Marcia Aparecida Silva Graminha in research grants and scholarships supported by FAPESP.
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Leishmaniasis is a pathogenic disease found throughout the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance to them makes providing new therapeutic alternatives urgen…
Leishmaniasis is a pathogenic disease found throughout the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance to them makes providing new therapeutic alternatives urgen…
The World Health Organization (WHO) estimates that more than one billion people suffer from neglected tropical diseases. Leishmaniasis is a widespread disease, affecting 12 million people around the world with about 1-2 million estimated new cases occurring every year. For more than 60 years, pentavalent antimonials, Sb (V) compounds, have been the first-line chemotherapy against leishman…
(Only some records are available in English at this moment)
Leishmaniasis is a highly prevalent neglected disease caused by more than 20 species of protozoan parasites of the genus Leishmania (order: Kinetoplastida; family: Trypanosomatidae) transmitted by the bite of sandflies. The therapeutic treatment of leishmaniasis has several drawbacks, from the limited diversity of drugs currently available to high toxicity, which makes the search for new …
Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania and endanger 350 million people worldwide. There are few available drugs for the treatment of this parasitic disease that present several drawbacks such as high toxicity and low efficacy, turning urgent the search for new drugs. The transmission occurs by the inoculation of metacyclic promastigotes into the h…
Leishmaniases are considered Neglected Diseases, resulting from infection by protozoa of the genus Leishmania, being endemic in large areas of the tropics, subtropics and Mediterranean basin, affecting more than 98 countries. According to the World Health Organization, around one billion people live in areas endemic for leishmaniasis and are at risk of acquiring the infection. The organiz…
The leishmaniasis correspond to a set of clinical manifestations caused by different species of Leishmania, transmitted to the mammal host through the bite of infected female phlebotomines during the blood repast. This parasitic disease is labeled as neglected and therefore presents few therapeutic options for its control, which are toxic and present very difficult routes of administratio…
(Only some records are available in English at this moment)
Leishmaniasis is a neglected disease that remains a major health problem around the word. A limited number of effective antileishmanial drugs are available for chemotherapy, and many of them are associated with high toxicity, difficult administration route and low efficacy. Therefore, there is an urgent need to develop a novel safe and effective antileishmanial drug. Previously, we report…
Leishmaniasis affects millions of people worldwide and is considered one of Neglected Tropical Diseases (NTDs) by affecting mainly the populations in developing countries. There are few drugs available for the treatment of leishmaniasis, which are toxic and often ineffective due to the emergence of resistant strains, thus the search for new compounds with leishmanicidal activity is justif…
The leishmaniasis are a group of diseases caused by the genus Leishmania. These affect 350 million people in the world in its two main forms, the cutaneous leishmaniasis and visceral leishmaniasis. After the complete sequencing of the genome of Leishmania major and the breakthrough in sequencing other species (Leishmania braziliensis, L. mexicana and L. infantum), much has been advanced r…
(Only some records are available in English at this moment)
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 13 / 10 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 23 / 20 | All research grants and scholarships |
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