CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Institute of Biosciences of Botucatu (IBB), São Paulo State University (UNESP), where he works in the field of Biochemistry and coordinates the Laboratory of Bioassays and Cellular Dynamics (LaBIO). He holds a Bachelors degree in Biological Sciences from UNESP (2005) and a PhD in Biochemistry from the University of Campinas (UNICAMP, 2008), including a doctoral sandwich period at the Universitair Medisch Centrum Groningen (UMCG), the Netherlands. His research focuses on Biochemistry and Cell Biology, with emphasis on signal transduction mechanisms in mammalian cells, molecular regulation of cellular differentiation, and inter-tissue communication under physiological and pathological conditions.His research lines focus on bone biology and its systemic interfaces, tissue bioengineering, development of biomimetic materials, functional analysis of biomaterials, interactions between bone and metabolically active tissues, as well as nanotoxicology and cellular responses to biomaterials and physicochemical stimuli. His group seeks to understand bone as an endocrine and systemic regulatory organ, investigating the integration between tissue microenvironment, bone remodeling, and chronic diseases, with a translational focus on regenerative strategies and the development of advanced biomedical technologies.He coordinates the Laboratory of Bioassays and Cellular Dynamics (LaBIO), established with support from FAPESP and consolidated as a multi-user platform dedicated to the study of cellular and molecular processes in diverse biomedical contexts. LaBIO brings together undergraduate, MSc, PhD, and postdoctoral researchers, as well as national and international collaborators, contributing to the training of highly qualified human resources and to scientific production in international peer-reviewed journals. The laboratory also provides support to multiple research groups, strengthening scientific and technological integration at institutional and interinstitutional levels.He is the coordinator of INCT-BIOCRON the National Institute of Science and Technology in Bone Biology and Control of Chronic Diseases, headquartered at UNESP. The institute articulates a national and international research network dedicated to investigating the systemic functions of bone, its relationship with chronic diseases, and the development of innovative biomimetic and therapeutic approaches. INCT-BIOCRON integrates researchers from multiple Brazilian and international institutions, consolidating UNESP as a reference center in bone biology, regenerative medicine, and advanced biomedical technologies.He maintains scientific collaborations with institutions in the United States, the Netherlands, Portugal, the United Kingdom, Ireland, Italy, India, and Canada, participating in cooperative projects, training programs, and scientific exchange initiatives. He served as Vice-Director of the Institute of Biosciences of Botucatu (20212024), contributing to the academic and scientific management of the unit, and has been a CNPq Research Productivity Fellow since 2013. His trajectory is marked by academic leadership, consolidation of multi-user scientific infrastructure, and the proposition of innovative approaches at the interface of bone biology, tissue bioengineering, and advanced biomedical technologies. (Source: Lattes Curriculum)
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The INCT-BIOCRON will be an interdisciplinary center dedicated to the study of chronic non-communicable diseases (NCDs), including obesity, type 2 diabetes, osteoporosis, cancer, Alzheimer's disease, and fertility disorders. Its central focus is to elucidate the endocrine role of bone, particularly osteocalcin, and its connection to energy metabolism, insulin sensitivity, and glucose cont…
Activation of the PI3K signaling pathway plays a central role in osteoblast proliferation, migration, and differentiation and can be modulated by various lipid mediators, such as lysophosphatidic acid (LPA). Given the growing interest in developing functional nanocarriers that mimic physiological stimuli, this project proposes the formulation and characterization of inorganic calcium phos…
Despite appearing to be static, bone tissue is highly dynamic, with a recognized ability to reshape and regenerate throughout the life of vertebrates; the coupling between osteoblasts and osteoclasts controls this activity. In case of extensive, critically sized lesions, support material is needed to contribute to tissue repair/regeneration events, requiring the clinical use of biomateria…
With increasing concern about the life expectancy of the population, regenerative processes of bone tissue have been urgently considered by emerging countries. Currently, it is shown that the growth of blood vessels in the bone is associated with osteogenesis, and little has been explored in the elaboration of biotechnological processes on this matter. Another important point at this conj…
For bone purposes, surface modifications are a common trend in biomaterials research aiming to reduce the time necessary for osteointegration, culminating in faster recovery of patients. In this scenario, analysis of intracellular signaling pathways have emerged as an important and reliable strategy to predict biological responses from in vitro approaches. We have combined global analysis…
(Only some records are available in English at this moment)
Bone regeneration is a complex process that can be compromised under chronic inflammatory conditions, making it essential to develop innovative biomaterials to aid tissue recovery. This project proposes the synthesis and characterization of a bioactive hydrogel composed of sodium alginate (SA) and beeswax (BW), aiming to evaluate its biocompatibility, physicochemical properties, and poten…
This project aims to evaluate the potential of ellagic acid (EA), a phenolic lactone, in modulating blood coagulation as a biomimetic strategy for developing advanced materials for bone regeneration. Considering the critical role of blood coagulation in the initial stages of osseointegration, the ability of EA to activate Factor XII (Hageman factor) indicates its promising application for…
Bone tissue, beyond its structural role, functions as an endocrine organ influencing energy metabolism through hormones such as osteocalcin, produced by osteoblasts. Recent evidence indicates that the expression of the BGLAP gene, which encodes osteocalcin, is epigenetically regulated by mechanisms including DNA methylation, histone modifications, and microRNAs (miRNAs). These processes d…
(Only some records are available in English at this moment)
Despite appearing static, bone tissue is highly dynamic, with a recognized capacity for remodeling and regeneration throughout the lifespan of vertebrates, an activity controlled by the coupling between osteoblasts and osteoclasts. In cases of extensive and critical-sized lesions, the need for support material arises to contribute to tissue repair/regeneration events, requiring the clinic…
One must consider the central role that the skeleton plays in the human body, following the command that other tissues and organs regulate, which indicates that, in addition to its mechanical functions, bone is an endocrine tissue, which modulates cellular activities in different fabrics. The growing understanding that bone is a paracrine and endocrine organ serves to broaden our understa…
Organ-on-a-chip (OoC) technology consists of microfluidic devices for culturing cells that resemble tissues/organs on a physiological level. This technology has shown expectation for tissue engineering, biosensors, diagnosis and therapy, drug delivery and has gained special prominence in bioengineering and biomedical engineering research. Compared to animal models and 2D cell culture mode…
(Only some records are available in English at this moment)
The regeneration of critical bone defects and the recurrence of bone metastases (e.g., breast cancer) after surgery represent a significant clinical challenge, demanding combined anti-tumor and pro-regenerative therapeutic approaches. In this context, bone tissue engineering offers powerful biomimetic platforms for the in vitro study and optimization of new therapies. This project aims at…
Bone remodeling is a tightly regulated process that depends on coordinated interactions between vascular and skeletal systems. Recent findings have highlighted the role of extracellular vesicles (EVs) derived from human aortic smooth muscle cells (AoSMCs) as key modulators of osteoblast differentiation and osteocyte transition, suggesting a novel mechanism of intercellular communication l…
Repairing large or non-healing bone defects is challenging and often expensive. Biomimetic materials, such as collagen-nanohydroxyapatite (Coll-nHA) scaffolds, effectively promote bone repair and osteogenesis. To address larger critical-sized defects, advanced materials are necessary to enhance the interplay between angiogenesis and osteogenesis. Long non-coding RNAs, particularly lncMALA…
This project explores an innovative approach to developing 3D-shapeable biomaterials for bone tissue engineering using photocrosslinkable rotational molding. Given the essential role of bone tissue in providing structural support and protection, regeneration is often necessary regeneration after injury. Biomaterials offer promising scaffolding solutions to support and enhance this regener…
It is timely to consider that cardiovascular diseases make up one of the major causes of death worldwide. The central role of vascular tissue has gained attention in recent years, mainly associated with increasing of aging. Vascular calcification, previously considered a passive degenerative condition of aging, is characterized by an ectopic deposition of inorganic calcium phosphate cryst…
With the increase in life expectancy and growth of urban centers, bone regeneration has become an issue of interest, mainly because it has increased the number of elderly and young people with fractures. Although it is able to regenerate itself in small injuries, there is a necessity to improve therapies able to support the regeneration of large disorders, mainly when a scaffold is requir…
(Only some records are available in English at this moment)