CV Lattes
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ORCID
Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate in Medicine and PH.D. and Full professor in Infectious Diseases Pathology. Associate professor of Dept.Pathology FMUSP and previous chief of Protozoology Lab. at Tropical Medicine Institute, both at University of São Paulo. His main projects are devoted to the pathology of infectious diseases, in all of their aspects, specially from protozoan diseases. Promoted and was the first coordinator of Masters and Ph.D.s program in Tropical Medicine, whihc was evaluated as 5 by CAPES. Their main diagnostic projects are devoted to protozoan diseases, as toxoplamosis, malaria and leishmaniasis. Aside to this aplicated approaches, he also defveloped projects in cell imunity of malaria, studying progenitor cells in spleen on gene expression of axis CXCL12-CXCR4-CXCR7, as well as population studies on haplotypes of those genes. For molecular epidemiology, we also study phlebotomine infections by leishmania and sources of outbreaks of human or animal toxoplasmosis. He is also a collaborator in the Instituto Nacional de Ciência e Tecnologia para Febres Hemorrágicas Virais, do Instituto Evandro Chagas e coordenado pelo Prof. P. Vasconcelos, dealing with the in situ immune response in affected patients. (Source: Lattes Curriculum)
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Visceral leishmaniasis (VL) is an epidemic in Brazil, and its diagnosis and immunology have been studied using classical or protein antigens in general. Haptens are macromolecules of molecular weight between 1 and 5 KDa which are composed of peptides, small polysaccharides and complex lipids, and which have the ability to react with antibodies and immune cells incompletely, perhaps interf…
We studied the diagnosis and pathogenic process in endemic human and experimental infections caused by protozoa and other infectious agents, especially toxoplasmosis, mostly devoted to the detection of infections by specific antibodies and the evaluation of an oral vaccine with irradiated parasites for felids. In the detection of specific antibodies, the main tool is the ELISA and their v…
Several research groups at the USP School of Medicine supported by LIM - Laboratories for Medical Research and also affiliated with the São Paulo Institute of Tropical Medicine (IMTSP) - have long been devoted to the study and control of transmissible diseases. We are mainly involved in the study of tropical and neglected diseases, in all their aspects, as experimental models, vaccine and…
(Only some records are available in English at this moment)
There is a large amount of immunoglobulins in the serum of patients and animals with visceral leishmaniasis (VL), which may be involved in or resulting from its pathogenesis. Antigenic characterization of antibodies produced in VL is poorly defined and can be targeted to antigens of different classes, such as proteins, glycoproteins and carbohydrates. The involvement of haptens in the hum…
Antibody detection reactions using antigen adsorbed on the solid phase depend on adequate dilution of the biological sample, such as sera. Some samplings do not allow this precise dilution, such as filter paper collections or cell purification supernatants, resulting in less sensitivity and specificity. This is a problem in experimental models, where the small volume of blood of experimen…
In visceral leishmaniasis occurs a high production of polyclonal antibodies and B cells, unrelated to the parasite burden or disease control by the host. Glycoconjugates are widely distributed in the membrane of leishmanias, such as lipofosfoglican (LPG), glycoinositolphopholipids (GIPLs), phosphoglycans (GPI), and glycoprotein GP63. Its presence is related to resistance and survival of t…
(Only some records are available in English at this moment)
| 12 / 6 | Completed research grants |
| 15 / 5 | Completed scholarships in Brazil |
| 27 / 11 | All research grants and scholarships |
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