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Rosario Dominguez Crespo Hirata

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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF)  (Institutional affiliation for the last research proposal)
Birthplace: Espanha

Rosario Dominguez Crespo Hirata is a retired professor at the School of Pharmaceutical Sciences at the University of Sao Paulo (FCF/USP), Brazil. She is a pharmacist, has MSc and PhD from the University of Sao Paulo, and a postdoctoral fellow at the US Food and Drug Administration, USA. Prof. Rosario is currently advisor to the Graduate Program in Pharmacy - Pathophysiology and Toxicology at FCF/USP. Prof. Rosario investigates the molecular basis of metabolic, cardiovascular and renal diseases using genomic, pharmacogenomic and epigenomic approaches. Its research group contributes to the scientific knowledge in pharmacogenomics of lipid-lowering and immunosuppressive drugs, producing innovative data on the Brazilian population. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated June 12, 2021
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (37)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications31
Citations293
Cit./Article9.5
Data from Web of Science

ZHOU, YITIAN; DAGLI HERNANDEZ, CAROLINA; LAUSCHKE, VOLKER M.. Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier. BRITISH JOURNAL OF CANCER, v. 123, n. 12, p. 1782-1789, . Web of Science Citations: 0. (19/19009-4)

COSTA DE FREITAS, RENATA CAROLINE; BORTOLIN, RAUL HERNANDES; VECCHIA GENVIGIR, FABIANA DALLA; BONEZI, VIVIAN; CRESPO HIRATA, THIAGO DOMINGUEZ; FELIPE, CLAUDIA ROSSO; TEDESCO-SILVA, JR., HELIO; MEDINA-PESTANA, JOSE OSMAR; CERDA, ALVARO; DOI, SONIA QUATELI; et al. Differentially expressed urinary exo-miRs and clinical outcomes in kidney recipients on short-term tacrolimus therapy: a pilot study. Epigenomics, v. 12, n. 22, . Web of Science Citations: 0. (16/13118-8)

HINUY, HAMILTON M.; HIRATA, MARIO H.; SAMPAIO, MARCELO F.; ARMAGANIJAN, DIKRAN; ARAZI, SIMONE SORKIN; SALAZAR, LUIS A.; HIRATA, ROSARIO D. C.. Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 54, n. 3, p. 282-288, . Web of Science Citations: 17. (06/04994-7)

HINUY, HAMILTON M.; ARAZI, SIMONE S.; HIRATA, MARIO H.; SAMPAIO, MARCELO F.; ARMAGANIJAN, DIKRAN; CAVALLI, SELMA A.; HIRATA, ROSARIO D. C.. Relationship of short tandem repeats flanking leptin-melanocortin pathway genes with anthropometric profile and leptinemia in Brazilian individuals. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 1, p. 47-53, . Web of Science Citations: 1.

CERDA, ALVARO; ISSA, MUSTAFA H.; GENVIGIR, FABIANA D. V.; ROHDE, CINTIA B.; CAVALLI, SELMA A.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; HIRATA, MARIO H.; HIRATA, ROSARIO D. C.. Atorvastatin and hormone therapy influence expression of ABCA1, APOA1 and SCARB1 in mononuclear cells from hypercholesterolemic postmenopausal women. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, v. 138, p. 403-409, . Web of Science Citations: 7. (09/15125-8)

RODRIGUES, A. C.; SOBRINO, B.; GENVIGIR, F. D. V.; WILLRICH, M. A. V.; ARAZI, S. S.; DOREA, E. L.; BERNIK, M. M. S.; BERTOLAMI, M.; FALUDI, A. A.; BRION, M. J.; et al. Genetic variants in genes related to lipid metabolism and atherosclerosis, dyslipidemia and atorvastatin response. Clinica Chimica Acta, v. 417, p. 8-11, . Web of Science Citations: 19. (08/06667-9)

K.B. MASSIRER; M.H. HIRATA; A.E.B. SILVA; M.L.G. FERRAZ; N.Y. NGUYEN; R.D.C. HIRATA. Interferon-alpha receptor 1 mRNA expression in peripheral blood mononuclear cells is associated with response to interferon-alpha therapy of patients with chronic hepatitis C. Brazilian Journal of Medical and Biological Research, v. 37, n. 5, p. 643-647, .

CERDA, ALVARO; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; HIRATA, MARIO H.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; HIRATA, ROSARIO D. C.. Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. Clinica Chimica Acta, v. 411, n. 9-10, p. 631-637, . Web of Science Citations: 19. (06/06196-0)

DE OLIVEIRA, RAQUEL; MORAES, TAMIRIS INVENCIONI; CERDA, ALVARO; HIRATA, MARIO HIROYUKI; FAJARDO, CRISTINA MORENO; SOUSA, MARCELA CORREIA; DOREA, EGIDIO LIMA; SILVEIRA BERNIK, MYRCIA MARTINS; CRESPO HIRATA, ROSARIO DOMINGUEZ. ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction. DIABETOLOGY & METABOLIC SYNDROME, v. 7, . Web of Science Citations: 2. (09/10069-2)

DE OLIVEIRA, RAQUEL; CERDA, ALVARO; GENVIGIR, FABIANA DALLA VECCHIA; FERRAZ SAMPAIO, MARCELO; ARMAGANIJAN, DIKRAN; SILVEIRA BERNIK, MARCIA MARTINS; DOREA, EGIDIO LIMA; HIRATA, MARIO HIROYUKI; HINUY, HAMILTON MASSAYUKI; CRESPO HIRATA, ROSARIO DOMINGUEZ. Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 57, n. 9, p. 677-684, . Web of Science Citations: 4. (09/10069-2)

GENVIGIR‚ F.D.V.; HIRATA‚ M.H.; HIRATA‚ R.D.C.. ABCA1 expression and statins: inhibitory effect in peripheral blood mononuclear cells. PHARMACOGENOMICS, v. 10, n. 6, p. 997-1005, . (07/00398-3)

RODRIGUES‚ A.C.; HIRATA‚ M.H.; HIRATA‚ R.D.C.. Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs. PHARMACOGENOMICS, v. 10, n. 6, p. 1007-1016, . (08/01465-9)

ZAMBRANO, TOMAS; HIRATA, ROSARIO D. C.; HIRATA, MARIO H.; CERDA, ALVARO; SALAZAR, LUIS A.. Statins differentially modulate microRNAs expression in peripheral cells of hyperlipidemic subjects: A pilot study. European Journal of Pharmaceutical Sciences, v. 117, p. 55-61, . Web of Science Citations: 3. (11/21967-1)

FORESTIERO, FRANCISCO JOSE; CECON, LETICIA; HIRATA, MARIO HIROUKI; DE MELO, FERNANDO FIUZA; CARDOSO, ROSILENE FRESSATTI; CERDA, ALVARO; CRESPO HIRATA, ROSARIO DOMINGUEZ. Relationship of NAT2, CYP2E1 and GSTM1/GSTT1 polymorphisms with mild elevation of liver enzymes in Brazilian individuals under anti-tuberculosis drug therapy. Clinica Chimica Acta, v. 415, p. 215-219, . Web of Science Citations: 8.

SALAZAR‚ L.A.; HIRATA‚ M.H.; GIANNINI‚ S.D.; FORTI‚ N.; DIAMENT‚ J.; LIMA‚ T.M.; HIRATA‚ R.D.C.. Seven DNA polymorphisms at the candidate genes of atherosclerosis in Brazilian women with angiographically documented coronary artery disease. Clinica Chimica Acta, v. 300, n. 1, p. 139-149, .

GENVIGIR, FABIANA D. V.; SALGADO, PATRICIA C.; FELIPE, CLAUDIA R.; LUO, ELENA Y. F.; ALVES, CAMILA; CERDA, ALVARO; TEDESCO-SILVA, JR., HELIO; MEDINA-PESTANA, JOSE O.; OLIVEIRA, NAGILLA; RODRIGUES, ALICE C.; et al. Influence of the CYP3A4/5 genetic score and ABCB1 polymorphisms on tacrolimus exposure and renal function in Brazilian kidney transplant patients. PHARMACOGENETICS AND GENOMICS, v. 26, n. 10, p. 462-472, . Web of Science Citations: 17. (11/10039-6)

SALGADO, PATRICIA C.; GENVIGIR, FABIANA D. V.; FELIPE, CLAUDIA R.; TEDESCO-SILVA, JR., HELIO; MEDINA-PESTANA, JOSE O.; DOI, SONIA Q.; HIRATA, MARIO H.; HIRATA, ROSARIO D. C.. Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients. PHARMACOGENOMICS & PERSONALIZED MEDICINE, v. 10, p. 101-105, . Web of Science Citations: 3. (11/10039-6)

BRAYAN CAMPOS-SALAZAR, ANTONY; GENVIGIR, FABIANA DALLA VECCHIA; FELIPE, CLAUDIA ROSSO; TEDESCO-SILVA, HELIO; MEDINA-PESTANA, JOSE; MONTEIRO, GABRIELA VIEIRA; BASSO, RODRIGO DE GOUVEIA; CERDA, ALVARO; HIRATA, MARIO HIROYUKI; CRESPO HIRATA, ROSARIO DOMINGUEZ. Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients. FRONTIERS IN PHARMACOLOGY, v. 9, . Web of Science Citations: 1. (16/13118-8)

GENVIGIR, FABIANA DALLA VECCHIA; BRAYAN CAMPOS-SALAZAR, ANTONY; FELIPE, CLAUDIA ROSSO; TEDESCO-SILVA JR, HELIO; MEDINA-PESTANA, JOSE OSMAR; DOI, SONIA DE QUATELI; CERDA, ALVARO; HIRATA, MARIO HIROYUKI; HERRERO, MARIA JOSE; ALINO, SALVADOR FRANCISCO; et al. CYP3A5{*}3 and CYP2C8{*}3 variants influence exposure and clinical outcomes of tacrolimus-based therapy. PHARMACOGENOMICS, v. 21, n. 1, p. 7-21, . Web of Science Citations: 0. (16/13118-8)

CERDA, ALVARO; GENVIGIR, FABIANA DALLA VECCHIA; RODRIGUES, ALICE CRISTINA; VIEIRA WILLRICH, MARIA ALICE; DOREA, EGIDIO LIMA; SILVEIRA BERNIK, MARCIA MARTINS; ARAZI, SIMONE SORKIN; DE OLIVEIRA, RAQUEL; HIRATA, MARIO HIROYUKI; CRESPO HIRATA, ROSARIO DOMINGUEZ. Influence of Polymorphisms and Cholesterol-Lowering Treatment on SCARB1 mRNA Expression. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, v. 18, n. 8, p. 640-651, . Web of Science Citations: 9. (09/15125-8)

RODRIGUES‚ A.C.; HIRATA‚ M.H.; HIRATA‚ R.D.C.. Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs. PHARMACOGENOMICS, v. 10, n. 6, p. 1007-1016, . (08/01465-9)

ZHOU, YITIAN; DAGLI HERNANDEZ, CAROLINA; LAUSCHKE, VOLKER M.. Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier. BRITISH JOURNAL OF CANCER, v. 123, n. 12, p. 1782-1789, . Web of Science Citations: 0. (19/19009-4)

GENVIGIR, FABIANA DALLA VECCFHIA; RODRIGUES, ALICE CRISTINA; CERDA, ALVARO; ARAZI, SIMONE SORKIN; VIEIRA WILLRICH, MARIA ALICE; OLIVEIRA, RAQUEL; HIRATA, MARIO HIROYUKI; DOREA, EGIDIO LIMA; BERNIK, MARCIA MARTINS; CURI, RUI; et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. PHARMACOGENOMICS, v. 11, n. 9, p. 1235-1246, . Web of Science Citations: 16. (06/06196-0, 09/15125-8)

SILBIGER, VIVIAN N.; HIRATA, MARIO H.; LUCHESSI, ANDRE D.; GENVIGIR, FABIANA D. V.; CERDA, ALVARO; RODRIGUES, ALICE C.; WILLRICH, MARIA A. V.; ARAZI, SIMONE S.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; et al. Differentiation of African Components of Ancestry to Stratify Groups in a Case-Control Study of a Brazilian Urban Population. GENETIC TESTING AND MOLECULAR BIOMARKERS, v. 16, n. 6, p. 524-530, . Web of Science Citations: 3.

MORETTI REBECCHI, IVANISE MARINA; RODRIGUES, ALICE CRISTINA; ARAZI, SIMONE SORKIN; GENUIGIR, FABIANA DALLA VECCHIA; VIEIRA WILLRICH, MARIA ALICE; HIRATA, MARIO HIROYUKI; SOARES, SARAH APARECIDA; BERTOLAMI, MARCELO CHIARA; FALUDI, ANDRE ARPAD; BERNIK, MARCIA MARTINS SILVEIRA; et al. ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. Biochemical Pharmacology, v. 77, n. 1, p. 66-75, . Web of Science Citations: 23.

CERDA, ALVARO; GENVIGIR, FABIANA D. V.; WILLRICH, MARIA A. V.; ARAZI, SIMONE S.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; HIRATA, MARIO H.; HIRATA, ROSARIO D. C.. Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin. LIPIDS IN HEALTH AND DISEASE, v. 10, . Web of Science Citations: 6. (09/15125-8)

WILLRICH, MARIA ALICE V.; HIRATA, MARIO H.; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; REBECCHI, IVANISE M. M.; RODRIGUES, ALICE C.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; et al. CYP3A5{*}3A allele is associated with reduced lowering-lipid response to atorvastatin in individuals with hypercholesterolemia. Clinica Chimica Acta, v. 398, n. 1-2, p. 15-20, . Web of Science Citations: 38.

GENVIGIR‚ F.D.V.; SOARES‚ S.A.; HIRATA‚ M.H.; WILLRICH‚ M.A.V.; ARAZI‚ S.S.; REBECCHI‚ I.M.M.; OLIVEIRA‚ R.; BERNIK‚ M.; DOREA‚ E.L.; BERTOLAMI‚ M.C.; et al. Effects of ABCA1 SNPs‚ including the C-105T novel variant‚ on serum lipids of Brazilian individuals. Clinica Chimica Acta, v. 389, n. 1-2, p. 79-86, .

CERDA, ALVARO; RODRIGUES, ALICE CRISTINA; ALVES, CAMILA; GENVIGIR, FABIANA DALLA VECCHIA; FAJARDO, CRISTINA MORENO; DOREA, EGIDIO LIMA; GUSUKUMA, MARIA CECILIA; PINTO, GELBA ALMEIDA; HIRATA, MARIO HIROYUKI; CRESPO HIRATA, ROSARIO DOMINGUEZ. Modulation of Adhesion Molecules by Cholesterol-Lowering Therapy in Mononuclear Cells from Hypercholesterolemic Patients. Cardiovascular Therapeutics, v. 33, n. 4, p. 168-176, . Web of Science Citations: 7. (10/15353-8)

ZAMBRANO, TOMAS; HIRATA, ROSARIO D. C.; HIRATA, MARIO H.; CERDA, ALVARO; SALAZAR, LUIS A.. Altered microRNome Profiling in Statin-Induced HepG2 Cells: A Pilot Study Identifying Potential new Biomarkers Involved in Lipid-Lowering Treatment. CARDIOVASCULAR DRUGS AND THERAPY, v. 29, n. 6, p. 509-518, . Web of Science Citations: 9. (11/21967-1)

ZAMBRANO, TOMAS; HIRATA, ROSARIO D. C.; HIRATA, MARIO H.; CERDA, ALVARO; SALAZAR, LUIS A.. Altered microRNome Profiling in Statin-Induced HepG2 Cells: A Pilot Study Identifying Potential new Biomarkers Involved in Lipid-Lowering Treatment. CARDIOVASCULAR DRUGS AND THERAPY, v. 29, n. 6, p. 509-518, . Web of Science Citations: 9. (11/21967-1)

WILLRICH, MARIA ALICE V.; RODRIGUES, ALICE C.; CERDA, ALVARO; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE; LARGURA, ALVARO; et al. Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients. Clinica Chimica Acta, v. 421, p. 157-163, . Web of Science Citations: 14. (08/06667-9)

A.C. RODRIGUES; I.M.M. REBECCHI; M.C. BERTOLAMI; A.A. FALUDI; M.H. HIRATA; R.D.C. HIRATA. High baseline serum total and LDL cholesterol levels are associated with MDR1 haplotypes in Brazilian hypercholesterolemic individuals of European descent. Brazilian Journal of Medical and Biological Research, v. 38, n. 9, p. 1389-1397, .

L.A. SALAZAR; S.A. CAVALLI; M.H. HIRATA; J. DIAMENT; N. FORTI; S.D. GIANNINI; E.R. NAKANDAKARE; M.C. BERTOLAMI; R.D.C. HIRATA. Polymorphisms of the low-density lipoprotein receptor gene in Brazilian individuals with heterozygous familial hypercholesterolemia. Brazilian Journal of Medical and Biological Research, v. 33, n. 11, p. 1301-1304, .

RODRIGUES, ALICE C.; PERIN, PAULA M. S.; PURIM, SHEILA G.; SILBIGER, VIVIAN N.; GENVIGIR, FABIANA D. V.; WILLRICH, MARIA ALICE V.; ARAZI, SIMONE S.; LUCHESSI, ANDRE D.; HIRATA, MARIO H.; BERNIK, MARCIA M. S.; et al. Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A > G Variant Is Determinant of Increased Atorvastatin Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 12, n. 9, p. 5815-5827, . Web of Science Citations: 40. (08/06667-9)

SALAZAR, LUIS A.; HIRATA, MARIO H.; CAVALLI, SELMA A.; NAKANDAKARE, EDNA R.; FORTI, NEUSA; DIAMENT, JAIME; GIANNINI, SERGIO D.; BERTOLAMI, MARCELO C.; HIRATA, ROSARIO D. C.. Molecular Basis of Familial Hypercholesterolemia in Brazil: Identification of Seven Novel LDLR Gene Mutations. Human mutation, v. 19, n. 4, p. 462-463, . Web of Science Citations: 16.

RODRIGUES, ALICE C.; NERI, ELIDA ADALGISA; VERISSIMO-FILHO, SIDNEY; REBOUCAS, NANCY AMARAL; HIRATA, ROSARIO D. C.; YU, AI-MING. Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells. European Journal of Pharmaceutical Sciences, v. 93, p. 431-436, . Web of Science Citations: 5. (11/05876-6, 08/01465-9)

CERDA, ALVARO; AMARAL, ADONAI ARALIM; DE OLIVEIRA, RAQUEL; MORAES, TAMIRIS INVENCIONI; BRAGA, AECIO ASSUNCAO; GRACIANO-SALDARRIAGA, MAGDA ELIZABETH; FAJARDO, CRISTINA MORENO; HIRATA, THIAGO DOMINGUEZ CRESPO; BONEZI, VIVIAN; CAMPOS-SALAZAR, ANTONY BRAYAN; et al. Peripheral Blood miRome Identified miR-155 as Potential Biomarker of MetS and Cardiometabolic Risk in Obese Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 3, . Web of Science Citations: 0. (09/10069-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

HINUY, Hamilton Massayuki. Avaliação de regiões hipervariáveis de genes que predispõem à obesidade.  126 f. Dissertação (Mestrado) -  Faculdade de Ciências Farmacêuticas.  Universidade de São Paulo (USP).  São Paulo.  (00/11700-3

RODRIGUES, Alice Cristina. Efeito da atorvastatina sobre a atividade funcional e expressão de transportadores de membrana do tipo ABC e SLC.  167 f. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas.  Universidade de São Paulo (USP).  São Paulo.  (05/60240-9

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