Graduated in Pharmacy-Biochemistry by the School of Pharmacy and Dentistry of Ribeirão Preto - USP (1980), Master's degree (1984) and PhD (1991) in Biological Sciences (Biochemistry) by the Ribeirão Preto Medical School of the University of São Paulo, Associate Professor at the Faculty of Pharmaceutical Sciences of Ribeirão Preto - USP (2001). She holds the position of Full Professor at FCFRP-USP since 31/07/2014. She is a Master's and PhD Advisor for the Graduate Program in Toxicology at FCFRP-USP. Acts as Reviewer of scientific journals such as: Toxicon, Biochimie, Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, European Journal of Medicinal Chemistry, British Journal of Pharmacology, Acta Pharmacologica Sinica, Biochimica et Biophysica Acta, Brazilian Journal of Pharmaceutical Sciences, Neurochemistry International, Cellular and Molecular Life Sciences, Protein & Peptide Letters, Journal of Cell Biology and Genetics, The Journal of Venomous Animals and Toxins including Tropical Diseases (Advisory Editor), among others. Provides scientific advice to FAPESP, CNPq, FAPEMIG, UNESP and FAPESB. Participated in the Thematic Committee for Evaluation of proposals submitted to edict MCT / CNPq 70/2008. She was Coordinator of the International Academic Agreement between Universitá di Parma (Italy) and USP through FCFRP. She coordinated the International Academic Agreement between the University of Leuven (Belgium) and USP through FCFRP. She is the Coordinator of the International Academic Agreement between the University of Liege (Belgium) and FCFRP. He is a member of the International Society on Toxinology (IST), the Brazilian Society of Biochemistry (SBBq), the Brazilian Society of Toxinology (SBTx) and the Brazilian Association of Pharmaceutical Sciences (ACBF). She has a registered technological product (Pharmaceutical Compositions containing Hyaluronidase and its uses). She has experience in the field of biochemistry, with emphasis on chemistry of macromolecules (proteins), working mainly on the following topics: biochemical and molecular characterization of toxins isolated from venoms of scorpions, snakes and ants, as well as toad poisons by determining the amino acid sequence, molecular mass, isoelectric point and enzymatic activity (proteases, hyaluronidases, phospholipases, phosphodiesterases and L-amino acid oxidases). Evaluation of their actions on ion channels, hemostatic system, inflammatory process and other biological systems, aiming at the identification of compounds that can be used as models for the development of new drugs or as pharmacological tools. Analysis of transcriptomes and proteomes of animal venoms. The objective is also to obtain the molecules with the highest biotechnological potential by heterologous expression. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Cancer is one of the diseases with the highest incidence, morbidity, and mortality worldwide. InBrazil, the incidence in 2020 was estimated at 670 thousand new cases. Despite scientific andtechnological advances, antitumor treatments have been practiced in the same way for about acentury, that is, combined treatment modalities/techniques: surgery, radiotherapy, chemotherapy, andimmunother…
Technological advances are continually emerging to improve the discovery, rational modification, production and purification of biopharmaceuticals. The identification of different species of microorganisms from Brazilian biodiversity, using innovative strategies, should be carried out with a view to discovering alternative hosts for heterologous expression. The Center for the Study of Poi…
Animal venoms and poisons constitute a rich source of substances with wide-ranging pharmacological activities. The bioprospecting of molecules from animal poisons and venoms combined with the use of biotechnological tools, such as the heterologous expression of toxins and the bioconjugation with polyethylene glycols (PEGs), allows the application of toxins in the development of new therap…
Accidents caused by venomous animals are classified as Neglected Tropical Diseases (NTDs). Currently, the specific treatment available for severe envenoming caused by venomous animals is the use of heterologous antivenons. Although heterologous antivenoms are currently the only effective treatment available for severe envenoming, these sera present several documented undesirable problems:…
Animal venoms are considered as a large natural library, where each molecule is endowed with pharmacological property highly valuable for human use. Because of their great complexity and diversity, the interest for those lethal cocktails has increased. However and despite the efforts, out of 40 million different estimated compounds, only 3,000 have been identified and characterized to dat…
(Only some records are available in English at this moment)
Scorpions are venomous animals belonging to the class Arachnida and are found in various regions around the world. The species Tityus serrulatus is one of the most venomous in the world, being responsible for the majority of scorpion-related incidents in Brazil. The venom of this species contains a wide variety of components, mainly neurotoxins that act on ion channels, with some componen…
Potassium channel-specific scorpion toxins (KTx) are usually small, basic peptides made up of 23-43 amino acids stabilized by 3-4 disulfide bonds. KTx are classified into 6 subfamilies. The Ts16 toxin, isolated from the scorpion Tityus serrulatus, was partially characterized in 2011, demonstrating selectivity for potassium channels of the Kv1 subtype.2. In the same year, another study su…
The venom of the Crotalus durissus collilineatus snake is composed of several bioactive molecules, including collinein-1. This is a serine protease with the ability to interfere with hemostasis control mechanisms and is considered a promising alternative for the treatment of vascular and thrombotic disorders. The biopharmaceutical processes of heterologous expression and PEGylation have p…
(Only some records are available in English at this moment)
The venoms of snakes are considered rich sources of components, including enzymes, peptides, and non-enzymatic proteins. Their various actions induce a wide range of effects, ranging from disturbances in the coagulation system to necrosis and inflammation. Moreover, there are reports of molecules present in snake venoms that increase vascular permeability, induce the proliferation and mig…
The yellow scorpion Tityus serrulatus is one of the species of the genus Tityuspresent in Brazil, being the main cause of accidents by scorpions in the country, and considered the most venomous species of South America. Because of their good adaptation to urban environments and easy dissemination due to its parthenogenetic reproduction, this species has significant epidemiological importa…
Scorpionism has great relevance in Brazil, being responsible for the majority of accidents involving venomous animals in the country and for causing several serious symptoms, which can lead to death. The scorpion species Tityus serrulatus represents a serious threat to human health in Brazil, it is among the animals that produce the most dangerous venoms for mammals representing the highe…
(Only some records are available in English at this moment)
Snake venoms are considered rich sources of compounds with important pharmacological actions. In this way, studying the diverse components allows to clarify the pathogeny of the envenoming and helps identifying molecules with great biotechnological applications. In Brazil, snakes from Crotalus genus, represented by the Crotalus durissus species, inhabit several regions of the country and …
Snakebite accidents affect more than 5 million people worldwide per year, which results in more than 100,000 deaths and around 300,000 amputations or other permanent disabilities, being classified as category A of Neglected Tropical Diseases (NTDs) list in 2017. In Brazil, these accidents are mostly caused by snakes from Bothrops genus, which is distributed throughout the territory. Its v…
Tityus serrulatus is considered the most dangerous scorpion species in Brazil. Its venom contains several compounds with different application potentials. Among these components, there are ±-neurotoxins, which can interact with voltage-gated sodium channels (Nav channels). These toxins are the most reactive and responsible for the toxic effects on scorpion envenoming. Ts5 is a highly toxi…
Snake venoms present a wide range of components able to induce various pathological symptoms in victims of envenoming, which is part of the neglected circumstances by WHO and is a serious public health problem in Brazil. Snakes of Crotalus durissus species represent Crotalus genus in the national territory. Crotalus durissus collilineatus venom presents a great complexity of protein compo…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 16 / 10 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 51 / 29 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 13 / 12 | Completed scholarships abroad |
| 89 / 60 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID