Francisco Carlos Groppo

• Abstract

  Researches on local anesthetic (LA) seek clinical treatment as close as possible to the "no pain" treatment. Although used for the temporary blockage of the nervous conductivity, LAs also modulate cellular pathways related to inflammatory response, wound healing, apoptosis and cellular necrosis. While the search for the ideal molecule remains a challenge, new anesthetic formulations from …

  Effects of Lidocaine/Prilocaine mixture in poly-L-lysine/hyaluronic acid films on gingival fibroblasts and in a tail model in mice: in vitro and in vivo study, AP.R
• 94th General Session & Exhibition of the IADR, the 3rd Meeting of the IADR Asia Pacific Region and the 35th Annual Meeting of the IADR Korean Division, AR.EXT

• Abstract

  The most effective pain control has motivated the research for new local anesthetic formulations. The association with lipossomal or ciclodextrin carriers has been proposed in order to prolong the anesthetic effect and reducing its toxicity. New anesthetic formulations produced a low systemic toxicity and longer duration of anesthesia. Adverse effects were also observed. One of the side e…

  Modulatory effects of local anesthetics associated with carriers on the production of inflammatory mediators and cell viability in oral epithelial cells and human gingival fibroblasts, AP.R

(Only some records are available in English at this moment)

• Abstract

  Temporomandibular disorders (TMD) encompass a set of craniofacial changes, which may involve TMJ, chewing muscles and associated structures. Unlike other cyclooxygenase inhibitors, acetylsalicylic acid (ASA) increases the formation of lipoxins derived from arachidonic acid, which help in the resolution of inflammation. Resolvins derived from polyunsaturated fatty acids, especially eicosap…

  The effect of association of aspirin and omega 3 in a CFA-induced inflammatory process in the temporomandibular joint (TMD) of rats: a pilot study, BP.IC

• Abstract

  The most effective control of pain has motivated the search for new local anesthetic formulations. The association with carriers has been proposed in order to prolong the anesthetic effect and reducing its toxicity. New anesthetic formulations produced a low systemic toxicity and longer duration of anesthesia. Adverse effects were also observed as the appearance of inflammatory painless w…

  Effects of local anesthetic associated with carriers in the modulation of inflammatory mediators, cell viability and apoptosis induction, BP.DD
• The modulatory effects of lidocaine associated with drug-carriers over cytokines production of human oral epithelial cells., BP.IC

(Only some records are available in English at this moment)

• Abstract

  Periodontal diseases affect a large percentage of the adult population. The chronic inflammatory nature of this disease creates a cascade of inflammatory mediators that are both locally and systemically destructive, contributing to heart disease, stroke, rheumatoid arthritis, low birth-weight babies and possibly gastro-intestinal diseases. The inflammatory mediators also contribute to cha…

  Long lasting treatment for gingivitis, BE.PQ