CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Argentina
bachelor's at Medicina from Universidad de Buenos Aires (1974) and doctorate at Microbiologia E Parasitologia from Universidad de Buenos Aires (1981). He is currently full professor at Universidade de São Paulo. Has experience in Parasitology, focusing on Human Parasite Protozoology, acting on the following subjects: malaria, plasmodium falciparum, drogas anti-malaricas, isoprenoides and trypanosoma cruzi. (Source: Lattes Curriculum)
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A fact that favors the increase in morbidity and mortality from malaria in the world is the resistance to chemotherapy drugs that the parasite presents. Therefore, it is necessary to identify new specific potential targets in the parasite, in order to carry out rational planning. The present project is intended to complement the studies that have already been developed in our laboratory f…
A fact which favors the increase in morbidity and mortality from Malaria in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific to the parasite, in order to be able to perform a rational planning. This project intends to complement the studies that are already being developed in our labora…
A fact which leads to an increase in morbidity and mortality of malaria in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific in the parasite for to implement a rational planning. The present project proposes complement the studies that are being developed in our laboratory on the biosynt…
In spite of intense research, malaria remains the most devastating parasitic disease of mankind with ca. 200-300 annual million cases and 1.7-2.4 million deaths mostly in children below five years of age. In the particular case of Brazil, the Amazon region is responsible for almost all the clinical malaria attacks, which last year accounted for more than 600,000 cases with a socio-economi…
(Only some records are available in English at this moment)
Malaria, caused by Plasmodium falciparum parasites, constitutes a substantial public health concern, particularly in developing nations. While existing medications hold the capacity to combat the disease, the emergence of Plasmodium resistance to these drugs has posed a formidable challenge, prompting the exploration for novel antimalarial agents. Drawing upon the discoveries of our resea…
Plasmodium falciparum is the etiologic agent of human falciform malaria, one of the most prevalent diseases in tropical and subtropical regions of the world. One of the largest problems for controlling the disease is the emergence of drug resistance, which leads to the need for discovering new antimalarial compounds and creating new effective pharmaceutical combinations. One of the most s…
Leishmaniasis is a parasitic disease caused by protozoa the genus Leishmania that represents an important problem public health. The treatment is considered a major challengedue to the limited therapeutic arsenal and serious adverse effects. The Leishmaniasis is related topoverty and the pharmaceutical industry has no interest due to the low financial return. According to the World Health…
Malaria is a disease that has been a major public health problem in underdeveloped and emerging countries like Brazil, India, Indonesia, and much of the African continent that suffer from the growing number of cases. Caused by the species of parasites Plasmodium, the disease is serious and can lead to death. Therefore, in an attempt to control the effects of the disease, many drugs were d…
(Only some records are available in English at this moment)
In animals, the mevalonate (MVA) pathway is the primary source of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). The MVA pathway is crucial for cholesterol biosynthesis and the prenylation of Ras and Rho oncoproteins, besides several other processes. Therefore, dysregulation of the MVA pathway is associated with hypercholesterolemia, oncogenesis, and other metabolic…
One of the most promising targets for malaria drug design is the isoprenoid metabolism. Isoprenoid biosynthesis depends on the methylerythritol 4-phosphate (MEP) pathway, located in a modified plastid organelle called apicoplast. Isoprenoids produced by this pathway are used for isoprenylation of several metabolites and proteins. Former observations from our group demonstrated the plasmod…
One of the most promising targets for malaria drug design is the isoprenoid metabolism. Isoprenoid biosynthesis depends on the methylerythritol 4-phosphate (MEP) pathway, located in a modified plastid organelle called apicoplast. Isoprenoids produced by this pathway are used for isoprenylation of several metabolites and proteins. Former observations from our group demonstrated the plasmod…
Perillyl alcohol (POH) prevents ECM development, and that its potential mechanism of action can be by controlling the excessive immune response, downregulating the proinflammatory cytokines secretion in the spleen and brain. Also, we suggested that POH treatment may have a direct effect on the vascular endothelium activation , since we found that there was a significant improvement in th…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 17 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 35 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 62 / 38 | All research grants and scholarships |
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