CV Lattes
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ORCID
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
master's at Neurology from Universidade Federal de São Paulo (1996) and doctorate at Neurology from Universidade Federal de São Paulo (2001). He is currently full professor at Universidade Federal de São Paulo. Has experience in Medicine, acting on the following subjects: epilepsia, epilepsy, pilocarpine, pilocarpina and seizure. (Source: Lattes Curriculum)
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Parkinson's disease (PD) is one of the most common neurodegenerative diseases related to aging. In addition to motor signals, people with PD also present non-motor changes, such as autonomic and cognitive alterations. Cardiorespiratory dysfunctions in PD are common manifestations associated with increased morbidity and mortality. The risk of PD is twice as high in men than in women. Howev…
Parkinson's disease (PD) is one of the most common age-related neurodegenerative disorders. Moreover, epidemiological studies have shown that people with PD are more likely to die prematurely than those without PD, and an important PD-related category of death is sudden unexpected death in Parkinson's disease (SUDPAR). Additionally, the cause of SUDPAR is still unknown; however, the most …
Patients with epilepsy have 2 to 3 times more chance to die prematurely than general population and the sudden unexpected death in epilepsy (SUDEP) is responsible for 2-18% of these cases. However still unknown the causes of the SUDEP, but cardiac system seen to have important participation in this scenario. In this sense, alterations in heart rate and in heart rate variability can be see…
Human and animal studies have demonstrate that exercise targets many aspects of brain function and has broad effects on overall brain health. Exercise activates molecular and cellular cascades that support and maintain brain plasticity. It induces expression of genes associated with plasticity, and in addition promotes neurogenesis and increased brain vascularization and metabolism. Such …
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in humans. Evidence supports the fact that neuronal injury observed in epilepsy may be the result of an overproduction of free radicals (oxidative stress) and related to excitotoxicity event. Mitochondria is responsible for ATP synthesis but also is involved in Ca2+ uptake and release, transient mitochondrial permeability an…
The nervous system is responsible for the organization and coordination of the body, simple functions to elaborate requiring precise connections between different types of nerve cells. Inputs and outputs of the neural network depends on the synaptic connectivity of the network and the individual properties of each synapse and are associated with the action of adhesion molecules. The devel…
The possible contribution of the thalamus to the onset and spreading of epileptic discharges has been extensively discussed and thalamic atrophy has been found in patients with temporal lobe epilepsy (TLE), with the anterior and posterior thalamic nuclei being mainly affected. In this sense, it is necessary to elucidate whether structural changes in the lateral-posterior (LP) nucleus occu…
(Only some records are available in English at this moment)
This research is designed to explore the biological basis of seizure-induced neurogenesis in the mature central nervous system (CNS) and the role of neurogenesis in the pathophysiology of epilepsy. Previous work has demonstrated that various forms of experimental seizures paradigms, lead to a marked increase in the mitotic activity of precursor cell located at the subgranular zone of the …
| 1 / 1 | Ongoing research grants |
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| 7 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 9 | All research grants and scholarships |
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