Heitor Franco de Andrade Junior
CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Medicina Tropical de São Paulo (IMT) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Medicine and PH.D. and Full professor in Infectious Diseases Pathology. Associate professor of Dept.Pathology FMUSP and chief of Protozoology Lab. at Tropical Medicine Institute, both at University of São Paulo. His main projects are devoted to the pathology of infectious diseases, in all of their aspects, specially from protozoan diseases. Promoted and was the first coordinator of Masters and Ph.D.s program in Tropical Medicine, whihc was evaluated as 5 by CAPES. Their main diagnostic projects are devoted to protozoan diseases, as toxoplamosis, malaria and leishmaniasis. Aside to this aplicated approaches, he also defveloped projects in cell imunity of malaria, studying progenitor cells in spleen on gene expression of axis CXCL12-CXCR4-CXCR7, as well as population studies on haplotypes of those genes. For molecular epidemiology, we also study phlebotomine infections by leishmania and sources of outbreaks of human or animal toxoplasmosis. He is also a collaborator in the Instituto Nacional de Ciência e Tecnologia para Febres Hemorrágicas Virais, do Instituto Evandro Chagas e coordenado pelo Prof. P. Vasconcelos, dealing with the in situ immune response in affected patients. (Source: Lattes Curriculum)
- Haptens in visceral leishmaniasis. development of solid phase assays for diagnosis and its immunology in experimental models, AP.R
Abstract
Visceral leishmaniasis (VL) is an epidemic in Brazil, and its diagnosis and immunology have been studied using classical or protein antigens in general. Haptens are macromolecules of molecular weight between 1 and 5 KDa which are composed of peptides, small polysaccharides and complex lipids, and which have the ability to react with antibodies and immune cells incompletely, perhaps inte...
- Flow cytometry and fluorimetry in diseases caused by protozoa, AP.R
Abstract
We studied the diagnosis and pathogenic process in endemic human and experimental infections caused by protozoa and other infectious agents, especially toxoplasmosis, mostly devoted to the detection of infections by specific antibodies and the evaluation of an oral vaccine with irradiated parasites for felids. In the detection of specific antibodies, the main tool is the ELISA and their...
- Fluorometry and cytofluorometry in the investigation of transmitted diseases, AP.EMU
Abstract
Several research groups at the USP School of Medicine supported by LIM - Laboratories for Medical Research and also affiliated with the São Paulo Institute of Tropical Medicine (IMTSP) - have long been devoted to the study and control of transmissible diseases. We are mainly involved in the study of tropical and neglected diseases, in all their aspects, as experimental models, vaccine a...
- Determination of haplotypes of CXCL12-CXCR4/CXCR7 axis genes in malaria patients from Brazil and Africa, AP.R
Abstract
Malaria, one of the main endemic diseased in the World, courses with varied severity, associated either to parasite or host factors. Caused by the same parasite, in special P. falciparum, the disease appears to have no specific parasitic determinants for severity of human disease. Malaria control is dependent of harmonic amplification of spleen structure and adequate immune response, me...
(Only some records are available in English at this moment)
- Detection of specific antibodies against T. gondii in samples with varying concentrations of IgG by capture assay in protein a and reaction with high sensitivity antigen, BP.IC
Abstract
Antibody detection reactions using antigen adsorbed on the solid phase depend on adequate dilution of the biological sample, such as sera. Some samplings do not allow this precise dilution, such as filter paper collections or cell purification supernatants, resulting in less sensitivity and specificity. This is a problem in experimental models, where the small volume of blood of experim...
- Evaluation of the maturation profile of IgG antibodies anti-hapten polysaccharide and peptide in visceral leishmaniasis, BP.IC
Abstract
In visceral leishmaniasis occurs a high production of polyclonal antibodies and B cells, unrelated to the parasite burden or disease control by the host. Glycoconjugates are widely distributed in the membrane of leishmanias, such as lipofosfoglican (LPG), glycoinositolphopholipids (GIPLs), phosphoglycans (GPI), and glycoprotein GP63. Its presence is related to resistance and survival of...
- The importance of proteases provision essential amino acids sources in Leishmania (Leishmania) infantum promastigotes, BP.MS
Abstract
Visceral leishmaniasis (VL) is a disease widely distributed worldwide that infects more than 300,000 people a year, which can lead to death 95% of symptomatic cases without treatment and that is epidemic in Brazil. In vertebrates, it is a parasite of cells of the mononuclear phagocytic system and the medicines used have important side effects. The species responsible for LV in Brazil is...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 11 / 5 | Completed research grants |
| 14 / 4 | Completed scholarships in Brazil |
| 26 / 10 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 6 |
| Cit./Article | 2.0 |
| Data from Web of Science | |
RM HIRAMOTO; M MAYRBAURL-BORGES; AJ GALISTEO JR; LR MEIRELES; MS MACRE; HF ANDRADE JR. Infectivity of cysts of the ME-49 Toxoplasma gondii strain in bovine milk and homemade cheese. Revista de Saúde Pública, v. 35, n. 2, p. 113-118, Abr. 2001.
GARNICA‚ M.R.; SOUTO‚ J.T.; SILVA‚ J.S.; DE ANDRADE‚ H.F.; OTHERS. Stromal cell derived factor 1 synthesis by spleen cells in rodent malaria‚ and the effects of in vivo supplementation of SDF-1 [alpha] and CXCR4 receptor blocker. Immunology Letters, v. 83, n. 1, p. 47-53, 2002.
GARNICA‚ M.R.; SILVA‚ J.S.; DE ANDRADE JUNIOR‚ H.F.. Stromal cell-derived factor-1 production by spleen cells is affected by nitric oxide in protective immunity against blood-stage< i> Plasmodium chabaudi CR in C57BL/6j mice. Immunology Letters, v. 89, n. 2, p. 133-142, 2003.
LUCIANA REGINA MEIRELES; ANDRÉS JIMENEZ GALISTEO JR.; HEITOR FRANCO DE ANDRADE JR.. Serological survey of antibodies to Toxoplasma gondii in food animals from São Paulo state, Brazil. Brazilian Journal of Veterinary Research and Animal Science, v. 40, n. 4, p. 267-271, 2003.
DE CARVALHO, CAMILA APARECIDA; FERRAO, THIAGO FIDELIS; NOVAIS DE FREITAS, FLAVIA REGINA; DE ANDRADE JUNIOR, HEITOR FRANCO. High levels of serum glycans monovalent IgG immune complexes detected by dissociative ELISA in experimental visceral leishmaniasis. IMMUNOLOGY, v. 158, n. 4, p. 314-321, DEC 2019. Web of Science Citations: 0.
RODRIGUES, J. P.; ANDRADE, JR., H. F.. Efficient duplex solid-phase fluorescent assay (dFISA) for the simultaneous detection of specific anti-T. gondii IgG and IgM due to refined conjugates. JOURNAL OF IMMUNOLOGICAL METHODS, v. 420, p. 11-17, MAY 2015. Web of Science Citations: 0.
HIRAMOTO‚ R.M.; GALISTEO‚ A.J.; DO NASCIMENTO‚ N.; DE ANDRADE‚ H.F.; OTHERS. 200 Gy sterilised Toxoplasma gondii tachyzoites maintain metabolic functions and mammalian cell invasion‚ eliciting cellular immunity and cytokine response similar to natural infection in mice. Vaccine, v. 20, n. 16, p. 2072-2081, 2002.
LUCIANA NEVES PASSOS; ORLANDO FLORENTINO DE ARAÚJO FILHO; HEITOR FRANCO DE ANDRADE JUNIOR. Toxoplasma encephalitis in AIDS patients in São Paulo during 1988 and 1991. A comparative retrospective analysis. Revista do Instituto de Medicina Tropical de São Paulo, v. 42, n. 3, p. 141-145, Jun. 2000.
TEMPONE‚ AG; TREIGER BORBOREMA‚ SE; DE ANDRADE‚ HF; DE AMORIM GUALDA‚ NC; YOGI‚ A.; SALERNO CARVALHO‚ C.; BACHIEGA‚ D.; LUPO‚ FN; BONOTTO‚ SV; FISCHER‚ DCH. Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families. Phytomedicine, v. 12, n. 5, p. 382-390, 2005.
MEIRELES‚ LR; GALISTEO JR‚ AJ; POMPEU‚ E.; ANDRADE JR‚ HF. Toxoplasma gondii spreading in an urban area evaluated by seroprevalence in free-living cats and dogs. TROPICAL MEDICINE & INTERNATIONAL HEALTH, v. 9, n. 8, p. 876-881, 2004.
LUCIANA REGINA MEIRELES; ANDRÉS JIMENEZ GALISTEO JR.; HEITOR FRANCO DE ANDRADE JR.. Serological survey of antibodies to Toxoplasma gondii in food animals from São Paulo state, Brazil. Brazilian Journal of Veterinary Research and Animal Science, v. 40, n. 4, p. 267-271, 2003.
DE CARVALHO, CAMILA APARECIDA; FERRAO, THIAGO FIDELIS; NOVAIS DE FREITAS, FLAVIA REGINA; DE ANDRADE JUNIOR, HEITOR FRANCO. High levels of serum glycans monovalent IgG immune complexes detected by dissociative ELISA in experimental visceral leishmaniasis. IMMUNOLOGY, v. 158, n. 4, p. 314-321, DEC 2019. Web of Science Citations: 0.