Bachelor in Biological Sciences - Biomedicine at Universidade Estadual Paulista Júlio de Mesquita Filho, Master and PhD in Sciences (Pharmacology) at University of Sao Paulo. MBA in Management of Innovation in Heath at Butantan Institute. Actually, she associate researcher at Butantan Institute, acting on the following subjects: snake venoms, inflammation and pain. She is coordenating the scientific diffusion at Center of Excelence in Target Discovery. (Source: Lattes Curriculum)
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Paclitaxel is a chemotherapy drug widely used to eliminate breast and ovarian cancer. Despite being effective against cancer cells, this chemotherapy induces neuropathy in about 70% of the patients. So far, little is known about the mechanisms involved in paclitaxel-induced neuropathy and the treatment is often ineffective or non-existent. Mitochondria are critical organelles to supply th…
Adequate control of neuropathic pain is still a challenge and an unmet clinical need. In addition, adverse effects and rapid development of tolerance have been associated to some of the drugs currently used for the treatment of pain, evidencing the need for new analgesic substances. Aldehyde-dehydrogenase 2 (ALDH-2) is a mitochondrial enzyme responsible for the metabolism of toxic aldehyd…
Paclitaxel is a chemotherapeutic widely used to treat breast and ovarian cancer. Despite its efficacy against cancer cells, this drug triggers neuropathy in about 70% of the patients. So far, it is known that this drug induces microtubule stabilization and interrupts the axonal transport, leading to ATP impairment and increased oxidative stress. Studies demonstrate a causal correlation be…
Advanced Glycation End Products (AGEs) are formed from the irreversible binding of sugar molecules with proteins such as collagen. Studies show that the formation of AGEs is associated with the development of peripheral neuropathy and pain. Our group previously demonstrated that sensory neurons gain pro-nociceptive function when in the presence of AGEs. Despite this evidence, we do not ye…
Aldehyde dehydrogenase-2 (ALDH-2) is a mitochondrial enzyme responsible for eliminating toxic aldehydes from the peroxidation of unsaturated lipids present in the mitochondrial membrane. Initial studies carried out by our group, using a small activating molecule of ALDH-2, Alda-1, demonstrated that this molecule has a potent antinociceptive effect in an acute model of inflammatory hyperno…
Aldehyde dehydrogenese-2 (ALDH-2) is a mithocondrial enzyme which metabolizes reactive aldehydes. Aldehydes accumulation such as 4-hidroxinonenal (4-HNE) has been related to increased pain. 4-HNE is an aldehyde formed by the oxidation of unsatured lipids in the mitochondrial membrane. Recently, our group showed that activation of ALDH2, using a small molecule called Alda-1, displays antin…
Aldehyde-dehydrogenase 2 (ALDH-2) is a mitochondrial enzyme responsible for the metabolism of toxic aldehydes, including the removal of 4-hydroxynonenal (4-HNE), an aldehyde generated during mitochondrial lipid peroxidation. 4-HNE accumulation has been recently related to increased pain. Recent data from our group has been shown that activation of ALDH2, using a small molecule (Alda-1), d…
(Only some records are available in English at this moment)
Opioids are effective analgesics for treating moderate to severe pain, however, chronic opioid use results in the development of opioid tolerance. This tolerance to opioids causes the need over time for increased doses of opioids to achieve the same pain-relieving effect. Clinical evidence suggests that East Asians are more responsive to opioids and possibly resistant to opioid tolerance…
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 6 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 12 | All research grants and scholarships |
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CV Lattes
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