CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciencias Biologicas from Universidade Estadual de Campinas (2002), master's at Clinical Medicine from Universidade Estadual de Campinas (2004) and doctorate at Clínica Médica/Neuro-imunologia from Universidade Estadual de Campinas (2009). He is currently assistant professor at Universidade Estadual de Campinas. Has experience in Immunology, focusing on Immunology, acting on the following subjects: eae, regulacao imunologica, neuroimunologia, vitamina d and esclerose múltipla. (Source: Lattes Curriculum)
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Our group has been focusing in the essential conditions to the pathogenicity of encephalitogenic T CD4+ cells during the early stage of EAE. Our preliminary results indicate that STAT5/CIS pathway could play an important role after these cells reach the central nervous system. We believe that this pathway could be essential to the conversion of Th17 into IFN³-producing cells, which we…
Flow cytometry is a technology that provides the analysis of physical and chemical characteristics of a particular suspended particle. Flow cytometry allows the detection of multiple simultaneous characteristics (size, complexity and fluorescence intensity) of an individualized particle or cell. After the advent of monoclonal antibodies, the main application of flow cytometry was the iden…
Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenerative autoimmune disease of the central nervous system (CNS), in which encephalitogenic lymphocytes attack and destroy myelin, interfering with the transmission of electrical signal and therefore, in the communication between neurons. In the Experimental autoimmune encephalomyelitis (EAE), experimental model of MS, it has …
Experimental autoimmune encephalomyelitis (EAE) is a widely accepted animal model of MS that has been used to study the pathophysiology of the disease since first being described in 1933. It shares many pathological features with MS, such as chronic neuroinflammation, demyelination, and neuronal damage, and is generated by autoimmune attack on the CNS3,4. EAE can be induced in susceptible…
The experimental auto-immune encephalomyelitis (EAE) and experimental auto-immune neuritis are experimental models of autoimmune T cells mediated diseases, since these diseases can be adoptively transferred to naive animals by T CD4 lymphocytes transfer. The effector function of these lymphocytes, however, can be decreased by regulatory T lymphocytes. On the other hand, the auto-reactive …
Multiple Sclerosis (MS) is an inflammatory and autoimune disease of the Central Nervous System (CNS). The cytotoxic activity of T lymphocytes has been reported as an effector mechanism for MS development. Moreover, it has been shown that the presence of cytotoxic CD4+ T cells (CD4_CTLs) drives MS progression and that these cells contribute to MS lesions by targeting oligodendrocytes. In t…
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was discovered in December 2019 in Wuhan, China, and quickly spread across the globe due to its ability to transmit before symptoms manifest, causing the pandemic as Coronavirus 2019 disease (COVID-19). Until October 7, 2021, the virus was able to infect around 236 million individuals and causes the death of 4.8 million. Bra…
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system. In MS, a primarily cellular immune response is described, with the participation of Th1 and Th17 lymphocytes, although the presence of anti-MOG and anti-MBP antibodies in the context of the disease is known, for example. Recent studies have shown the presence of ectopic B-lymphocyte niches in the …
Experimental autoimmune encephalomyelitis (EAE) serves as experimental model of multiple sclerosis (MS) since both diseases share clinical and histopathological similarities. EAE is a CD4+ T cell-mediated autoimmune disease. Although it is clear that encephalitogenic CD4+ T cells perform a proinflammatory activity, how these T helper cells are able to exert effector role during the clinic…
Type 1 diabete (DM1A) is one of the most common diseases of the childhood and of the adolescence. There is a heterogeneity in its clinical expression, depending on the extension of the destruction of the ß pancreatic cells by the autoreactive T lymphocytes. Due to the difficult to assess human Langerhans islets in vivo, most of knowledge regarding this human disorder were acquired through…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 26 / 23 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 141 |
| Cit./Article | 12.8 |
| Data from Web of Science | |
BOLDRINI, VINICIUS O.; BRANDAO, CARLOS OTAVIO; PIMENTEL, V, MARIA LUCIA; VIDAL, ALINE; MANSUR, LETICIA F.; QUINTILIANO, RAPHAEL P. S.; SANTOS, LEONILDA M. B.; FARIAS, ALESSANDRO S.. Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder. Journal of Neuroimmunology, v. 340, MAR 15 2020. Web of Science Citations: 0. (17/21363-5, 15/22052-8, 12/01408-0, 19/06372-3)
VON GLEHN, FELIPE; JARIUS, SVEN; CAVALCANTI LIRA, RODRIGO PESSOA; ALVES FERREIRA, MARIA CAROLINA; RIBEIRO VON GLEHN, FADUA H.; COSTA E CASTRO, STELLA MARIS; BELTRAMINI, GUILHERME COCO; BERGO, FELIPE P. G.; FARIAS, ALESSANDRO S.; BRANDAO, CARLOS OTAVIO; et al. Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders. MULTIPLE SCLEROSIS, v. 20, n. 9, p. 1189-1197, AUG 2014. Web of Science Citations: 27. (11/18728-5, 12/04565-0)
PASCOAL, LIVIA BITENCOURT; RODRIGUES, PATRICIA BRITO; GENARO, LIVIA MOREIRA; DOS SANTOS PEREIRA GOMES, ARILSON BERNARDO; TOLEDO-TEIXEIRA, DANIEL AUGUSTO; PARISE, PIERINA LORENCINI; BISPO-DOS-SANTOS, KARINA; SIMEONI, CAMILA LOPES; GUIMARAES, PAULA VERI; BUSCARATTI, LUCAS ILDEFONSO; et al. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. GUT MICROBES, v. 13, n. 1, p. 1-9, JAN 1 2021. Web of Science Citations: 0. (20/04558-0, 13/07607-8, 19/06372-3, 20/04579-7, 20/04746-0, 20/02448-2, 20/02159-0, 20/04583-4, 20/02312-3, 17/26908-0, 20/04919-2, 19/14342-7)
FACHI, J. L.; PRAL, L. P.; DOS SANTOS, J. A. C.; CODO, A. C.; DE OLIVEIRA, S.; FELIPE, J. S.; ZAMBOM, F. F. F.; CAMARA, N. O. S.; VIEIRA, P. M. M. M.; COLONNA, M.; et al. Hypoxia enhances ILC3 responses through HIF-1 alpha-dependent mechanism. MUCOSAL IMMUNOLOGY, v. 14, n. 4, JAN 2021. Web of Science Citations: 1. (19/11662-0, 18/02208-1, 18/22505-0, 19/06372-3, 17/06577-9, 18/15313-8, 15/15626-8, 17/16280-3)
BRANDAO, W. N.; DE OLIVEIRA, M. G.; ANDREONI, R. T.; NAKAYA, H.; FARIAS, A. S.; PERON, J. P. S.. Neuroinflammation at single cell level: What is new?. Journal of Leukocyte Biology, AUG 2020. Web of Science Citations: 0. (13/08216-2, 18/21934-5, 17/50137-3, 17/26170-0, 12/19278-6, 17/22504-1, 17/21363-5, 18/14933-2, 19/06372-3)
FARIAS, ALESSANDRO S.; MARTINS-DE-SOUZA, DANIEL; GUIMARAES, LEANDRO; PRADELLA, FERNANDO; MORAES, ADRIEL S.; FACCHINI, GUSTAVO; NOVELLO, JOSE CAMILLO; SANTOS, LEONILDA M. B.. Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis. PROTEOMICS, v. 12, n. 17, SI, p. 2656-2662, AUG 2012. Web of Science Citations: 10. (11/18728-5, 09/15620-9, 09/18227-6)
FARIAS, ALESSANDRO S.; SPAGNOL, GABRIELA S.; BORDEAUX-REGO, PEDRO; OLIVEIRA, CAMILA O. F.; FONTANA, ANA GABRIELA M.; DE PAULA, ROSEMEIRE F. O.; SANTOS, MARIANA P. A.; PRADELLA, FERNANDO; MORAES, ADRIEL S.; OLIVEIRA, ELAINE C.; et al. Vitamin D-3 Induces IDO+ Tolerogenic DCs and Enhances Treg, Reducing the Severity of EAE. CNS Neuroscience & Therapeutics, v. 19, n. 4, p. 269-277, APR 2013. Web of Science Citations: 72. (11/18728-5, 11/15175-5, 12/01408-0, 11/15639-1)
FARIAS, ALESSANDRO S.; TALAISYS, RAFAEL L.; BLANCO, YARA C.; LOPES, STEFANIE C. P.; LONGHINI, ANA LEDA F.; PRADELLA, FERNANDO; SANTOS, LEONILDA M. B.; COSTA, FABIO T. M.. Regulatory T Cell Induction during Plasmodium chabaudi Infection Modifies the Clinical Course of Experimental Autoimmune Encephalomyelitis. PLoS One, v. 6, n. 3, p. e17849, 2011. Web of Science Citations: 20. (09/15620-9)
MORAES, ADRIEL S.; PAULA, ROSEMEIRE F. O.; PRADELLA, FERNANDO; SANTOS, MARIANA P. A.; OLIVEIRA, ELAINE C.; VON GLEHN, FELIPE; CAMILO, DANIELA S.; CERAGIOLI, HELDER; PETERLEVITZ, ALFREDO; BARANAUSKAS, VITOR; et al. The Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells Induced by Multiwalled Carbon Nanotubes Reduces the Severity of Experimental Autoimmune Encephalomyelitis. CNS Neuroscience & Therapeutics, v. 19, n. 9, p. 682-687, SEP 2013. Web of Science Citations: 12. (11/18728-5, 12/09879-2, 12/01408-0, 12/04565-0, 11/15175-5, 11/15639-1)
BOLDRINI, VINICIUS DE OLIVEIRA; FARIAS, ALESSANDRO DOS SANTOS; DEGASPERI, GIOVANNA ROSA. Deciphering targets of Th17 cells fate: From metabolism to nuclear receptors. Scandinavian Journal of Immunology, v. 90, n. 4, JULY 2019. Web of Science Citations: 0. (17/21363-5)
DE FREITAS, LEONARDO PIMENTEL. M-CSF- and L929-derived macrophages present distinct metabolic profiles with similar inflammatory outcomes. Immunobiology, v. 225, n. 3, MAY 2020. Web of Science Citations: 0. (16/18031-8, 15/15626-8, 16/23328-0, 19/06372-3)
BOLDRINI, VINICIUS O.; QUINTILIANO, RAPHAEL P. S.; SILVA, LUCAS S.; DAMASCENO, ALFREDO; SANTOS, LEONILDA M. B.; FARIAS, ALESSANDRO S.. Cytotoxic profile of CD3+CD20+T cells in progressive multiple sclerosis. MULTIPLE SCLEROSIS AND RELATED DISORDERS, v. 52, JUL 2021. Web of Science Citations: 0. (17/21363-5, 19/06372-3, 14/26431-0)
PERON, J. P. S.; NAKAYA, I, H.; SCHLINDWEIN, M. A. M.; GONCALVES, M. V. M.. COVID-19 Pandemic and Dysbiosis: Can the Ivermectin Hysteria Lead to an Increase of Autoimmune Neuroinflammatory Diseases?. CRITICAL REVIEWS IN IMMUNOLOGY, v. 40, n. 6, SI, p. 537-542, 2020. Web of Science Citations: 0. (17/22504-1, 18/14933-2, 12/19278-6, 13/08216-2, 18/21934-5, 19/06372-3, 17/21363-5)
(References retrieved automatically from State of São Paulo Research Institutions)
PRADELLA, Fernando. Efeito da administração do G-CSF nos mecanismos efetores e imunorreguladores na neurite experimental autoimune induzida em ratos Lewis = : Effect of the administration of the G-CSF onto the effector and immuneregulatory mechanisms of the experimental autoimmune neuritis induced in Lewis rats. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (11/15175-5)
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