Erick da Cruz Castelli

• Abstract

  The Leukocyte Receptors Complex (LRC), which comprehends approximately 1Mb of chromosome 19, is comprised by genes that mostly codify molecules of the Immunoglobulin superfamily (Ig). Among these genes, the Immunoglobulin-like Killer Receptors Family (KIR), expressed on Natural Killer (NK) cells and T cytotoxic lymphocytes, and the Leucocyte Immunoglobulin-like Receptors (LILRs), expresse…

  KIR2DL4, KIR3DL2, KIR3DL3, LILRB1 (ILT2) and LILRB2 (ILT4) variability and haplotypes in a Brazilian population sample from the São Paulo state, AP.R
• 67th Annual Meeting of the American Society of Human Genetics, AR.EXT

• Abstract

  The Major Histocompatibility Complex (MHC) is the most variable region of the human genome. The classical class I genes within the human MHC (HLA-A, HLA-B and HLA-C) are associated with antigen presentation to T CD8+ cells. These genes are quite variable, allowing the presentation of many different peptides. However, such degree of polymorphisms is challenging when tissue transplantation …

  Evaluation of MHC Class I genes variability, regulation and evolutive history, AP.R

• Abstract

  The MHC complex presents several genes involved in the innate and adaptive immune responses. The HLA-E gene encodes cell surface proteins that act in inflammatory processes and modulates Natural Killer (NK) and T-cell responses through activating (CD94/NKG2C) and inhibitory receptors (CD94/NKG2A). Although the HLA-E gene is quite conserved in protein diversity, recent studies demonstrate…

  HLA-E transcription profile and MHC polymorphisms influencing its expression profile and isoforms, BP.IC

• Abstract

  The HLA class II genes encode molecules that have a pivotal role in the process of antigenic presentation and therefore, they are important in several physiological and pathological conditions, such as infections, graft-host reactions, neoplasms, and autoimmune diseases. Variability is an important characteristic of HLA class II genes, which allows them to present thousands of different p…

  Genetic diversity of HLA class II genes in worldwide populations and detection of variants that influence the expression profile of these genes, BP.DR

• Abstract

  The Killer cell immunoglobulin-like receptors (KIR) complex encode many surface receptors that are expressed in Natural Killer (NK) cells. Their main ligands are the highly variable HLA class I molecules. KIR receptors modulate NK activity positively or negatively, depending on the receptor and the ligands. Here we will evaluate the KIR3DL2 3'UTR diversity in highly admixed Brazilian samp…

  KIR3DL2 3'UTR diversity in Brazilian samples and microRNA binding profile, BP.IC

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