Abstract
Bone biomineralization is an exquisite process mediated and controlled by cells that culminate in the building of a highly hierarchical hybrid matrix. The building block of this matrix is the mineralized collagen fibrils, where hydroxyapatite (HAp) crystals are infiltrated in the fibril. The origin of these HAp crystals is regarded to the action of Matrix Vesicles (MV). These lipid vesicl…