in the release of inflammatory mediators, capable of interfering with the insulin signaling pathway, impairing the intracellular transport of glucose and establishing the Insulin Resistance (IR), which can later evolve into Type 2 Diabetes Mellitus, when t…
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas t…
The Faculty of Medical Sciences (FCM), State University of Campinas (UNICAMP) comprises one of the units of teaching and research at Unicamp consists of four graduate and nine Postgraduate programs which operate over 2500 students. Over the last 10 years an average of 700 scientific papers per year, indexed in Science Citation Index in its more than 100 research laboratories spread over a…
(Only some records are available in English at this moment)
Obesity is characterized by chronic low-grade inflammation that increases the release of inflammatory mediators, impairing insulin signaling and potentially triggering insulin resistance (IR). Due to the inability to produce insulin in the pancreas or the inefficiency in effective insulin use to control hyperglycemia, IR can progress to Type 2 Diabetes Mellitus (DMT2). The prevalence of o…
Obesity is characterized by a chronic low-grade inflammation in body tissues, especially in adipose tissue, where there is an increase in the release of inflammatory mediators, capable of interfering with the insulin signaling pathway, impairing the intracellular transport of glucose and establishing the Insulin Resistance (IR), which can later evolve into Type 2 Diabetes Mellitus, when t…
MicroRNAs are small non-coding RNAs that can regulate gene expression by inhibiting translation or promoting mRNA degradation. miRNAs can be released into the circulation where they are carried by ribonucleoproteins, such as Agonaute-2, or lipoproteins, like HDL, or in extracellular vesicles or exosomes. Studies have shown an advantage of exosomes over artificial liposomes for RNA transpo…
The increase in obesity in the national and world panorama is of great importance to public health, because it is closely associated with the development of chronic diseases, mainly diabetes mellitus type 2 (DM2). Obesity causes a state of chronic inflammation, triggered by the white adipose tissue (WAT) and their resident macrophages. Excess free fatty acids, LPS and inflammatory cytokin…
Obesity is a consequence of factors such as over nutrition and sedentary lifestyle, which leads to weight gain and several metabolic disorders, especially Insulin Resistance (IR) and Type II Diabetes (DM2). Several intracellular mechanisms are associated with the IR emergence, among them, is the iNOS enzyme, which activity is induced by pro-inflammatory cytokines in obesity. Many studies …
(Only some records are available in English at this moment)
MicroRNAs are small non-coding RNAs that can regulate gene expression being released into the circulation where they are carried by ribonucleoproteins, lipoproteins, extracellular vesicles or exosomes. Studies have shown an advantage of exosomes over artificial liposomes for RNA transport due to their higher capacity of endocytosis and protection against phagocytosis. In addition, althoug…
Obesity has become a worldwide pandemic and is characterized by an energy imbalance in favor of the energy accumulation by white adipose tissue (WAT). Obesity is a risk factor for several diseases. The main role of WAT is to accumulate energy as fat, on the other hand, the brown adipose tissue (BAT) contributes to the energy expenditure by heat production. The activation of the thermogeni…
Obesity, a disease characterized by low-grade chronic inflammation in adipose tissue, results from the disturbance of the body's energy balance, induced by factors such as overnutrition and sedentary lifestyle, leading to weight gain and metabolic disorders. Several intracellular pathways are associated with Insulin Resistance (IR) occurrence and, among them, it's the iNOS enzyme, which i…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 31 / 16 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 79 / 24 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 121 / 51 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID