bachelor's at Medicina from Universidade de São Paulo de Ribeirão Preto (1974), master's at Clínica Medica from Universidade de São Paulo de Ribeirão Preto (1979) and doctorate at Clínica Médica from Universidade de São Paulo de Ribeirão Preto (1981). He is currently full professor at Universidade Estadual de Campinas. Has experience in Medicine, focusing on Hematology, acting on the following subjects: anemia falciforme, talassemia, biologia molecular, lmc and nitric oxide. (Source: Lattes Curriculum)
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The proposed Thematic Project "Pathophysiological Mechanisms and Treatment of Red Blood Cell Abnormalities" will be developed by the Red Blood Cell Research Group at the Hematology Center, the Department of Clinical Pathology and the Center for Molecular Biology and Genetic Engineering (CBMEG), UNICAMP, in collaboration with various Brazilian and international researchers. The project aim…
The proposed Thematic Project "Pathophysiological Mechanisms and Treatment of Red Blood Cell Abnormalities" will be developed by the Red Blood Cell Research Group at the Hematology Center, the Department of Clinical Pathology and the Center for Molecular Biology and Genetic Engineering (CBMEG), UNICAMP, in collaboration with various Brazilian and international researchers. The project aim…
Sickle cell disease (SCD) is a devastating genetic condition, prevalent in African-Brazilian and African-British communities. While most patients are affected by severe organ complications, some patients have mild disease, which offers hope for the development of new treatment strategies. The KCL lab has been at the forefront of studies identifying genes and gene variants that cause part …
Red blood cell disorders: Pathophysiology and new therapeutic approaches, this Project is developed by the Research Group on Red blood cells formed by researchers of the Blood Center, Department of clinical pathology, Faculty of medical sciences and the Molecular Biology and Genetic Engineering Center (CBMEG) at UNICAMP in collaboration with several Brazilian and international researchers…
ImagestreamX Mark II (Amnis) proposal for the acquisition of the ImagestreamX Mark II equipment which combines flow cytometry techniques with optical fluorescence microscopy. Whole blood samples or isolated cells are labeled with immunofluorescent molecules and the ImageStreamX equipment, used in combination with the IDEAS software, will allow the determination of the mean fluorescence in…
(Only some records are available in English at this moment)
Erythropoiesis is the physiological process responsible for the production of erythrocytes that occurs mainly in the bone marrow. The formation and maturation of erythrocytes involve a series of complex molecular events, including the participation of multiple transcription factors, cytokines, and elements of the bone marrow microenvironment. Disorders in erythropoiesis can lead to inadeq…
In disorders characterized by chronic hemolytic anemia, such as sickle cell disease (SCD), recurrent processes of intravascular hemolysis result in the release of hemoglobin (Hb) and heme. In conditions of chronic intravascular hemolysis, iron regulatory mechanisms are depleted, resulting in iron overload in the plasma and increased tissue iron deposition. This excess of iron in tissues l…
Sickle-cell disease is a serious, chronic disorder and undoubtedly represents a public health problem in Brazil. Patients need to be accompanied for lifelong in specialized centers with a multidisciplinary team to control symptoms and prevent sickle cell crisis. The only treatment option for sickle cell anemia so far is related hematopoietic stem cell transplantation (BMT), indicated in s…
(Only some records are available in English at this moment)
In healthy adults, fetal hemoglobin (HbF) levels are residual, but in some circumstances, there may be a variation with higher levels (0.8 to 5%), and this condition is called hereditary heterocellular persistence of HbF. In sickle cell disease (SCD), the increased expression of HbF during adulthood can improve the clinical course of the disease and prolong the life expectancy of these pa…
Sickle-cell disease is a serious, chronic disorder and undoubtedly represents a public health problem in Brazil. Patients need to be accompanied for lifelong in specialized centers with a multidisciplinary team to control symptoms and prevent sickle cell crisis. The only treatment option for sickle cell anemia so far is related hematopoietic stem cell transplantation (BMT), indicated in s…
(Only some records are available in English at this moment)
Priapism is defined as a penile erection that persists beyond or is unrelated to sexual interest or stimulation, and is one of the complications associated with sickle cell disease (SCD). This condition constitutes a urological emergency requiring prompt diagnosis and treatment, since it is associated with erectile tissue damage and erectile dysfunction, a known complication. Current ther…
Hereditary persistence of fetal hemoglobin (HPFH) is a condition characterized by elevated synthesis of g-globin in adult definitive erythroid cells, which normally have only very low levels of fetal hemoglobin (HbF), due to a failure in the hemoglobin switch from HbF to adult hemoglobin (HbA). Fetal hemoglobin is a major genetic modifier of the phenotypic heterogeneity in patients with t…
| 2 / 2 | Ongoing research grants |
| 24 / 9 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 44 / 19 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 78 / 38 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID