CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Débora C Damasceno holds a Bachelor of Science in Biological Sciences with a major in Biomedical Sciences at São Paulo State University - Unesp (1993), Master in Biological Sciences at Unesp (1996), Ph.D.(2000) and postgraduate (2008) with degrees from the Post-graduation Course in Gynecology, Obstetrics and Mastology of Botucatu Medical School/Unesp. Currently is a researcher in the Gynecology and Obstetrics Department of Botucatu Medical School-Unesp, awarded with a CNPq Research Productivity Scholarship. She presents expertise in diabetes and pregnancy using laboratóry animals. She is member of the CNPq Group of Clinical and Experimental Research in Diabetes and Pregnancy, and leads the Oxidative Stress and Birth Defect Group. She is a faculty mentor for the Post-graduate Course in Tocogynecology of Botucatu Medical School. Most frequent keywords in published articles are: rat, pregnancy, streptozotocin, diabetes, oxidative stress, exercise, free radicals, fetal programming, and congenital malformation. She has collaboration with international institutions such as the Universidad de San Pablo_Spain; Havana/Cuba; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán_Ciudad de Mexico, Mexico, and Universidad de Valparaíso, Chile. She has conducted scientific studies with financial support of FAPESP and CNPq, and teachs undergraduate, graduate (Master?s and Ph.D.), and supervises postgraduate students with scholarships granted by FAPESP, CNPq and CAPES. (Source: Lattes Curriculum)
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Diabetes mellitus (DM) is a growing epidemic worldwide due to a multifactorial combination of genetic and environmental factors. Type 2 Diabetes mellitus (DM2), with greater prevalence, increases the risk of multiple diseases and its etiology combines insulin resistance and/or deficiency in insulin secretion, together with pancreatic ²-cell failure. Research based on genome sequencing has…
Diabetes mellitus (DM) is one of the most serious health problems in the world, which represents a significant threat to public health. Intrauterine exposure to diabetes can affect fetal development leading to long-term effects on the health of the offspring. The development of metabolic, structural, and functional changes in various organs, including the endocrine pancreas (pancreatic is…
Diabetes is a syndrome characterized by a functional change in the beta-pancreatic cell in insulin synthesis/secretion or due to an inadequate insulin action in peripheral tissues, leading to increased blood glucose concentration (hyperglycemia). The literature describes the pathophysiological mechanisms, such as oxidative stress, are involved in the repercussions of hyperglycemia in vari…
Regarding that diabetic pregnant women present congenital malformations rates, perinatal morbimortality five times larger than pregnant no diabetics and that, the preimplantation embryos of diabetic rats present high apoptosis index as the glycemic level increases, our hypothesis is that the immaturity in the antioxidant system in preimplantation embryo contributes to the embryopathies an…
(Only some records are available in English at this moment)
Diabetes mellitus (DM) is a growing epidemic worldwide due to a multifactorial combination of genetic andenvironmental factors. Type 2 Diabetes mellitus (DM2), with greater prevalence, increases the risk ofmultiple diseases and its etiology combines insulin resistance and/or deficiency in insulin secretion,together with pancreatic ²-cell failure. Research based on genome sequencing has fo…
Maternal and environmental factors act at the beginning of life and can have repercussions on the vulnerability to diseases and on the health process in the individual's adult life or in animals. Due to the inconclusive findings in the literature regarding the treatment of diabetes with vitamin D, the purpose of this study is to verify whether treatment with insulin, associated or not wit…
Diabetes mellitus is a syndrome characterized by hyperglycemia resulting from a lack of insulin due to autoimmune destruction of pancreatic beta(²) cells or insulin resistance in peripheral tissues, leading to the exhaustion of these cells responsible for the synthesis and secretion of insulin. Uncontrolled maternal diabetes is widely used as a model to cause fetal growth restriction in l…
Adherence to a healthy diet during pregnancy is essential for preventing gestational disorders that can compromise various organs and tissues, such as the liver. During pregnancy, the liver grows slightly and has a greater work capacity. Considering experimental models in animals, it has already been demonstrated that rats that consumed a high-fat diet from weaning until adulthood (120 da…
Maternal diabetes causes a lower number of embryonic implantations, a higher rate of embryonic death and fetal malformations due to the imbalance in the redox state induced by hyperglycemia. Vitamin D supplementation has been shown to reduce oxidative stress, plays a significant role in stimulating endocrine-pancreatic cells, and increases insulin sensitivity. In addition, there is eviden…
(Only some records are available in English at this moment)
The main focus of the Loeken laboratory is to understand how maternal diabetes causes congenital malformations. Using a mouse model of diabetic pregnancy, Loeken and colleagues have shown that increased glucose metabolism by embryos inhibits expression of Pax3, a gene required for neural tube closure, and that inhibition of Pax3 expression leads to neural tube defects (NTDs), one of the m…
Maternal diabetes effects on congenital malformations are due to hyperglycemia-induced oxidative stress, and that oxidative stress inhibits expression of genes that are essential for early organogenesis in the embryo. In particular, research team from Joslin Diabetes Center_Harvard Medical School has shown that oxidative stress inhibits Pax3 expression, which encodes a protein that is req…
There is evidence that hyperglycemia induces increased production of reactive oxygen species (ROS). The main source intracellular of ROS is the mitochondria and alterations associated to the mitochondrial phenotype in the diabetes have been widely described. To promote the mitochondrial biogenesis, studies show that peroxisome proliferator-activated receptor coactivator 1 alfa (PGC-1alfa)…
| 2 / 2 | Ongoing grants |
| 11 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 22 / 15 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 40 / 28 | All research grants and scholarships |
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