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Rosario Dominguez Crespo Hirata

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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF)  (Institutional affiliation for the last research proposal)
Birthplace: Espanha

Rosario Dominguez Crespo Hirata is a retired professor at the School of Pharmaceutical Sciences at the University of São Paulo, Brazil. She is a pharmacist, has MSc and PhD from the University of São Paulo, and a postdoctoral fellow at the US Food and Drug Administration, USA. Professor Hirata investigates the molecular basis of metabolic, cardiovascular and kidney diseases using genomic, epigenomic and pharmacogenomic approaches. Her research group contributes to scientific knowledge in pharmacogenomics of lipid-lowering and immunosuppressive drugs, producing innovative data on the Brazilian population. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated June 27, 2020
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (34)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications27
Citations293
Cit./Article10.9
Data from Web of Science

GENVIGIR‚ F.D.V.; SOARES‚ S.A.; HIRATA‚ M.H.; WILLRICH‚ M.A.V.; ARAZI‚ S.S.; REBECCHI‚ I.M.M.; OLIVEIRA‚ R.; BERNIK‚ M.; DOREA‚ E.L.; BERTOLAMI‚ M.C.; et al. Effects of ABCA1 SNPs‚ including the C-105T novel variant‚ on serum lipids of Brazilian individuals. Clinica Chimica Acta, v. 389, n. 1-2, p. 79-86, .

CERDA, ALVARO; GENVIGIR, FABIANA D. V.; WILLRICH, MARIA A. V.; ARAZI, SIMONE S.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; HIRATA, MARIO H.; HIRATA, ROSARIO D. C.. Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin. LIPIDS IN HEALTH AND DISEASE, v. 10, . Web of Science Citations: 6. (09/15125-8)

WILLRICH, MARIA ALICE V.; RODRIGUES, ALICE C.; CERDA, ALVARO; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE; LARGURA, ALVARO; et al. Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients. Clinica Chimica Acta, v. 421, p. 157-163, . Web of Science Citations: 14. (08/06667-9)

SILBIGER, VIVIAN N.; HIRATA, MARIO H.; LUCHESSI, ANDRE D.; GENVIGIR, FABIANA D. V.; CERDA, ALVARO; RODRIGUES, ALICE C.; WILLRICH, MARIA A. V.; ARAZI, SIMONE S.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; et al. Differentiation of African Components of Ancestry to Stratify Groups in a Case-Control Study of a Brazilian Urban Population. GENETIC TESTING AND MOLECULAR BIOMARKERS, v. 16, n. 6, p. 524-530, . Web of Science Citations: 3.

WILLRICH, MARIA ALICE V.; HIRATA, MARIO H.; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; REBECCHI, IVANISE M. M.; RODRIGUES, ALICE C.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; et al. CYP3A5{*}3A allele is associated with reduced lowering-lipid response to atorvastatin in individuals with hypercholesterolemia. Clinica Chimica Acta, v. 398, n. 1-2, p. 15-20, . Web of Science Citations: 38.

GENVIGIR, FABIANA DALLA VECCFHIA; RODRIGUES, ALICE CRISTINA; CERDA, ALVARO; ARAZI, SIMONE SORKIN; VIEIRA WILLRICH, MARIA ALICE; OLIVEIRA, RAQUEL; HIRATA, MARIO HIROYUKI; DOREA, EGIDIO LIMA; BERNIK, MARCIA MARTINS; CURI, RUI; et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. PHARMACOGENOMICS, v. 11, n. 9, p. 1235-1246, . Web of Science Citations: 16. (06/06196-0, 09/15125-8)

RODRIGUES, ALICE C.; PERIN, PAULA M. S.; PURIM, SHEILA G.; SILBIGER, VIVIAN N.; GENVIGIR, FABIANA D. V.; WILLRICH, MARIA ALICE V.; ARAZI, SIMONE S.; LUCHESSI, ANDRE D.; HIRATA, MARIO H.; BERNIK, MARCIA M. S.; et al. Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A > G Variant Is Determinant of Increased Atorvastatin Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 12, n. 9, p. 5815-5827, . Web of Science Citations: 40. (08/06667-9)

SALAZAR, LUIS A.; HIRATA, MARIO H.; CAVALLI, SELMA A.; NAKANDAKARE, EDNA R.; FORTI, NEUSA; DIAMENT, JAIME; GIANNINI, SERGIO D.; BERTOLAMI, MARCELO C.; HIRATA, ROSARIO D. C.. Molecular Basis of Familial Hypercholesterolemia in Brazil: Identification of Seven Novel LDLR Gene Mutations. Human mutation, v. 19, n. 4, p. 462-463, . Web of Science Citations: 16.

MORETTI REBECCHI, IVANISE MARINA; RODRIGUES, ALICE CRISTINA; ARAZI, SIMONE SORKIN; GENUIGIR, FABIANA DALLA VECCHIA; VIEIRA WILLRICH, MARIA ALICE; HIRATA, MARIO HIROYUKI; SOARES, SARAH APARECIDA; BERTOLAMI, MARCELO CHIARA; FALUDI, ANDRE ARPAD; BERNIK, MARCIA MARTINS SILVEIRA; et al. ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. Biochemical Pharmacology, v. 77, n. 1, p. 66-75, . Web of Science Citations: 23.

RODRIGUES, ALICE C.; NERI, ELIDA ADALGISA; VERISSIMO-FILHO, SIDNEY; REBOUCAS, NANCY AMARAL; HIRATA, ROSARIO D. C.; YU, AI-MING. Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells. European Journal of Pharmaceutical Sciences, v. 93, p. 431-436, . Web of Science Citations: 5. (08/01465-9, 11/05876-6)

ZAMBRANO, TOMAS; HIRATA, ROSARIO D. C.; HIRATA, MARIO H.; CERDA, ALVARO; SALAZAR, LUIS A.. Altered microRNome Profiling in Statin-Induced HepG2 Cells: A Pilot Study Identifying Potential new Biomarkers Involved in Lipid-Lowering Treatment. CARDIOVASCULAR DRUGS AND THERAPY, v. 29, n. 6, p. 509-518, . Web of Science Citations: 9. (11/21967-1)

CERDA, ALVARO; RODRIGUES, ALICE CRISTINA; ALVES, CAMILA; GENVIGIR, FABIANA DALLA VECCHIA; FAJARDO, CRISTINA MORENO; DOREA, EGIDIO LIMA; GUSUKUMA, MARIA CECILIA; PINTO, GELBA ALMEIDA; HIRATA, MARIO HIROYUKI; CRESPO HIRATA, ROSARIO DOMINGUEZ. Modulation of Adhesion Molecules by Cholesterol-Lowering Therapy in Mononuclear Cells from Hypercholesterolemic Patients. Cardiovascular Therapeutics, v. 33, n. 4, p. 168-176, . Web of Science Citations: 7. (10/15353-8)

A.C. RODRIGUES; I.M.M. REBECCHI; M.C. BERTOLAMI; A.A. FALUDI; M.H. HIRATA; R.D.C. HIRATA. High baseline serum total and LDL cholesterol levels are associated with MDR1 haplotypes in Brazilian hypercholesterolemic individuals of European descent. Brazilian Journal of Medical and Biological Research, v. 38, n. 9, p. 1389-1397, .

L.A. SALAZAR; S.A. CAVALLI; M.H. HIRATA; J. DIAMENT; N. FORTI; S.D. GIANNINI; E.R. NAKANDAKARE; M.C. BERTOLAMI; R.D.C. HIRATA. Polymorphisms of the low-density lipoprotein receptor gene in Brazilian individuals with heterozygous familial hypercholesterolemia. Brazilian Journal of Medical and Biological Research, v. 33, n. 11, p. 1301-1304, .

SALAZAR‚ L.A.; HIRATA‚ M.H.; GIANNINI‚ S.D.; FORTI‚ N.; DIAMENT‚ J.; LIMA‚ T.M.; HIRATA‚ R.D.C.. Seven DNA polymorphisms at the candidate genes of atherosclerosis in Brazilian women with angiographically documented coronary artery disease. Clinica Chimica Acta, v. 300, n. 1, p. 139-149, .

GENVIGIR‚ F.D.V.; HIRATA‚ M.H.; HIRATA‚ R.D.C.. ABCA1 expression and statins: inhibitory effect in peripheral blood mononuclear cells. PHARMACOGENOMICS, v. 10, n. 6, p. 997-1005, . (07/00398-3)

RODRIGUES‚ A.C.; HIRATA‚ M.H.; HIRATA‚ R.D.C.. Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs. PHARMACOGENOMICS, v. 10, n. 6, p. 1007-1016, . (08/01465-9)

CERDA, ALVARO; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; HIRATA, MARIO H.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; HIRATA, ROSARIO D. C.. Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. Clinica Chimica Acta, v. 411, n. 9-10, p. 631-637, . Web of Science Citations: 19. (06/06196-0)

BRAYAN CAMPOS-SALAZAR, ANTONY; GENVIGIR, FABIANA DALLA VECCHIA; FELIPE, CLAUDIA ROSSO; TEDESCO-SILVA, HELIO; MEDINA-PESTANA, JOSE; MONTEIRO, GABRIELA VIEIRA; BASSO, RODRIGO DE GOUVEIA; CERDA, ALVARO; HIRATA, MARIO HIROYUKI; CRESPO HIRATA, ROSARIO DOMINGUEZ. Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients. FRONTIERS IN PHARMACOLOGY, v. 9, . Web of Science Citations: 1. (16/13118-8)

GENVIGIR, FABIANA DALLA VECCHIA; BRAYAN CAMPOS-SALAZAR, ANTONY; FELIPE, CLAUDIA ROSSO; TEDESCO-SILVA JR, HELIO; MEDINA-PESTANA, JOSE OSMAR; DOI, SONIA DE QUATELI; CERDA, ALVARO; HIRATA, MARIO HIROYUKI; HERRERO, MARIA JOSE; ALINO, SALVADOR FRANCISCO; et al. CYP3A5{*}3 and CYP2C8{*}3 variants influence exposure and clinical outcomes of tacrolimus-based therapy. PHARMACOGENOMICS, v. 21, n. 1, p. 7-21, . Web of Science Citations: 0. (16/13118-8)

GENVIGIR‚ F.D.V.; SOARES‚ S.A.; HIRATA‚ M.H.; WILLRICH‚ M.A.V.; ARAZI‚ S.S.; REBECCHI‚ I.M.M.; OLIVEIRA‚ R.; BERNIK‚ M.; DOREA‚ E.L.; BERTOLAMI‚ M.C.; et al. Effects of ABCA1 SNPs‚ including the C-105T novel variant‚ on serum lipids of Brazilian individuals. Clinica Chimica Acta, v. 389, n. 1-2, p. 79-86, .

CERDA, ALVARO; GENVIGIR, FABIANA D. V.; WILLRICH, MARIA A. V.; ARAZI, SIMONE S.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; HIRATA, MARIO H.; HIRATA, ROSARIO D. C.. Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin. LIPIDS IN HEALTH AND DISEASE, v. 10, . Web of Science Citations: 6. (09/15125-8)

WILLRICH, MARIA ALICE V.; RODRIGUES, ALICE C.; CERDA, ALVARO; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE; LARGURA, ALVARO; et al. Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients. Clinica Chimica Acta, v. 421, p. 157-163, . Web of Science Citations: 14. (08/06667-9)

SILBIGER, VIVIAN N.; HIRATA, MARIO H.; LUCHESSI, ANDRE D.; GENVIGIR, FABIANA D. V.; CERDA, ALVARO; RODRIGUES, ALICE C.; WILLRICH, MARIA A. V.; ARAZI, SIMONE S.; DOREA, EGIDIO L.; BERNIK, MARCIA M. S.; et al. Differentiation of African Components of Ancestry to Stratify Groups in a Case-Control Study of a Brazilian Urban Population. GENETIC TESTING AND MOLECULAR BIOMARKERS, v. 16, n. 6, p. 524-530, . Web of Science Citations: 3.

WILLRICH, MARIA ALICE V.; HIRATA, MARIO H.; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; REBECCHI, IVANISE M. M.; RODRIGUES, ALICE C.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; et al. CYP3A5{*}3A allele is associated with reduced lowering-lipid response to atorvastatin in individuals with hypercholesterolemia. Clinica Chimica Acta, v. 398, n. 1-2, p. 15-20, . Web of Science Citations: 38.

GENVIGIR, FABIANA DALLA VECCFHIA; RODRIGUES, ALICE CRISTINA; CERDA, ALVARO; ARAZI, SIMONE SORKIN; VIEIRA WILLRICH, MARIA ALICE; OLIVEIRA, RAQUEL; HIRATA, MARIO HIROYUKI; DOREA, EGIDIO LIMA; BERNIK, MARCIA MARTINS; CURI, RUI; et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. PHARMACOGENOMICS, v. 11, n. 9, p. 1235-1246, . Web of Science Citations: 16. (06/06196-0, 09/15125-8)

RODRIGUES, ALICE C.; PERIN, PAULA M. S.; PURIM, SHEILA G.; SILBIGER, VIVIAN N.; GENVIGIR, FABIANA D. V.; WILLRICH, MARIA ALICE V.; ARAZI, SIMONE S.; LUCHESSI, ANDRE D.; HIRATA, MARIO H.; BERNIK, MARCIA M. S.; et al. Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A > G Variant Is Determinant of Increased Atorvastatin Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 12, n. 9, p. 5815-5827, . Web of Science Citations: 40. (08/06667-9)

SALAZAR, LUIS A.; HIRATA, MARIO H.; CAVALLI, SELMA A.; NAKANDAKARE, EDNA R.; FORTI, NEUSA; DIAMENT, JAIME; GIANNINI, SERGIO D.; BERTOLAMI, MARCELO C.; HIRATA, ROSARIO D. C.. Molecular Basis of Familial Hypercholesterolemia in Brazil: Identification of Seven Novel LDLR Gene Mutations. Human mutation, v. 19, n. 4, p. 462-463, . Web of Science Citations: 16.

MORETTI REBECCHI, IVANISE MARINA; RODRIGUES, ALICE CRISTINA; ARAZI, SIMONE SORKIN; GENUIGIR, FABIANA DALLA VECCHIA; VIEIRA WILLRICH, MARIA ALICE; HIRATA, MARIO HIROYUKI; SOARES, SARAH APARECIDA; BERTOLAMI, MARCELO CHIARA; FALUDI, ANDRE ARPAD; BERNIK, MARCIA MARTINS SILVEIRA; et al. ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. Biochemical Pharmacology, v. 77, n. 1, p. 66-75, . Web of Science Citations: 23.

RODRIGUES, ALICE C.; NERI, ELIDA ADALGISA; VERISSIMO-FILHO, SIDNEY; REBOUCAS, NANCY AMARAL; HIRATA, ROSARIO D. C.; YU, AI-MING. Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells. European Journal of Pharmaceutical Sciences, v. 93, p. 431-436, . Web of Science Citations: 5. (08/01465-9, 11/05876-6)

WILLRICH, MARIA ALICE V.; HIRATA, MARIO H.; GENVIGIR, FABIANA D. V.; ARAZI, SIMONE S.; REBECCHI, IVANISE M. M.; RODRIGUES, ALICE C.; BERNIK, MARCIA M. S.; DOREA, EGIDIO L.; BERTOLAMI, MARCELO C.; FALUDI, ANDRE A.; et al. CYP3A5{*}3A allele is associated with reduced lowering-lipid response to atorvastatin in individuals with hypercholesterolemia. Clinica Chimica Acta, v. 398, n. 1-2, p. 15-20, . Web of Science Citations: 38.

GENVIGIR‚ F.D.V.; SOARES‚ S.A.; HIRATA‚ M.H.; WILLRICH‚ M.A.V.; ARAZI‚ S.S.; REBECCHI‚ I.M.M.; OLIVEIRA‚ R.; BERNIK‚ M.; DOREA‚ E.L.; BERTOLAMI‚ M.C.; et al. Effects of ABCA1 SNPs‚ including the C-105T novel variant‚ on serum lipids of Brazilian individuals. Clinica Chimica Acta, v. 389, n. 1-2, p. 79-86, .

GENVIGIR, FABIANA DALLA VECCFHIA; RODRIGUES, ALICE CRISTINA; CERDA, ALVARO; ARAZI, SIMONE SORKIN; VIEIRA WILLRICH, MARIA ALICE; OLIVEIRA, RAQUEL; HIRATA, MARIO HIROYUKI; DOREA, EGIDIO LIMA; BERNIK, MARCIA MARTINS; CURI, RUI; et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. PHARMACOGENOMICS, v. 11, n. 9, p. 1235-1246, . Web of Science Citations: 16. (06/06196-0, 09/15125-8)

MORETTI REBECCHI, IVANISE MARINA; RODRIGUES, ALICE CRISTINA; ARAZI, SIMONE SORKIN; GENUIGIR, FABIANA DALLA VECCHIA; VIEIRA WILLRICH, MARIA ALICE; HIRATA, MARIO HIROYUKI; SOARES, SARAH APARECIDA; BERTOLAMI, MARCELO CHIARA; FALUDI, ANDRE ARPAD; BERNIK, MARCIA MARTINS SILVEIRA; et al. ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. Biochemical Pharmacology, v. 77, n. 1, p. 66-75, . Web of Science Citations: 23.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RODRIGUES, Alice Cristina. Efeito da atorvastatina sobre a atividade funcional e expressão de transportadores de membrana do tipo ABC e SLC.  167 f. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas.  Universidade de São Paulo (USP).  São Paulo.  (05/60240-9

HINUY, Hamilton Massayuki. Avaliação de regiões hipervariáveis de genes que predispõem à obesidade.  126 f. Dissertação (Mestrado) -  Faculdade de Ciências Farmacêuticas.  Universidade de São Paulo (USP).  São Paulo.  (00/11700-3

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