CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Luiz Rodolpho Raja Gabaglia Travassos in research grants and scholarships supported by FAPESP.
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Studies on the structure and mechanisms of action of bioactive peptides and peptidases in experimental models of infectious diseases and cancer. All subprojects depend on an active sector of synthesis and analysis of peptides as installed at the Biophysics Department of UNIFESP. Peptides and peptidases are so broadly involved in the functioning of cells and multicellular organisms that vi…
Peptides and peptidases are involved in such a way in the functioning of cells and of multi-cell organisms that practically the entire biological system or experimental model of some form uses substrates, mediators, inhibitors, antibiotics or antigens of peptidic nature as well as regulatory enzymes, which degrade, generate or chaperone peptides. The different biological activities of pep…
Numerous attempts have been made in the last decades to apply concepts and experimental data on the immune response induced by malignant tumors to elaborate immunotherapeutic protocols, using a variety of immunizing agents. Monoclonal antibodies, irradiated tumor cells, transfected or not with cytokine genes, activated lymphocytes and NK cells, tumor-infiltrating lymphocytes, viral vector…
(Only some records are available in English at this moment)
Cutaneous melanoma is a letal type of skin cancer in which the therapeutic resistance is associated to a modulated tumor microenvironment. Although of melanoma cells are uniquely immunogenic, they adapt to suppress innate and adaptive immunity by expressing several factors that play a central role in immunoediting. One of these cytokines is the macrophage migration inhibitory factor (MIF)…
Previous results have demonstrated that peptides derived from CDRs immunoglobulins exhibit activity in vitro and in vivo against human cancer cell lines and against murine melanoma B16F10-Nex2 in syngeneic model C57BI6 H-2b mice. (Arruda et al, 2012; Dobroff et al., 2010). Anti-tumor effects observed after intraperitoneal injection of peptides could be reproduced using syngeneic dendritic…
The effective anti-cancer immune response involves the participation of several mechanisms with the participation of antibodies, T Lymphocytes, cytokines, macrophages, with dendritic cells (DCs) as central elements, directing the basic nature of the antitumor immunity. It is widely recognized the potential of cancer rejection through the recognition of specific tumor antigens mainly by T …
(Only some records are available in English at this moment)
Cutaneous melanoma is an immunogenic malignancy. Spontaneous regression of melanoma by an effective antitumor immune response can occur occasionally. More frequently, however, key driver mutations are important to support melanoma progression and resistance to immune protection. The genetic instability of melanoma may trigger the expression of several immunosuppressive factors that help m…
The effective anti-cancer immune response involves several effector mechanisms involving antibodies, T lymphocytes, cytokines, macrophages and dendritic cells as central elements, associating tumor antigen recognition and anti-tumour immunity. Our laboratory, in collaboration with researchers from the University of Parma, Italy, showed that short peptide sequences from complementarity-det…
| 10 / 5 | Completed research grants |
| 31 / 10 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 43 / 17 | All research grants and scholarships |
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