Fernando Segato is an Associate Professor at the School of Engineering of Lorena, University of São Paulo (EEL-USP). Graduated in pharmacy and biochemistry (2002), Ph.D. in genetics and molecular biology of microorganisms from the Faculty of Medicine of Ribeirão Preto - University of São Paulo (2008) and post-doctorate in biotechnology and development of expression systems from Oklahoma State University, United States, was a researcher in the area of biotechnology at the VTT Technical Research Center of Finland. Has experience in Genetics, with an emphasis on Molecular and Microorganism Genetics, acting on the following topics: filamentous fungi, heterologous expression of proteins of biotechnological and industrial interest, RNA interference, drug resistance, prospecting and characterization of enzymes of interest biotechnology, structural biology, degradation of lignocellulosic materials, proteome and transcriptome of thermophilic microorganisms. In 2014, he was responsible for the Implementation of the research and development line in synthetic and molecular biology in the Department of Biotechnology and since then he has been coordinating the SyMB Lab (https://sites.usp.br/symb/), having participated in some editions iGEM (Genetically Engineering Machines Competition) in Boston, with medals awarded in 2016 and 2018. (Source: Lattes Curriculum)
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This project would combine the talents of the researchers, Dr. David Cannella of the Université libre de Bruxelles (CPBL-BioCat), Dr. Fernando Segato, Dr. Gabriela Berto and Dr. Adriane Milagres (SyMBLab) of the University of São Paulo (USP), to develop an enzymatic cocktail to tailor hemicellulose from sugarcane bagasse to produce biomolecules that can act as biostimulant for plant autod…
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic enzy…
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic enzy…
(Only some records are available in English at this moment)
Recently, enzymes with oxidative mechanisms acting straight on crystalline cellulose have been described as LPMOs. Since that, these enzymes have been added to the commercial cocktails boosting their performance, making them the focus of several studies, such as: mode of action, interaction with substrate and electron donors including the enzyme CDH. Through the analysis of amino acid seq…
Brazil is the largest producer of sugarcane in the world and generates a large amount of bagasse and crop residues that could be used in the production of second generation ethanol from cellulose, the main source of glucose in this waste. However, like other lignocellulosic substrates, these materials are extremely recalcitrant, which difficult the access to the cellulose in an economical…
Production of fuels and chemicals from renewable lignocellulosic biomass is difficult due to its recalcitrance to deconstruction. This recalcitrance is mostly due to presence of lignin in plant cell walls. Lignin is disrupted and/or removed from plant cell walls through expensive physicochemical pretreatments that use harsh chemicals, high temperatures and high pressures. Lignin in lignoc…
(Only some records are available in English at this moment)
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic enzy…
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic en…
Filamentous fungi are recombinant protein expression platforms of growing biotechnological interest. Their potent secretory pathways and highly competent cellular machinery show great potential for the development of expression systems capable of yielding several different recombinant proteins of both industrial and commercial interest. One of the main approaches in the obtention of recom…
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic en…
TIMPs are human proteins that inhibits MMPs maintaining the tissue homeostasis. The TIMP1 protein has a N- and C-terminus domains that act independently. Its configuration promotes a contradictory functionality to the TIMP1, since the N-terminus domain inhibits the action of MMPs, while the C-terminus domain induce the MMPs production. Due to this trait it is possible to explore the th…
(Only some records are available in English at this moment)
Since the discovery of oxidative depolymerization of crystalline cellulose by enzymes known as lytic polysaccharide monooxygenases (LPMOs), these enzymes have been integrated into commercial enzyme cocktails, significantly improving overall hydrolytic performance. LPMOs require a polysaccharide substrate and an enzymatic (such as cellobiose dehydrogenase; CDH) or non-enzymatic electron do…
In recent years, oxidative proteins known as lytic polysaccharide monooxygenases (LPMOs) have been discovered, which act directly on crystalline cellulose. The incorporation of LPMOs into commercial enzyme cocktails has substantially enhanced their performance. Moreover, LPMOs have been the subject of numerous studies focusing on their mode of action, substrate interactions, and electron …
Lytic polysaccharide monooxygenases (LPMOs) are gaining importance in plant biomass valorization due to their ability to accelerate biomass saccharification to platform sugars and to create functional groups in cellulose fibers. As LPMOs are a relatively recent discovery, many of their characteristics remain unknown, including the role of enigmatic disordered C-terminal regions (dCTRs) th…
The use of high-solid loadings in biorefineries is a requirement to consolidate and improve the production of 2G bioethanol. In this process an increase in residual lignin and lignin-related compounds (LRC) contents have a negative effect on the enzymatic saccharification of plant biomass. In preliminary analyses from the current PhD project, the negative effect of LRC on the activity of…
| 4 / 4 | Ongoing grants |
| 6 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 12 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 28 / 26 | All research grants and scholarships |
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