CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas (Licenciatura) from Universidade de São Paulo (2004), bachelor's at Ciências Biológicas (Bacharelado) from Universidade de São Paulo (2004) and doctorate at Genetics from Universidade de São Paulo (2009). Has experience in Biochemistry, focusing on Biochemistry (Source: Lattes Curriculum)
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SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), like SARS-CoV from 2003 and MERS-CoV from 2012, is part of the Betacoronavirus genus of the Nidovirales order and is currently the virus that causes the pandemic called COVID- 19 (Coronavirus disease 2019). SARS-CoV-2 causes an acute respiratory disease or SARS, characterized by fever, cough, fatigue and severe cases of pneumon…
Despite diagnostic and therapeutic advances in the last decades, cancer is still one of the deadliest diseases around the world. The lack of a cure for cancer reflects the complexity of its molecular bases, where the deregulation of cellular metabolic pathways is considered one of the emerging hallmarks of the disease. Therefore, there is currently a great demand for a better understandin…
In the last years, the number of obese people has increased worldwidely, which also leads to an increase of a number of diseases associated with obesity such as diabetes type II, coronary artery disease, cerebrovascular accident, osteo-degenerative diseases and cancer. Therefore, there is currently a great demand for a better understanding of the biochemical and metabolic processes relate…
Breast cancer is the most common neoplasm among women globally, representing a significant public health challenge due to its high mortality rate associated with tumor progression and metastasis formation. In this context, S6 kinases (S6Ks) have attracted attention as potential mediators in these processes, given their importance in regulating protein synthesis and cell growth control as …
A new outbreak of lung disease caused by a new Coronavirus appeared in Wuhan (capital of the province of Hubei in China) in December 2019 and has spread to different parts of the world, which has prompted the World Health Organization to confirm the outbreak as a pandemic on March 11, 2020. The new coronavirus SARS-CoV-2 genome is composed of a single-stranded positive-sense RNA (+ ssRNA)…
Cancer is a disease with a high global prevalence, being a primary topic for investment instudies. Recently there have been advances in the understanding of the mechanisms, but there is still a lack of efficient treatments and ways to improve the survival of patients with current treatments. Among the types of cancer, lung cancer is one of the most prevalent in the world and the one thatc…
According to the National Cancer Institute (INCA) breast cancer is the most common cancer among women in the world; in 2020, 2.3 million new cases were estimated. Regarding treatment, it is known that the use of PARP1 inhibitors (Poly (ADP-ribose) Polymerase 1) for individuals with a BRCA1/2 mutation is a relevant therapeutic strategy based on synthetic lethality. S6K1/2 proteins mediate …
LKB1 is an important upstream inhibitor of the mTOR/S6Ks pathway. Loss of LKB1 is often associated with cancer, including in A549 lung cancer cell line, boosting the transformation of pre-malignant neoplasic cells. Metformin, a natural compound derived from Galega officinalis, is mainly used as a treatment for diabetes mellitus type 2 (DM2), but recently, it has been associated to lower i…
(Only some records are available in English at this moment)
Colorectal cancer (CRC) is the third most common cancer diagnosed globally, and the number of survivors has been increasing significantly due to earlier diagnoses and advancements in treatment. Unfortunately, 50% of CRC patients that survive will develop debilitating musculoskeletal (MSK) deterioration, along with accelerated features of aging, such as increased frailty, morbidity, and mo…
A new outbreak of lung disease caused by a new coronavirus emerged in Wuhan (capital of Hubei Province in China) in December 2019 and, since spread to different parts of the world which, has led the World Health Organization to confirm the outbreak as a pandemic on March 11, 2020, naming the new virus SARS-CoV-2. NSP9, the non-structural protein (NSP) 9 of SARS-CoV-2, directly participate…
Genomic instability is a hallmark of cancer characterized by an increased rate of alterations in the genome, which favors tumorigenesis and tumor progression. Luckily, cells have mechanisms such as DNA repair, which respond to the presence of DNA damage and help maintain genomic integrity and stability. Recently, the S6K1 protein, a target of mTORC1, has been linked to DNA repair. Particu…
mTOR pathway has been suggested as a central mechanism that converges different signaling pathways to coordinate cell growth and is commonly reported overactivated in cancer. Once activated by growth factors, amino acids, or energy (ATP/AMP ratio), mTOR induces the cap-dependent translation and ribosome biogenesis, increasing protein synthesis and other anabolic processes. mTOR is respons…
(Only some records are available in English at this moment)
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 19 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 36 / 30 | All research grants and scholarships |
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