- Research Grants
Bachelor in Biological Sciences - Biomedicine at Universidade Estadual Paulista Júlio de Mesquita Filho, Master and PhD in Sciences (Pharmacology) at University of Sao Paulo. MBA in Management of Innovation in Heath at Butantan Institute. Actually, she associate researcher at Butantan Institute, acting on the following subjects: snake venoms, inflammation and pain. She is coordenating the scientific diffusion at Center of Excelence in Target Discovery. (Source: Lattes Curriculum)
Aldehyde dehydrogenese-2 (ALDH-2) is a mithocondrial enzyme which metabolizes reactive aldehydes. Aldehydes accumulation such as 4-hidroxinonenal (4-HNE) has been related to increased pain. 4-HNE is an aldehyde formed by the oxidation of unsatured lipids in the mitochondrial membrane. Recently, our group showed that activation of ALDH2, using a small molecule called Alda-1, displays ant...
Aldehyde-dehydrogenase 2 (ALDH-2) is a mitochondrial enzyme responsible for the metabolism of toxic aldehydes, including the removal of 4-hydroxynonenal (4-HNE), an aldehyde generated during mitochondrial lipid peroxidation. 4-HNE accumulation has been recently related to increased pain. Recent data from our group has been shown that activation of ALDH2, using a small molecule (Alda-1),...
(Only some records are available in English at this moment)
Opioids are effective analgesics for treating moderate to severe pain, however, chronic opioid use results in the development of opioid tolerance. This tolerance to opioids causes the need over time for increased doses of opioids to achieve the same pain-relieving effect. Clinical evidence suggests that East Asians are more responsive to opioids and possibly resistant to opioid toleran...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
ZAMBELLI, Vanessa Olzon. Avaliação da expressão e ativação de receptores opióides após injúria periférica em ratos.. 2011. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/00135-2)