CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Instituto Nacional de Farmacologia (INFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Maria Luiza Vilela Oliva holds a degree in Chemistry (both Licentiate and Bachelor) from Faculdades Oswaldo Cruz (1978), a Master's (1981), and a Ph.D. (1988) in Biological Sciences with an emphasis on Molecular Biology from the Federal University of São Paulo (UNIFESP). Currently, she is a Full Professor and Tenured Professor at UNIFESP, a CNPq Researcher Level 1A, and an ordinary member of the Brazilian Society of Biochemistry.Her research focuses on the structural and kinetic characterization of proteolytic enzyme inhibitors isolated from plants, investigating their interaction with enzymes to understand the mechanisms involved in proteolysis regulation. These studies have potential applications in the development of inhibitors that modulate biological processes such as blood coagulation, blood pressure regulation, inflammation, and tumor cell proliferation. Currently, she is also investigating fragments derived from these proteins in models of breast cancer, glioblastoma, and melanoma, focusing on their antitumor, anti-inflammatory, and antithrombotic effects.The main topics of her scientific production include platelet aggregation, protease inhibitors, cancer (with an emphasis on breast cancer), coagulation, protein structure, inflammation, the kallikrein-kinin system, Kunitz-type proteins, medicinal plants, bioactive peptides, thrombosis, and COVID-19. (Source: Lattes Curriculum)
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razilian flora is considered an important source of natural products that may be beneficial to all mankind. Studies of these resources require a concerted effort of the Brazilian scientific institutions. Our research group has been conducting comparative studies of protease inhibitors from leguminose seeds, determining the primary, secondary and tertiary structures, as well as modeling of…
Cardiovascular disease is a diverse family of diseases encompassing heart attacks and strokes which collectively account for the single major cause of morbidity worldwide with an urgent need for new medicines. As an example, Ischemic stroke is a devastating disease that represents the primary reason for sustained disability and the second leading cause of death worldwide. The holy grail o…
Brazilian flora is considered an important source of natural products that may be beneficial to all mankind. Studies of these resources require a concerted effort of the Brazilian scientific institutions. Our research group has been conducting comparative studies of protease inhibitors from leguminous seeds, determining the primary, secondary and tertiary structures, as well as modeling o…
(Only some records are available in English at this moment)
Proteases are abundant in cells and play an important role in intracellular proteolysis. In breast cancer, the imbalance of these proteolytic enzymes stimulates cell growth and metastasis, acting on the degradation and modification of the extracellular matrix, influencing the regulation and processing of membrane receptors related to tumor growth. Thus, intervention by natural protease in…
The term glioblastoma refers to astrocytoma with the highest level of malignancy (grade IV), and even though its incidence is low when compared to other malignant tumors, it is one of the most lethal human tumors, with only a 12-15 months period of survival. These tumors can be classified according to the existence of a pre-lesion, such as secondary glioblastomas, which develop from lower…
Breast Cancer is characterized by uncontrolled and atypical proliferation of breast cells and can occur in both men and women, although it is less frequent in males. It is cancer that most affects women around the world, especially before the age of 40 in pre-menopause. There are three groups into which breast cancer can be classified: positive for estrogen (ER) or progesterone (PR) recep…
Studies with the bifunctional protein CrataBL have shown that this protein prolongs the partially active thromboplastin test time (aPTT) by influencing the intrinsic coagulation pathway, and in addition it inhibits the effect of heparin on the same pathway suggesting that the interaction of CrataBL with Heparin neutralizes its anticoagulant effects. Contrary to the action of heparin, Crat…
(Only some records are available in English at this moment)
Cancer is a disease that still leads to death in many countries, with the incidence > 90% of the mortality attributable to metastases (Valastyan & Weinberg, 2011). In Brazil, the estimates for 2014 point to the occurrence of 576,000 new cases of cancer. Breast cancer, the most frequent type of this disease in women, has very high mortality rate (INCA, 2014). The 60 cancer cell lines (NCI-…
| 1 / 1 | Ongoing grants |
| 14 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 22 / 13 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 40 / 26 | All research grants and scholarships |
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