graduation at Ciencias Biologicas from Universidade Estadual de Campinas (2002), master's at Clinical Medicine from Universidade Estadual de Campinas (2004) and doctorate at Clínica Médica/Neuro-imunologia from Universidade Estadual de Campinas (2009). He is currently assistant professor at Universidade Estadual de Campinas. Has experience in Immunology, focusing on Immunology, acting on the following subjects: eae, regulacao imunologica, neuroimunologia, vitamina d and esclerose múltipla. (Source: Lattes Curriculum)
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What shapes the rate of aging of a given species or individual? Despite the recent advances in the field of biogerontology, this fundamental question remains without a comprehensive answer. Nutrition, reproduction and exposure to environmental threats (such as pathogens) are among the most important driving forces shaping life history. At the cornerstone of how these elements impact lifes…
Flow cytometry is a technology that provides the analysis of physical and chemical characteristics of a particular suspended particle. Flow cytometry allows the detection of multiple simultaneous characteristics (size, complexity and fluorescence intensity) of an individualized particle or cell. After the advent of monoclonal antibodies, the main application of flow cytometry was the iden…
Our group has been focusing in the essential conditions to the pathogenicity of encephalitogenic T CD4+ cells during the early stage of EAE. Our preliminary results indicate that STAT5/CIS pathway could play an important role after these cells reach the central nervous system. We believe that this pathway could be essential to the conversion of Th17 into IFN³-producing cells, which we…
Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenerative autoimmune disease of the central nervous system (CNS), in which encephalitogenic lymphocytes attack and destroy myelin, interfering with the transmission of electrical signal and therefore, in the communication between neurons. In the Experimental autoimmune encephalomyelitis (EAE), experimental model of MS, it has …
Experimental autoimmune encephalomyelitis (EAE) is a widely accepted animal model of MS that has been used to study the pathophysiology of the disease since first being described in 1933. It shares many pathological features with MS, such as chronic neuroinflammation, demyelination, and neuronal damage, and is generated by autoimmune attack on the CNS3,4. EAE can be induced in susceptible…
(Only some records are available in English at this moment)
Multiple Sclerosis (MS) is an inflammatory and autoimune disease of the Central Nervous System (CNS). The cytotoxic activity of T lymphocytes has been reported as an effector mechanism for MS development. Moreover, it has been shown that the presence of cytotoxic CD4+ T cells (CD4_CTLs) drives MS progression and that these cells contribute to MS lesions by targeting oligodendrocytes. In t…
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was discovered in December 2019 in Wuhan, China, and quickly spread across the globe due to its ability to transmit before symptoms manifest, causing the pandemic as Coronavirus 2019 disease (COVID-19). Until October 7, 2021, the virus was able to infect around 236 million individuals and causes the death of 4.8 million. Bra…
COVID-19 is an emerging disease, caused by the SARS-CoV-2 virus, which has become pandemic in recent months. Several studies have shown that the number of T lymphocytes in patients infected with SARS-CoV-2 is drastically reduced. The impairment of lymphocyte activity can be fundamental for the quality of the response against SARS-CoV-2, being characterized as a possible escape mechanism o…
Experimental autoimmune encephalomyelitis (EAE) serves as experimental model of multiple sclerosis (MS) since both diseases share clinical and histopathological similarities. EAE is a CD4+ T cell-mediated autoimmune disease. Although it is clear that encephalitogenic CD4+ T cells perform a proinflammatory activity, how these T helper cells are able to exert effector role during the clinic…
Type 1 diabete (DM1A) is one of the most common diseases of the childhood and of the adolescence. There is a heterogeneity in its clinical expression, depending on the extension of the destruction of the ß pancreatic cells by the autoreactive T lymphocytes. Due to the difficult to assess human Langerhans islets in vivo, most of knowledge regarding this human disorder were acquired through…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 27 / 24 | All research grants and scholarships |
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