bachelor's at Medicina from Universidad de Buenos Aires (1974) and doctorate at Microbiologia E Parasitologia from Universidad de Buenos Aires (1981). He is currently full professor at Universidade de São Paulo. Has experience in Parasitology, focusing on Human Parasite Protozoology, acting on the following subjects: malaria, plasmodium falciparum, drogas anti-malaricas, isoprenoides and trypanosoma cruzi. (Source: Lattes Curriculum)
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A fact which favors the increase in morbidity and mortality from Malaria in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific to the parasite, in order to be able to perform a rational planning. This project intends to complement the studies that are already being developed in our labora…
A fact which leads to an increase in morbidity and mortality of malaria in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific in the parasite for to implement a rational planning. The present project proposes complement the studies that are being developed in our laboratory on the biosynt…
In spite of intense research, malaria remains the most devastating parasitic disease of mankind with ca. 200-300 annual million cases and 1.7-2.4 million deaths mostly in children below five years of age. In the particular case of Brazil, the Amazon region is responsible for almost all the clinical malaria attacks, which last year accounted for more than 600,000 cases with a socio-economi…
(Only some records are available in English at this moment)
Leishmaniasis is a parasitic disease caused by protozoa the genus Leishmania that represents an important problem public health. The treatment is considered a major challengedue to the limited therapeutic arsenal and serious adverse effects. The Leishmaniasis is related topoverty and the pharmaceutical industry has no interest due to the low financial return. According to the World Health…
Malaria is an infection disease caused by several species of Apicomplexa parasites of the genus Plasmodium. In 2017 Malaria affected 219 million people around the world and caused 435 thousand deaths, mostly by P. falciparum infections. Furthermore, to go up against the global emergence of drug resistance, new targets for drug development became necessary. Thereby, this work focuses on th…
The isoprenoid biosynthesis has been studied in Apicomplexa pathogens due to its particularity: these organisms present the typical route of photosynthetic or bacterial organisms, the methyl erythritol-phosphate pathway (MEP; DOXP). This fact encouraged numerous research groups to: (i) a fine characterization of the MEP enzymes and metabolites (i) study the role these enzymatic steps in p…
Malaria is a disease that has been a major public health problem in underdeveloped and emerging countries like Brazil, India, Indonesia, and much of the African continent that suffer from the growing number of cases. Caused by the species of parasites Plasmodium, the disease is serious and can lead to death. Therefore, in an attempt to control the effects of the disease, many drugs were d…
(Only some records are available in English at this moment)
One of the most promising targets for malaria drug design is the isoprenoid metabolism. Isoprenoid biosynthesis depends on the methylerythritol 4-phosphate (MEP) pathway, located in a modified plastid organelle called apicoplast. Isoprenoids produced by this pathway are used for isoprenylation of several metabolites and proteins. Former observations from our group demonstrated the plasmod…
One of the most promising targets for malaria drug design is the isoprenoid metabolism. Isoprenoid biosynthesis depends on the methylerythritol 4-phosphate (MEP) pathway, located in a modified plastid organelle called apicoplast. Isoprenoids produced by this pathway are used for isoprenylation of several metabolites and proteins. Former observations from our group demonstrated the plasmod…
Perillyl alcohol (POH) prevents ECM development, and that its potential mechanism of action can be by controlling the excessive immune response, downregulating the proinflammatory cytokines secretion in the spleen and brain. Also, we suggested that POH treatment may have a direct effect on the vascular endothelium activation , since we found that there was a significant improvement in th…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 15 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 32 / 18 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 57 / 34 | All research grants and scholarships |
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CV Lattes
ORCID