CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Received his Doctor of Veterinary Medicine degree from the University of Sao Paulo (2001) and his PhD degree from the Urology graduate program at the Sao Paulo Federal University (2006). Received his Masters of Business Administration (MBA) degree from Insper - IBMEC/SP in 2011. Currently works at the Sao Paulo Hospital and is a Professor of Urology and graduate advisor at the Urology graduate program at the Sao Paulo Federal University, where he develops his research lines and is Head of the Urological Research Center. Is experienced in Medicine, with an emphasis in Male Infertility, with main research goals in Varicocele, Oxidative Stress, Sperm DNA Fragmentation, and Proteomic Analasis. (Source: Lattes Curriculum)
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Varicocele decreases the seminal and functional quality of sperm and the proteome profile of seminal plasma, for example, we observed an increase in the levels of inflammatory proteins. It is essential to understand the intrinsic mechanisms of transfer and regulation of protein expression present in semen, in addition to establishing inflammatory patterns. Spermatozoa are exposed to extra…
Conventional semen analysis, although routinely utilized during infertility investigation, presents low sensitivity and predictive power for pregnancy. Therefore, new diagnostic methods for male infertility are necessary, among which tests to evaluate sperm functional alterations (DNA fragmentation, mitochondrial activity, acrosome integrity, among others) and semen oxidative stress are o…
Varicocele (VCL) multi-pathologically affects testicular tissue and sperm parameters. In addition, VCL-induced inflammation has a blatant relevance with VCL-induced oxidative stress and VCL-induced negative effects on male fertility. However, it has been revealed that the VCL increases the level of the inflammatory cytokine in both testicular tissue and seminal fluid, there is no evidence…
Seminal parameters such as concentration, motility and morphology are widely used to study male infertility. However, recent years it has been observed that genetic and epigenetic abnormalities have negatively influenced reproductive outcomes and contributed to the diagnosis of idiopathic male infertility. Among them, we highlight the sperm DNA fragmentation, a common phenomenon but when …
Infertility is a conjugal problem that affects 15% of couples in reproductive age, in which the male factor is present in 50% of the cases. The etiology of the problem steam from several factors, for example illness or lifestyle. Despite semen analysis been utilized as a method for evaluation of male fertile potential, it has a low correlation with fertility, being unable of accurately di…
Conventional semen analysis - the initial method to evaluate male fertile potential - presents low correlation with fertility, and is insufficient as a diagnostic method of male infertility. It is important to have a better understanding of the molecular mechanisms that lead to changes in the sperm and, consequently to fertility disorders. Among the molecules that are related to sperm fun…
Oxidative stress is a factor that contributes significantly to male infertility. It is defined by the accumulation of reactive oxygen species (ROS) resulting from its increase or decrease in the amount of antioxidants. The membrane of the sperm by having large amount of polyunsaturated fatty acids becomes susceptible to ROS action leading to occurrence of lipid peroxidation, resulting in …
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As varicocele alters the proteomic profile in seminal plasma, it is fundamental to understand what are the intrinsic mechanisms of protein regulation presents in testicular and epididymal environment. One of the major post- transcriptional mechanisms to control the protein expression is given by action of non-coding RNAs, denominated microRNAs (miRNAs). Thus, our hypotheses are: (i) there…
Although semen analysis is essential during infertility investigation, and may provide information about male fertile potential, it is insufficient as a diagnostic method of male infertility. Thus, additional methods for its evaluation are required. In this context, evaluating the sperm proteome of fertile and infertile men, as well as the phosphorylated proteins (regulators of post-testi…
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 10 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 17 / 16 | All research grants and scholarships |
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