Maria José Vieira Fonseca

• Abstract

  Maresin 1 (MaR1) is a lipid derived from docosahexaenoic acid that not only reduces inflammation as anti-inflammatories, but also activates endogenous pro-resolution mechanisms for the end of inflammation. The MaR1 also features a different class of macrophages, the resolving macrophage. This macrophage has characteristics such as maintaining microbicidal activity such as M1 macrophages w…

  Development of a nanostructured system for controlled release of lipid pro-resolution: analgesic effect on inflammation and neuropathy, anti-inflammatory effect on infection and tissue repair, AP.R

• Abstract

  Exposure to the ultraviolet radiation is the main risk factor for the development of skin cancer. Special attention should be given to long-term exposure because it is primarily responsible for premature aging and skin cancer. Safety and efficacy studies evaluate sunscreens under acute conditions of exposure to the ultraviolet radiation, which is not consistent with the actual conditions …

  Establishment of a Human Organotypic Skin Explant Culture as an alternative method to assess efficacy and safety of sunscreens: Employment of Zinc Oxide nanoparticles as a validation tool and comparison with the results obtained in the culture medium, AP.R

• Abstract

  In Brazil, skin cancer is the tumor with the highest incidence and accounts for 25% of all malignant tumors reported in the country. However, the use of sunscreens is increasing proportionally to the incidence of skin disorders associated with ultraviolet (UV) light. This fact may be related to instability filters and excipients of photoprotective formulations, as well as the interactions…

  Development, standardization and validation of in vitro methods for assessing the efficacy of the photoprotective formulation in UVA-I, UVA-II and UVB bands, AP.R

(Only some records are available in English at this moment)

• Abstract

  The skin presents several antioxidant defense mechanisms. However, some situations, such as longer exposition to ultraviolet radiation (UVR), are able to increase the concentration of reactive oxygen species (ROS). The generation of ROS might take to photoaging and diseases like cancer. Topic administration of antioxidants is an efficiently way to improve endogenous skin protective system…

  Evaluation in vivo and in vitro of the photochemoprevention potential of the Lychnophora salicifolia Mart. extract, BP.DR
• In vitro evaluation of the effect of sunscreens on the activity of antioxidants involved in skin defense system, BP.IC
• Comparison of photochemopreventive effect of apple extract and rutin in "in vitro" skin explants culture and "in vivo" skin hairless mice models, BP.DR

(Only some records are available in English at this moment)