Fernando Segato is an Associate Professor at the School of Engineering of Lorena, University of São Paulo (EEL-USP). Graduated in pharmacy and biochemistry (2002), Ph.D. in genetics and molecular biology of microorganisms from the Faculty of Medicine of Ribeirão Preto - University of São Paulo (2008) and post-doctorate in biotechnology and development of expression systems from Oklahoma State University, United States, was a researcher in the area of biotechnology at the VTT Technical Research Center of Finland. Has experience in Genetics, with an emphasis on Molecular and Microorganism Genetics, acting on the following topics: filamentous fungi, heterologous expression of proteins of biotechnological and industrial interest, RNA interference, drug resistance, prospecting and characterization of enzymes of interest biotechnology, structural biology, degradation of lignocellulosic materials, proteome and transcriptome of thermophilic microorganisms. In 2014, he was responsible for the Implementation of the research and development line in synthetic and molecular biology in the Department of Biotechnology and since then he has been coordinating the SyMB Lab (https://sites.usp.br/symb/), having participated in some editions iGEM (Genetically Engineering Machines Competition) in Boston, with medals awarded in 2016 and 2018. (Source: Lattes Curriculum)
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Recently, enzymes with oxidative mechanisms acting straight on crystalline cellulose have been described as LPMOs. Since that, these enzymes have been added to the commercial cocktails boosting their performance, making them the focus of several studies, such as: mode of action, interaction with substrate and electron donors including the enzyme CDH. Through the analysis of amino acid seq…
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic enzy…
Lignocellulose is an abundant source of polysaccharides that can be used as a renewable raw material for the production of biofuels and other compounds of interest. The conversion of lignocellulose into its subunits is a slow and costly process, therefore, more study is needed to make this process feasible. Until recently, the available enzymatic cocktails were composed of hydrolytic enzy…
Brazil is the largest producer of sugarcane in the world and generates a large amount of bagasse and crop residues that could be used in the production of second generation ethanol from cellulose, the main source of glucose in this waste. However, like other lignocellulosic substrates, these materials are extremely recalcitrant, which difficult the access to the cellulose in an economical…
Production of fuels and chemicals from renewable lignocellulosic biomass is difficult due to its recalcitrance to deconstruction. This recalcitrance is mostly due to presence of lignin in plant cell walls. Lignin is disrupted and/or removed from plant cell walls through expensive physicochemical pretreatments that use harsh chemicals, high temperatures and high pressures. Lignin in lignoc…
Lignocellulosic biomass is an abundant source of polysaccharides that can be used as a renewable raw material to produce biofuels and other compounds. The conversion of these polysaccharides into fermentable sugars by enzymatic pathway still is a slow and expensive process, which a fast and efficient process still remains to be discovered. Until recently, the available commercial preparat…
(Only some records are available in English at this moment)
TIMPs are human proteins that inhibits MMPs maintaining the tissue homeostasis. The TIMP1 protein has a N- and C-terminus domains that act independently. Its configuration promotes a contradictory functionality to the TIMP1, since the N-terminus domain inhibits the action of MMPs, while the C-terminus domain induce the MMPs production. Due to this trait it is possible to explore the th…
LPMOs (Lytic Polysaccharide Monooxygenases) are metalloenzymes that depend on the presence of a copper atom in their active site, which needs to be reduced by an electron donor to initiate the catalysis process. Among the redox partners for LPMOs are several low molecular weight molecules (ascorbic acid, for example), photoactivated pigments, lignin or enzymes such as cellobiose dehydroge…
The use of biomass from the sugar and alcohol sector, such as sugarcane bagasse and straw for the production of biofuels and chemical compounds still represents a challenge for the development of biorefinery in Brazil. In view of its large-scale production sugarcane residues have a great energy potential and still are inefficiently exploited. The enzymatic hydrolysis step has been used to…
(Only some records are available in English at this moment)
The recent discovery of the enzymes called LPMOs or PMOs (Lytic Polysaccharide Monooxygenase or Polysaccharide Monooxygenase) opened new perspectives on the enzymatic mechanisms involved in the deconstruction of lignocellulosic biomass. Similarly, these prospects have significantly impacted the increase in the number of patents filed and related scientific publications. This impact has be…
The increase in global demand for fuels combined with the problems related to the emission of greenhouse gases into the atmosphere has put fuels in the spotlight, amongst them the second-generation ethanol, produced by alcoholic fermentation of carbohydrates obtained from the hydrolysis of vegetal biomass. Among the several ways that lignocellulosic biomass can be hydrolyzed to fermentabl…
The plant cell wall polysaccharides are an abundant source as renewable raw material and can be used to produce biofuels and other compounds. The enzymatically conversion of these polysaccharides into fermentable sugars still is a slow and high cost process; therefore, a fast and efficient process must be developed. Nowadays, the commercial cocktails had only enzymes whose hydrolysis mech…
(Only some records are available in English at this moment)
The use of high-solid loadings in biorefineries is a requirement to consolidate and improve the production of 2G bioethanol. In this process an increase in residual lignin and lignin-related compounds (LRC) contents have a negative effect on the enzymatic saccharification of plant biomass. In preliminary analyses from the current PhD project, the negative effect of LRC on the activity of…
| 3 / 3 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 5 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
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