bachelor's at Licenciatura En Ciencias Biológicas from Universidad de La República (1994), master's at Biologia Molecular e Celular from Universidad de La República (1997) and doctorate at Bioquímica Instituto de Química from Universidade de São Paulo (2002). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: hpv, organotypic culture, raft, hpv, tnf, e7, diagnóstico molecular and culturas organotípicas. (Source: Lattes Curriculum)
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Some types of human papillomavirus (HPV) and the Epstein-Barr virus (EBV) are considered type 1 carcinogens by the International Agency for Research on Cancer (IARC). Together, these viruses are the etiologic factor in approximately 6% of new cancer cases worldwide. Infection with high-risk oncogenic HPV is the etiological factor of practically 100% of uterine cervix carcinomas and more t…
Infection with high oncogenic risk human papillomavirus (HPV) types is etiologically associated with almost all cases of cervical cancer, more than 50% of other anogenital carcinomas and a significant percentage of oropharynx tumors. High-risk HPV express two oncoproteins, E6 and E7 that act on specific cellular factors promoting continuous cell proliferation, resistance to apoptosis, res…
Some HPV types, known as high-risk HPVs, are etiologically associated with almost all the cases of cervical cancer and mora than 50% or other genital carcinomas. High-risk HPVs express two oncoproteins, E6 e E7, that act on specific cellular factors promoting sustained cell proliferation, resistance to apoptosis, resistance to cytokines, immune evasion and numeric and structural chromosom…
Some Human Papillomavirus (HPV) types, known as high-risk HPV types, are etiologically associated with almost all cervical tumors and over 50% of other anogenital cancers. Infection by these viruses has been associated with alterations in cellular proliferation pattern in tissues, increased nucleus/cytoplasm ratio in infected epithelial cells and multiple genomic alterations in infected c…
(Only some records are available in English at this moment)
Persistent infection with Human Papillomavirus is etiologically associated with a set of pathologies, especially cervical cancer. One of the scenarios that allows the establishment and maintenance of these diseases is alterations in the tumor microenvironment. Research from our group indicates that the expression of RECK, a membrane-localized protein that regulates the activity of metallo…
The Human Papilloma Virus (HPV) and the Epstein-Barr Virus (EBV) are two important viruses classified as carcinogenic. Thirteen types of HPV known as high-risk HPV are associated with virtually all cases of Cervical Cancer. In fact, HPV types 16 and 18 are responsible for 70% of cases of this tumor. The HPV proteins E6 and E7 are the main products that lead to cell transformation, both ar…
HPV is the etiologic agent of cervical cancer, which causes the death of over a quarter million women every year worldwide. HPV types classified as high-oncogenic risk are responsible for the great majority of the cases. In order to establish a productive infection HPV has to evade the protective mechanisms of the host cell, such as autophagy and the innate immune response. Three viral pr…
Human Papillomavirus (HPV)-induced carcinogenesis comprises alterations in Extracellular Matrix (ECM) components such as Matrix Metalloproteinases (MMP) and their regulators. REversion-inducing Cysteine-rich protein with Kazal motifs (RECK) inhibits the activation of specific MMP and its expression is frequently lost in human cancers. Different mRNA products of RECK gene may be generated …
Human papillomaviruses (HPV) that infect the cervix can be classified as low risk or high oncogenic risk. Infection with low-oncogenic risk HPV is associated with the development of benign papillomas and low-grade lesions with a low tendency for malignant progression, which are usually eliminated by the host immune system. However, high-risk HPVs have a high carcinogenic potential and are…
(Only some records are available in English at this moment)
Up regulation of metalloproteinases type 2 and 9 (MMP-2 and MMP-9) expression and activity are the most common extracellular matrix (ECM) related modifications in precursor cervical lesions and invasive carcinoma. We reported that this event correlated with the expression of MMP inhibitors, including REversion-inducing Cysteine-rich protein with Kazal motifs (RECK). Reduced RECK mRNA and …
| 1 / 1 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 8 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 19 / 16 | All research grants and scholarships |
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CV Lattes
ORCID