Débora C Damasceno holds a Bachelor of Science in Biological Sciences with a major in Biomedical Sciences at São Paulo State University - Unesp (1993), Master in Biological Sciences at Unesp (1996), Ph.D.(2000) and postgraduate (2008) with degrees from the Post-graduation Course in Gynecology, Obstetrics and Mastology of Botucatu Medical School/Unesp. Currently is a researcher in the Gynecology and Obstetrics Department of Botucatu Medical School-Unesp, awarded with a CNPq Research Productivity Scholarship. She presents expertise in diabetes and pregnancy using laboratóry animals. She is member of the CNPq Group of Clinical and Experimental Research in Diabetes and Pregnancy, and leads the Oxidative Stress and Birth Defect Group. She is a faculty mentor for the Post-graduate Course in Tocogynecology of Botucatu Medical School. Most frequent keywords in published articles are: rat, pregnancy, streptozotocin, diabetes, oxidative stress, exercise, free radicals, fetal programming, and congenital malformation. She has collaboration with international institutions such as the Universidad de San Pablo_Spain; Havana/Cuba; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán_Ciudad de Mexico, Mexico, and Universidad de Valparaíso, Chile. She has conducted scientific studies with financial support of FAPESP and CNPq, and teachs undergraduate, graduate (Master?s and Ph.D.), and supervises postgraduate students with scholarships granted by FAPESP, CNPq and CAPES. (Source: Lattes Curriculum)
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Diabetes is a syndrome characterized by a functional change in the beta-pancreatic cell in insulin synthesis/secretion or due to an inadequate insulin action in peripheral tissues, leading to increased blood glucose concentration (hyperglycemia). The literature describes the pathophysiological mechanisms, such as oxidative stress, are involved in the repercussions of hyperglycemia in vari…
Regarding that diabetic pregnant women present congenital malformations rates, perinatal morbimortality five times larger than pregnant no diabetics and that, the preimplantation embryos of diabetic rats present high apoptosis index as the glycemic level increases, our hypothesis is that the immaturity in the antioxidant system in preimplantation embryo contributes to the embryopathies an…
(Only some records are available in English at this moment)
In addition to the physiological changes that occur during pregnancy, several diseases can affect the pregnant woman, causing numerous damages to her and her fetus. There are also several complications in the treatment of diseases during this period. Then, in the attempt to increase the efficiency in the treatment of diseases, the use of magnetic nanoparticles have attracted great attenti…
Changes occur during intrauterine life that are capable of influencing both the embryonic and fetal development and the adult life of the offspring, increasing the risk for the diabetes onset. Among these diseases, Diabetes mellitus may be cited, which promotes an unfavorable intrauterine environment. The understanding of existing mechanisms regarding the tolerance of the adaptive respons…
Diabetes is a syndrome characterized by a abnormal function of the beta-pancreatic cell in synthesizing / secreting insulin or by the fact that insulin does not adequately exert its action in the peripheral tissues, leading to an increase of the circulating glucose concentration (hyperglycemia). It is estimated that 1.6 million deaths are caused by diabetes. Among the various stages of li…
(Only some records are available in English at this moment)
The main focus of the Loeken laboratory is to understand how maternal diabetes causes congenital malformations. Using a mouse model of diabetic pregnancy, Loeken and colleagues have shown that increased glucose metabolism by embryos inhibits expression of Pax3, a gene required for neural tube closure, and that inhibition of Pax3 expression leads to neural tube defects (NTDs), one of the m…
Maternal diabetes effects on congenital malformations are due to hyperglycemia-induced oxidative stress, and that oxidative stress inhibits expression of genes that are essential for early organogenesis in the embryo. In particular, research team from Joslin Diabetes Center_Harvard Medical School has shown that oxidative stress inhibits Pax3 expression, which encodes a protein that is req…
There is evidence that hyperglycemia induces increased production of reactive oxygen species (ROS). The main source intracellular of ROS is the mitochondria and alterations associated to the mitochondrial phenotype in the diabetes have been widely described. To promote the mitochondrial biogenesis, studies show that peroxisome proliferator-activated receptor coactivator 1 alfa (PGC-1alfa)…
| 11 / 6 | Completed research grants |
| 19 / 12 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 33 / 21 | All research grants and scholarships |
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