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Sonir Roberto Rauber Antonini

CV Lattes ResearcherID

Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Full Professor and Head of the Department of Pediatrics of Ribeirao Preto Medical School of the University of Sao Paulo (Brasil - FMRP-USP). Supervisor of Master, PhD and Postodoctoral students. Holds a Research Productivity Scholarship at CNPq since 2007. Doctor at UFSM-RS (1991), Medical Residency at Pediatrics and Pediatric Endocrinology at HC-FMRP-USP (1995); Master's degree (1997): "Interaction between circadian rhythm of cortisol and sleep in preterm infants" and Doctorate (2001): "Molecular basis of adrenocorticotropic tumors" at FMRP-USP. Postdoctoral fellow at the University of Montreal, Canada (2001-2003): "Molecular basis of macronodular adrenal hyperplasia". Teaching in 2013 (Adrenocortical Tumorigenesis). He is Deputy Director of the Brazilian Society of Endocrinology and Metabology (SBEM) -Regional São Paulo and Coordinator of the Continuing Education Commission of the Latin American Society of Pediatric Endocrinology (SLEP). Organizes and will be the President of the 2019 SLEP Congress. He received the Gutemberg Rocha Award as a distinguished professor at FMRP-USP. He was a Professor honored by 13 FMRP Graduate Groups, being Paraninfo in 2010 and Patronus in 2018. He received the following Research Awards: CAPES Theses (n = 1), COPEM (n = 3), SLEP (n = 4), Presidential Poster of the Endocrine Society (n = 2) and Editora Abril's 2014 Health Award. At HC-FMRP-USP he is one of the coordinators of the Center for Genomic Medicine Ad hoc Consultant at FAPESPe CNPq and the University of Padua, Italy. He is Sectional Co-editor (Endocrinology and Pediatrics) of the Brazilian Journal of Biomedical Research and Biology. Reviewer of journals including The Journal of Clinical Endocrinology and Metabolism, European Journal of Endocrinology, Clinical Endocrinology, Hypertension and Brazilian Archives of Endocrinology, among others. He has an intense dedication to undergraduate teaching, coordinating pediatric undergraduate teaching and is an active member of the FMRP-USP Undergraduate Commission. Acts extra-walls with CARL Diabetes League Tutor. He works in Assistance and Extension in the HC-FMRP-USP Pediatric Endocrinology Department, where he is the head of the discipline. At FMRP-USP Graduate, he coordinates the Teaching Improvement Program (PAE) and is vice-coordinator of the Graduate Program in Child and Adolescent Health. Coordinates the HC-FMRP-USP Laboratory of Molecular Endocrinology and guides undergraduate, master's, doctoral and postdoctoral students. His research focus (ORCID: 0000-0003-4778-8803) mainly involves the study of the molecular basis of endocrine diseases, especially adrenal, such as adrenocortitic tumors (CAT). He is Principal Investigartor (PI) of FAPESP Thematic Project, whose focus is to evaluate cellular signaling pathways (Wnt / beta-catenin, SHH, YAP1-Hippo and VDR) through Next Generation Sequencing, in vitro and in vivo studies with murine xenographic models. Additionally, it investigates molecular bases of adrenal insufficiency and gonadal dysgenesis using tools such as CRISP-Cas9. He has worked in research lines involving mineralocorticoid resistance, congenital hypopituitarism, precocious puberty and adiponectin, IGF1 and MR gene polymorphisms and their relationship with growth and metabolism. FAPESP thematic projects. Maintains regular research collaboration in Brazil with the Boldrini Children's Center and Endocrinology researchers at HC-FMUSP. On the international scene, she has maintained lasting collaboration with Maria-Christina Zennaro of INSERM, Paris-France and collaborations with Constatine Stratakis (NIH) and Ursula B. Kaiser (Harvard Medical School) in the USA. He is currently coordinating a national multicenter research project supported by the National Cancer Institute of the United States National Institutes of Health (NCI-NIH) in partnership with Steven Chanock. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

LEAL, LETICIA F.; BUENO, ANA CAROLINA; GOMES, DEBORA C.; ABDUCH, RAFAEL; DE CASTRO, MARGARET; ANTONINI, SONIR R.. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. ONCOTARGET, v. 6, n. 40, p. 43016-43032, . Web of Science Citations: 24. (11/10512-3, 11/13807-4)

MARTINS, CLARISSA S.; FERNANDES-ROSA, FABIO L.; ESPINEIRA, ANIETTE R.; DE SOUZA, ROBERTO MOLINA; DE CASTRO, MARGARET; BARBIERI, MARCO A.; BETTIOL, HELOISA; JORGE, ALEXANDER L.; ANTONINI, SONIR R.. The growth hormone receptor exon 3 polymorphism is not associated with height or metabolic traits in healthy young adults. GROWTH HORMONE & IGF RESEARCH, v. 24, n. 4, p. 123-129, . Web of Science Citations: 7.

BUENO, ANA CAROLINA; SUN, KAI; MARTINS, CLARISSA SILVA; ELIAS JUNIOR, JORGE; MIRANDA, WALLACE; TAO, CAROLINE; FOSS-FREITAS, MARIA CRISTINA; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; DE CASTRO, MARGARET; et al. A Novel ADIPOQ Mutation (p.M40K) Impairs Assembly of High-Molecular-Weight Adiponectin and Is Associated With Early-Onset Obesity and Metabolic Syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 99, n. 4, p. E683-E693, . Web of Science Citations: 11. (09/17095-9)

PAULO, SABRINA SOARES; FERNANDES-ROSA, FABIO L.; TURATTI, WENDY; COELI-LACCHINI, FERNANDA BORCHERS; MARTINELLI, JR., CARLOS E.; NAKIRI, GUILHERME S.; MOREIRA, AYRTON C.; SANTOS, ANTONIO C.; DE CASTRO, MARGARET; ANTONINI, SONIR R.. Sonic Hedgehog mutations are not a common cause of congenital hypopituitarism in the absence of complex midline cerebral defects. Clinical Endocrinology, v. 82, n. 4, p. 562-569, . Web of Science Citations: 9. (10/11510-1)

FERNANDES-ROSA, FABIO L.; HUBERT, EDWIGE-LUDIWYNE; FAGART, JEROME; TCHITCHEK, NICOLAS; GOMES, DEBORA; JOUANNO, ELODIE; BENECKE, ARNDT; RAFESTIN-OBLIN, MARIE-EDITH; JEUNEMAITRE, XAVIER; ANTONINI, SONIR R.; et al. Mineralocorticoid Receptor Mutations Differentially Affect Individual Gene Expression Profiles in Pseudohypoaldosteronism Type 1. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 96, n. 3, p. E519-E527, . Web of Science Citations: 15.

FERNANDES-ROSA, F. L.; BUENO, A. C.; DE SOUZA, R. MOLINA; DE CASTRO, M.; DOS SANTOS, J. ERNESTO; FOSS, M. C.; ZENNARO, M-C.; BETTIOL, H.; BARBIERI, M. A.; ANTONINI, S. R.. Mineralocorticoid receptor p.l180V polymorphism: Association with body mass index and LDL-cholesterol levels. Journal of Endocrinological Investigation, v. 33, n. 7, p. 472-477, . Web of Science Citations: 10.

ANTONINI‚ SRR; LATRONICO‚ AC; ELIAS‚ LLK; CUKIERT‚ A.; MACHADO‚ HR; LIBERMAN‚ B.; MENDONCA‚ BB; MOREIRA‚ AC; CASTRO‚ M.. Glucocorticoid receptor gene polymorphisms in ACTH-secreting pituitary tumours. Clinical Endocrinology, v. 57, n. 5, p. 657-662, .

ESPINEIRA, ANIETTE RENOM; FERNANDES-ROSA, FABIO LUIZ; BUENO, ANA CAROLINA; DE SOUZA, ROBERTO MOLINA; MOREIRA, AYRTON CUSTODIO; DE CASTRO, MARGARET; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; ANTONINI, SONIR RAUBER. Postnatal growth and cardiometabolic profile in young adults born large for gestational age. CLINICAL ENDOCRINOLOGY, v. 75, n. 3, p. 335-341, . Web of Science Citations: 25.

STECCHIN, MONICA F.; BRAID, ZILDA; MORE, CANDY B.; ARAGON, DAVI C.; CASTRO, MARGARET; MOREIRA, AYRTON C.; ANTONINI, SONIR R.. Gonadotropin-dependent pubertal disorders are common in patients with virilizing adrenocortical tumors in childhood. ENDOCRINE CONNECTIONS, v. 8, n. 5, p. 579-589, . Web of Science Citations: 2. (14/03989-6, 15/19663-5)

LEAL, LETICIA FERRO; SZAREK, EVA; BERTHON, ANNABEL; NESTEROVA, MARIA; FAUCZ, FABIO R.; LONDON, EDRA; MERCIER, CHRISTOPHER; ABU-ASAB, MONES; STAROST, MATTHEW F.; DYE, LOUIS; et al. Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation. Molecular and Cellular Endocrinology, v. 522, . Web of Science Citations: 0. (13/05337-3)

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